Persistent Airway Hyperresponsiveness Following Recovery from Infection with Pneumonia Virus of Mice

Autor: Ajinkya R. Limkar, Caroline M. Percopo, Jamie L. Redes, Kirk M. Druey, Helene F. Rosenberg

Publikováno v: Viruses, Vol 13, Iss 5, p 728 (2021)

Respiratory virus infections can have long-term effects on lung function that persist even after the acute responses have resolved. Numerous studies have linked severe early childhood infection with respiratory syncytial virus (RSV) to the developmen

Externí odkaz: https://doaj.org/article/e2affcd9dc804446a01372afc6dd90e4

Aspergillus fumigatus–Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma

Autor: Eunice C. Chan, Chandra C. Ghosh, Sumati Ram-Mohan, Helene F. Rosenberg, Albert C. Sek, Kirk M. Druey, Ramaswamy Krishnan, Ming Zhao, Trisha Basu, Jamie L Redes

Publikováno v: ImmunoHorizons. 3:368-377

The hallmark features of allergic asthma are type 2 (eosinophilic) inflammation and airways hyperresponsiveness (AHR). Although these features often comanifest in mouse lungs in vivo, we demonstrate in this study that the serine protease Alp1 from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe3da59709a06e8d9d92065a40f2af5e
https://doi.org/10.4049/immunohorizons.1900046

Alternaria alternata Accelerates Loss of Alveolar Macrophages and Promotes Lethal Influenza A Infection

Autor: Laura S. Kraemer, Jamie L Redes, Kirk M. Druey, Caroline M. Percopo, Helene F. Rosenberg, Mahnaz Minai, Ian N. Moore, Eric Mai, Michelle Ma

Publikováno v: Viruses
Viruses, Vol 12, Iss 946, p 946 (2020)
Volume 12
Issue 9

Chronic inhalation of fungi and fungal components has been linked to the development of respiratory disorders, although their role with respect to the pathogenesis of acute respiratory virus infection remains unclear. Here, we evaluate inflammatory p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6d53445af7a5aa0253be91854901f5
http://europepmc.org/articles/PMC7552021

Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis

Autor: Neil C. Henderson, Joshua Sciurba, Kevin M. Vannella, Nikhil Jiwrajka, Erik P. Karmele, Kevin M. Hart, Sandra White, Jamie L Redes, Thomas A. Wynn, Richard L. Gieseck

Publikováno v: Sciurba, J C, Gieseck, R L, Jiwrajka, N, White, S D, Karmele, E P, Redes, J, Vannella, K M, Henderson, N C, Wynn, T A & Hart, K M 2018, ' Fibroblast-specific integrin alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis ', The Journal of Pathology . https://doi.org/10.1002/path.5215

Fibroproliferative diseases affect a significant proportion of the world's population. Despite this, core mechanisms driving organ fibrosis of diverse etiologies remain ill defined. Recent studies suggest that integrin-alpha V serves as a master driv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fb10829f9d9099aa528881451e6db4
https://pubmed.ncbi.nlm.nih.gov/30536905