Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jamie L Shirley"'
Autor:
Thais B. Bertolini, Jamie L. Shirley, Irene Zolotukhin, Xin Li, Tsuneyasu Kaisho, Weidong Xiao, Sandeep R. P. Kumar, Roland W. Herzog
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Adeno associated viral (AAV) vectors have emerged as a preferred platform for in vivo gene replacement therapy and represent one of the most promising strategies to treat monogenetic disorders such as hemophilia. However, immune responses to gene tra
Externí odkaz:
https://doaj.org/article/2a3a6ab4719142409e8c223560c4bfa4
Autor:
Georgina D. Campelia, James N. Kirkpatrick, Patsy D. Treece, Jamie L. Shirley, Denise M. Dudzinski
Publikováno v:
The Journal of Clinical Ethics. 33:92-100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a68bbc7992dc40cc45b35cf60d6c76e4
https://doi.org/10.1086/jce2022332092
https://doi.org/10.1086/jce2022332092
Autor:
Roland W. Herzog, Laurence Morel, Cox Terhorst, Geoffrey D. Keeler, Irene Zolotukhin, Brad E. Hoffman, David M. Markusic, Jamie L. Shirley, Alexandra Sherman, Mark A. Wallet
Publikováno v:
Mol Ther
Adeno-associated virus (AAV) vectors are widely used in clinical gene therapy to correct genetic disease by in vivo gene transfer. Although the vectors are useful, in part because of their limited immunogenicity, immune responses directed at vector c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e245f2b975d04387b974b14d23e1cd28
https://doi.org/10.1016/j.ymthe.2019.11.011
https://doi.org/10.1016/j.ymthe.2019.11.011
Autor:
Chen Ling, John S.S. Butterfield, Sandeep R. P. Kumar, Moanaro Biswas, Roland W. Herzog, Cox Terhorst, Alexandra Sherman, Jamie L. Shirley
Publikováno v:
Hum Gene Ther Methods
Innate immune signals that promote B cell responses in gene transfer are generally ill-defined. In this study, we evaluate the effect of activating endosomal Toll-like receptors 7, 8, and 9 (TLR7, TLR7/8, and TLR9) on antibody formation during muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b639cf39720ee4250cba6a9b0116db8
https://doi.org/10.1089/hgtb.2019.013
https://doi.org/10.1089/hgtb.2019.013
Publikováno v:
The Journal of Immunology. 208:52.05-52.05
Programmed death ligand-1 (PD-L1) interaction with PD-1 on T cells limits immune activation to prevent immunopathology in healthy tissues and the development of autoimmunity. While ligation of PD-1 by PD-L1 leads to T cell-intrinsic PD-1 signaling, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::975ae7685c5c9c71b82773d913735c4b
https://doi.org/10.4049/jimmunol.208.supp.52.05
https://doi.org/10.4049/jimmunol.208.supp.52.05
Autor:
David Godfrey, Mark D. Siegel, Douglas B. White, Shannon S. Carson, Bernard Lo, J. Daryl Thornton, Mark R. Wicclair, Renee D. Stapleton, Jamie L. Shirley, Erin S. DeMartino, Paula Goodman-Crews, Thaddeus Mason Pope, Marshall B. Kapp, Lynette Cederquist, Andrew B. Cohen, Rebecca L. Sudore, Eric Widera, Anita J. Tarzian, Joshua Bennett, David Magnus, Lynn F. Reinke
Publikováno v:
American journal of respiratory and critical care medicine, vol 201, iss 10
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
Background and Rationale: ICU clinicians regularly care for patients who lack capacity, an applicable advance directive, and an available surrogate decision-maker. Although there is no consensus on terminology, we refer to these patients as “unrepr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f466b3b6478350ec6c508bfb5f8ddddc
https://escholarship.org/uc/item/4nz384ts
https://escholarship.org/uc/item/4nz384ts
Autor:
Brad E. Hoffman, George Q. Perrin, Sandeep R. P. Kumar, Geoffrey L. Rogers, Mark A. Wallet, Jamie L. Shirley, Etiena Basner-Tschakarjan, Arun Srivastava, Irene Zolotukhin, Moanaro Biswas, Roland W. Herzog, Alexandra Sherman, Cox Terhorst
Publikováno v:
Blood. 129:3184-3195
Adeno-associated virus (AAV) is a replication-deficient parvovirus that is extensively used as a gene therapy vector. CD8+ T-cell responses against the AAV capsid protein can, however, affect therapeutic efficacy. Little is known about the in vivo me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7508d8d204d01970ae749122e17bd4b
https://doi.org/10.1182/blood-2016-11-751040
https://doi.org/10.1182/blood-2016-11-751040
Publikováno v:
Annual Review of Nursing Research. 34:183-198
Emergency departments (EDs) serve a wide range of patient needs. A crucial aspect of safe and effective care in the ED is to appropriately transition patients to the next level of care. In most EDs, this disposition planning is done exclusively by ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec2d7e81b3ae30bc49482398277a445
https://doi.org/10.1891/0739-6686.34.183
https://doi.org/10.1891/0739-6686.34.183
Autor:
Jamie L. Shirley
Publikováno v:
Against-Medical-Advice Discharges from the Hospital ISBN: 9783319751290
Nursing has a key role in promoting positive outcomes for patients who seek AMA discharges. Their practice is informed by professional obligations to social justice and the ethics of care. Nurses can facilitate quality care for these patients by unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebb04739dd918b3354f43c3741b6270a
https://doi.org/10.1007/978-3-319-75130-6_6
https://doi.org/10.1007/978-3-319-75130-6_6
Autor:
Jamie L. Shirley, Meghan Eagen-Torkko
Publikováno v:
The American Journal of Bioethics. 17:96-98
Cases in which patients hold idiosyncratic beliefs that are at odds with the beliefs and practices of the health care provider are often challenging. Getting help from another perspective is useful...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b993d27fd199a031339fcbf3c210b3e8
https://doi.org/10.1080/15265161.2016.1251640
https://doi.org/10.1080/15265161.2016.1251640