Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jamie L. Bingaman"'
Autor:
John P. Dowling, Pavel A. Nikitin, Fang Shen, Halley Shukla, James P. Finn, Nirja Patel, Cezary Swider, Jamie L. Bingaman-Steele, Chris Nicolescu, Eden L Sikorski, Evan J. Greenawalt, Michael J. Morin, Matthew K. Robinson, Karen Lundgren, Benjamin C. Harman
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTImmune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients. Targeting suppressive mechanisms acting on innate immune ce
Externí odkaz:
https://doaj.org/article/687ffc074dce4fcdb4a25e4af9665e76
Autor:
Jillian M. DiMuzio, Baron C. Heimbach, Raymond J. Howanski, John P. Dowling, Nirja B. Patel, Noeleya Henriquez, Chris Nicolescu, Mitchell Nath, Antonio Polley, Jamie L. Bingaman, Todd Smith, Benjamin C. Harman, Matthew K. Robinson, Michael J. Morin, Pavel A. Nikitin
Publikováno v:
Vaccine: X, Vol 8, Iss , Pp 100098- (2021)
Patients who recover from SARS-CoV-2 infections produce antibodies and antigen-specific T cells against multiple viral proteins. Here, an unbiased interrogation of the anti-viral memory B cell repertoire of convalescent patients has been performed by
Externí odkaz:
https://doaj.org/article/3838a23d47594e7298ad698becdb3b0c
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The concentration of divalent cations is well-known to influence molecular processes such as enzymatic activity and RNA folding. Here the authors attempt to reproduce physiological conditions for RNA folding in vitro and establish an important contri
Externí odkaz:
https://doaj.org/article/b5ced1074e554fa39a75d8b11e9e1a20
Autor:
Pavel A. Nikitin, Jillian M. DiMuzio, John P. Dowling, Nirja B. Patel, Jamie L. Bingaman-Steele, Baron C. Heimbach, Noeleya Henriquez, Chris Nicolescu, Antonio Polley, Eden L. Sikorski, Raymond J. Howanski, Mitchell Nath, Halley Shukla, Suzanne M. Scheaffer, James P. Finn, Li-Fang Liang, Todd Smith, Nadia Storm, Lindsay G. A. McKay, Rebecca I. Johnson, Lauren E. Malsick, Anna N. Honko, Anthony Griffiths, Michael S. Diamond, Purnanand Sarma, Dennis H. Geising, Michael J. Morin, Matthew K. Robinson
Publikováno v:
Science Immunology. 7
Monoclonal antibodies are an efficacious therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, rapid viral mutagenesis led to escape from most of these therapies, outlining the need for an antibody cocktail with a bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba9c0fe6a471aff9ca68ce2d284df07
https://doi.org/10.1126/sciimmunol.abl9943
https://doi.org/10.1126/sciimmunol.abl9943
Autor:
Pavel A. Nikitin, Jillian M. DiMuzio, John P. Dowling, Nirja B. Patel, Jamie L. Bingaman-Steele, Baron C. Heimbach, Noeleya Henriquez, Chris Nicolescu, Antonio Polley, Eden L. Sikorski, Raymond J. Howanski, Mitchell Nath, Halley Shukla, Suzanne M. Scheaffer, James P. Finn, Li-Fang Liang, Todd Smith, Nadia Storm, Lindsay G. A. McKay, Rebecca I. Johnson, Lauren E. Malsick, Anna N. Honko, Anthony Griffiths, Michael S. Diamond, Purnanand Sarma, Dennis H. Geising, Michael J. Morin, Matthew K. Robinson
Using an unbiased interrogation of the anti-viral memory B cell repertoire of convalescent COVID-19 patients, we identified three human antibodies that when combined demonstrated both robust viral suppressive properties against all tested SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca46853486ce71107671127e851ce01
https://doi.org/10.1101/2021.10.18.464900
https://doi.org/10.1101/2021.10.18.464900
Autor:
Daniel D. Seith, Aileen Charlotte Button, Philip C. Bevilacqua, Andrew J. Veenis, Jamie L. Bingaman
Publikováno v:
ACS Catal
A number of small, self-cleaving ribozyme classes have been identified including the hammerhead, hairpin, hepatitis delta virus (HDV), Varkud satellite (VS), glmS, twister, hatchet, pistol, and twister sister ribozymes. Within the active sites of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef57e63fe4474f3624aa0343342b321
https://doi.org/10.1021/acscatal.7b02976
https://doi.org/10.1021/acscatal.7b02976
Autor:
Mitchell Nath, Chris Nicolescu, Todd M. Smith, Noeleya Henriquez, Antonio Polley, Nirja B. Patel, Jillian M. DiMuzio, Benjamin C. Harman, John P. Dowling, Morin Michael John, Robinson Matthew K, Pavel A. Nikitin, Raymond J. Howanski, Baron C. Heimbach, Jamie L. Bingaman
Publikováno v:
Vaccine: X
Vaccine: X, Vol 8, Iss, Pp 100098-(2021)
Vaccine: X, Vol 8, Iss, Pp 100098-(2021)
Patients who recover from SARS-CoV-2 infections produce antibodies and antigen-specific T cells against multiple viral proteins. Here, an unbiased interrogation of the anti-viral memory B cell repertoire of convalescent patients has been performed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5afdcb7b86ea9a825bfa7767d47ca9e
https://doi.org/10.1016/j.jvacx.2021.100098
https://doi.org/10.1016/j.jvacx.2021.100098
Publikováno v:
Biochemistry. 56:4313-4317
RNA enzymes, or ribozymes, catalyze internal phosphodiester bond cleavage using diverse catalytic strategies. These include the four classic strategies: in-line nucleophilic attack, deprotonation of the 2′-OH nucleophile, protonation of the 5′-O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2790149b4788c997ec91c2b91799dbe
https://doi.org/10.1021/acs.biochem.7b00662
https://doi.org/10.1021/acs.biochem.7b00662
Autor:
Neela H. Yennawar, David R. Stevens, Sharon Hammes-Schiffer, Philip C. Bevilacqua, Sixue Zhang, Jamie L. Bingaman
Publikováno v:
Nature Chemical Biology. 13:439-445
RNA enzymes (ribozymes) have remarkably diverse biological roles despite having limited chemical diversity. Protein enzymes enhance their reactivity through recruitment of cofactors; likewise, the naturally occurring glmS ribozyme uses the glucosamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d563cbcbfe1b3e8d85ea91c294a82914
https://doi.org/10.1038/nchembio.2300
https://doi.org/10.1038/nchembio.2300
Autor:
Philip C. Bevilacqua, Sixue Zhang, Jamie L. Bingaman, Sharon Hammes-Schiffer, David R. Stevens, Puja Goyal
Publikováno v:
The Journal of Physical Chemistry Letters
Ribozymes employ diverse catalytic strategies in their self-cleavage mechanisms, including the use of divalent metal ions. This work explores the effects of Mg2+ ions in the active site of the glmS ribozyme–GlcN6P cofactor complex using computation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bd39a8c98fbb746549920fb0416d10
https://doi.org/10.1021/acs.jpclett.6b01854
https://doi.org/10.1021/acs.jpclett.6b01854