Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jamie L. Arnst"'
Autor:
Christina M. Knippler, Jamie L. Arnst, Isaac E. Robinson, Veronika Matsuk, Tala O. Khatib, R. Donald Harvey, Mala Shanmugam, Janna K. Mouw, Haian Fu, Thota Ganesh, Adam I. Marcus
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109591- (2024)
Summary: Targeting cancer metabolism to limit cellular energy and metabolite production is an attractive therapeutic approach. Here, we developed analogs of the bisbiguanide, alexidine, to target lung cancer cell metabolism and assess a structure-act
Externí odkaz:
https://doaj.org/article/23b5922f597f4f7084cf0f89ddff9f8a
Autor:
Joseph L. Roberts, Mingcan Yu, Manjula Viggeswarapu, Jamie L. Arnst, Roberto Pacifici, George R. Beck Jr
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
The intake of dietary phosphate far exceeds recommended levels; however, the long-term health consequences remain relatively unknown. Here, the chronic physiological response to sustained elevated and reduced dietary phosphate consumption was investi
Externí odkaz:
https://doaj.org/article/ad4a4086c828464eac336155a4505759
Autor:
Amarnath Natarajan, Michael A. Hollingsworth, Yazen Alnouti, Subodh M. Lele, Jamie L. Arnst, Stephanie K. Bunt, Paul M. Grandgenett, Ashley M. Mohr, Muhammad M. Anwar, Nagsen Gautam, Rajkumar N. Rajule, Elizabeth C. Blowers, Vashti C. Bryant, Prakash Radhakrishnan
PDF file - 53K, Table S1: Pancreatic cancer cell growth inhibition by 13-197; Table S2: % Neutrophils upon prolonged treatment with 13-197; Table S3: Metastases in mice treated with 13-197; Table S4: Immunohistochemical analysis of tumor samples; Tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185e2a480afe6b7e705894a807891a05
https://doi.org/10.1158/1078-0432.22450824
https://doi.org/10.1158/1078-0432.22450824
Autor:
Amarnath Natarajan, Michael A. Hollingsworth, Yazen Alnouti, Subodh M. Lele, Jamie L. Arnst, Stephanie K. Bunt, Paul M. Grandgenett, Ashley M. Mohr, Muhammad M. Anwar, Nagsen Gautam, Rajkumar N. Rajule, Elizabeth C. Blowers, Vashti C. Bryant, Prakash Radhakrishnan
Purpose: The presence of TNF-α in approximately 50% of surgically resected tumors suggests that the canonical NF-κB and the mTOR pathways are activated. Inhibitor of IκB kinase β (IKKβ) acts as the signaling node that regulates transcription via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bd695222652d54bd4967231ca44fe7
https://doi.org/10.1158/1078-0432.c.6522033
https://doi.org/10.1158/1078-0432.c.6522033
Autor:
Amarnath Natarajan, Michael A. Hollingsworth, Yazen Alnouti, Subodh M. Lele, Jamie L. Arnst, Stephanie K. Bunt, Paul M. Grandgenett, Ashley M. Mohr, Muhammad M. Anwar, Nagsen Gautam, Rajkumar N. Rajule, Elizabeth C. Blowers, Vashti C. Bryant, Prakash Radhakrishnan
PDF file - 76K, Dose and time dependent effect of 13-197 on Capan2 cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c643cb8363d6f2b61949b727efb5e6
https://doi.org/10.1158/1078-0432.22450827.v1
https://doi.org/10.1158/1078-0432.22450827.v1
Autor:
George R. Beck, Jamie L. Arnst
Publikováno v:
Biochem Pharmacol
Phosphorus, often in the form of inorganic phosphate (Pi), is critical to cellular function on many levels; it is required as an integral component of kinase signaling, in the formation and function of DNA and lipids, and energy metabolism in the for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c9a20069230b4cd4538a2adb764a55
https://europepmc.org/articles/PMC9667393/
https://europepmc.org/articles/PMC9667393/
Autor:
Benjamin G. Barwick, Jamie L. Arnst, Joshua S.K. Bell, Jeanne Kowalski, Brian Pedro, Sandra Seby, Jessica Konen, Bhakti Dwivedi, Adam I. Marcus, Rachel Commander, Paula M. Vertino, Tala O. Khatib, Christina M. Knippler, Janna K. Mouw, Emily R. Summerbell
Publikováno v:
Science Advances
Specialized leader cells use stable filopodia to create linear fibronectin tracks to promote collective cancer invasion.
Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored
Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991ed2b8d54a42351bc931f2c60d9d8e
https://doi.org/10.1126/sciadv.aaz6197
https://doi.org/10.1126/sciadv.aaz6197
Autor:
Jacob I. Contreras, Yogesh A. Sonawane, Amarnath Natarajan, Nicholas Palermo, Michel M. Ouellette, Jamie L. Arnst, Andrew O. Wahl, Ashley L. Hein, Margaret A. Taylor, Ying Yan
Publikováno v:
Oncotarget
Aberrant activation of Rho GTPase Rac1 has been observed in various tumor types, including pancreatic cancer. Rac1 activates multiple signaling pathways that lead to uncontrolled proliferation, invasion and metastasis. Thus, inhibition of Rac1 activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3119edb34d5d0414769ca21a6f4cdd6a
https://doi.org/10.18632/oncotarget.16656
https://doi.org/10.18632/oncotarget.16656
Autor:
Jelena Vukasinovic, James T. Shoemaker, Adam I. Marcus, Jamie L. Arnst, Katherine R. Richardson
Publikováno v:
Cancer Research. 79:54-54
Modeling tissues in vitro has long consisted of two-dimensional (2D) monolayer cultures grown in a dish, flask, or multi-well plate. While these methods remain adequate for some applications, the advent of personalized cancer therapies has necessitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f12540d513dda5841b263f710cc13998
https://doi.org/10.1158/1538-7445.am2019-54
https://doi.org/10.1158/1538-7445.am2019-54
Publikováno v:
Cancer Research. 79:1239-1239
Lung cancer is the leading cause of cancer-related deaths in the US with an overall 5-year survival of only 15-20%. Metastatic disease is a major contributor to poor survival and novel therapeutics that can selectively target invasive tumor cell popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc5e8d76c7d4996fedd635927544fd0
https://doi.org/10.1158/1538-7445.am2019-1239
https://doi.org/10.1158/1538-7445.am2019-1239