Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jamie L. Betker"'
Autor:
Thomas J. Anchordoquy, Jamie L. Betker
Publikováno v:
J Pharm Sci
Nanoparticle-mediated drug delivery has long utilized PEGylation as a mechanism for reducing uptake by the reticuloendothelial system and extending circulation lifetimes. However, studies over the past 2 decades have established that immune responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d5460fd8b0183c83280f356c5cf947
https://doi.org/10.1016/j.xphs.2020.01.019
https://doi.org/10.1016/j.xphs.2020.01.019
Autor:
Jamie L. Betker, Thomas J. Anchordoquy
Publikováno v:
J Pharm Sci
It is becoming increasingly clear that the intravenous administration of nanoparticles elicits an immune response that compromises delivery efficiency and can be life threatening. This study investigated both the systemic and tissue-level cytokine re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ba863d7ab08c78e81db4c2baaf17f4
https://pubmed.ncbi.nlm.nih.gov/34929156
https://pubmed.ncbi.nlm.nih.gov/34929156
Publikováno v:
Therapeutic Delivery. 10:11-20
Aim: Conventional conjugation reactions often involve the use of activated PEG as a linker, but concerns about PEG-mediated reduction in intracellular delivery and enhanced immunogenicity have generated interest in developing methods that eliminate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39150371f50ebe03a9d14588f58ac05
https://doi.org/10.4155/tde-2018-0057
https://doi.org/10.4155/tde-2018-0057
Autor:
Karen M. Helm, Thomas J. Anchordoquy, Maria A. Nagel, Kristina L. Terrell, Dallas Jones, Christine R. Childs, Jamie L. Betker
Publikováno v:
Journal of Controlled Release. 286:85-93
Decades of research into improving drug delivery to tumors has documented uptake of particulate delivery systems by resident macrophages in the lung, liver, and spleen, and correlated short circulation times with reduced tumor accumulation. An implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a21593227eb974bf8d33cfcd0ddc2a
https://doi.org/10.1016/j.jconrel.2018.07.031
https://doi.org/10.1016/j.jconrel.2018.07.031
Autor:
Thomas J. Anchordoquy, Jamie L. Betker
Publikováno v:
Drug Delivery and Translational Research. 7:162-167
The relevance of using nude mouse models for evaluating drug delivery to human tumors has recently been questioned by numerous researchers. While the immune response is known to play a critical role in cancer, this study assesses the effect of using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5739146cb11b5e48bbf7912bd9ff967
https://doi.org/10.1007/s13346-016-0327-6
https://doi.org/10.1007/s13346-016-0327-6
Autor:
Marc A. Ilies, Marc A Ilies, Uttam Satyal, Vishnu D. Sharma, Christina M. Bailey, Ramanathan Nagarajan, Terri A. Camesano, Jamie L. Betker, Long Xu, Ye Zhang, Thomas J. Anchordoquy, Edithe Selwa, Bogdan I. Iorga, Shota Fujii, Mina Sakuragi, Kazuo Sakurai, Sean F. Gilmore, Wei He, Amy Rasley, Nicholas O. Fischer, Yang Chu, Tianbo Liu, D. Pan, G. Cui, C. T. N. Pham, M. H. Tomasson, K. N. Weilbaecher, G. M. Lanza, Vishnu Dutt Sharma, Jennifer A. Shif, Filiz Karagöz, Robert Dorresteijn, Klaus Müllen, Markus Klapper, Robert F. Pagels, Robert K. Prud’homme, Chester E. Markwalter, Weili Ma, Won H. Suh
Publikováno v:
ACS Symposium Series ISBN: 9780841232747
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df4dc0a091f784dc49f5310811792aeb
https://doi.org/10.1021/bk-2017-1271.ch003
https://doi.org/10.1021/bk-2017-1271.ch003
Autor:
Jamie L. Betker, Thomas J. Anchordoquy
Publikováno v:
Molecular Pharmaceutics
Cationic reagents are commonly used to facilitate DNA delivery, and transfection experiments are typically initiated in cell culture where the optimal charge ratio is determined. While transfection rates are often enhanced at higher +/– charge rati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b609e4ebd55bf5084438d37583d43ce
https://doi.org/10.1021/mp500604r
https://doi.org/10.1021/mp500604r
Autor:
Theodore W. Randolph, Thomas J. Anchordoquy, Nicole M. Payton, Jamie L. Betker, Michael F. Wempe
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 85:306-313
As liquid liposomal formulations are prone to chemical degradation and aggregation, these formulations often require freeze drying (e.g. lyophilization) to achieve sufficient shelf-life. However, liposomal formulations may undergo oxidation during ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1741e79444d495b2a170adefb86fc6
https://doi.org/10.1016/j.ejpb.2013.03.028
https://doi.org/10.1016/j.ejpb.2013.03.028
Publikováno v:
Therapeutic Delivery. 4:453-462
Background: The formation of cholesterol domains in lipoplexes has been associated with enhanced serum stability and transfection rates both in cell culture and in vivo. Results: This study utilizes the ability of saturated phosphatidylcholines to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e77934c5c0c208a41a79d89d56a674
https://doi.org/10.4155/tde.13.16
https://doi.org/10.4155/tde.13.16