Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jamie L. Harden"'
Publikováno v:
F1000Research, Vol 4 (2015)
It is well known that infiltration of pathogenic T-cells plays an important role in psoriasis pathogenesis. However, the antigen specificity of these activated T-cells is relatively unknown. Previous studies using T-cell receptor polymerase chain rea
Externí odkaz:
https://doaj.org/article/b3866681780c481aa2d9857cc961b9b8
Publikováno v:
Experimental Dermatology
Atopic dermatitis (AD) is a chronic, systemic, inflammatory disease that affects the skin and is characterized by persistent itch and marked redness. AD is associated with an increased risk of skin infections and a reduced quality of life. Most AD tr
Autor:
Jamie L Harden, Steven M Lewis, Katherine C Pierson, Mayte Suárez-Fariñas, Tim Lentini, Francesca S Ortenzio, Lisa C Zaba, Raphaela Goldbach-Mansky, Anne M Bowcock, Michelle A Lowes
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111255 (2014)
Mutations in the caspase recruitment domain, family member 14 (CARD14) gene have recently been described in psoriasis patients, and explain the psoriasis susceptibility locus 2 (PSORS2). CARD14 is a scaffolding protein that regulates NF-κB activatio
Externí odkaz:
https://doaj.org/article/d6cdeb15b9694502ba56d2fcab0f63f8
Autor:
Hans Hofland, Rui Li, Jin Xu, Anne Lynn S. Chang, Jamie L. Harden, Yi Hsien Shih, Divya Rajendran
Publikováno v:
The Journal of investigative dermatology. 141(4)
Papulopustular rosacea (PPR) is a chronic inflammatory skin disease with limited treatment options. Although multiple pathways have been described to be upregulated in PPR, a mechanistic understanding of the key drivers and interaction between pathwa
Autor:
Mayte Suárez-Fariñas, Michelle A. Lowes, Leanne M. Johnson-Huang, Jamie L. Harden, Steven M. Lewis, Samantha R. Lish, James G. Krueger, Daniel S. Gareau, Tim Lentini
Publikováno v:
Journal of Allergy and Clinical Immunology. 137:1830-1840
Background Many human diseases arise from or have pathogenic contributions from a dysregulated immune response. One pathway with immunomodulatory ability is the tryptophan metabolism pathway, which promotes immune suppression through the enzyme indol
Publikováno v:
Journal of Autoimmunity. 64:66-73
Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology involving genetic risk factors and environmental triggers. Here we describe the many known genetic predispositions of psoriasis with respect to immune genes and
Autor:
Rui Li, Jamie L. Harden, Jin Xu, D. Rajendran, Hans Hofland, Anne Lynn S. Chang, Yi Hsien Shih
Publikováno v:
Journal of Investigative Dermatology. 140:S114
Publikováno v:
Journal of Investigative Dermatology. 139:B25
Autor:
Michelle A. Lowes, Narat John Eungdamrong, Jamie L. Harden, Nicholas Gulati, Judilyn Fuentes-Duculan, Luke A. Hyder, Juana Gonzalez, Katherine C. Pierson, Leanne M. Johnson-Huang, Lisa C. Zaba, Tim Lentini, Mayte Suárez-Fariñas
Publikováno v:
The Journal of investigative dermatology
Our group recently described a population of antigen-presenting cells that appear to be critical in psoriasis pathogenesis, termed inflammatory myeloid dendritic cells (CD11c(+)/blood dendritic cell (DC) antigen 1(-)). Triggering receptor expressed o
Autor:
Nejat K. Egilmez, Jamie L. Harden
Publikováno v:
Immunological Investigations. 41:738-764
This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of