Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jamie L P, Lim"'
Autor:
Ciara H. O’Flanagan, Kieran R. Campbell, Allen W. Zhang, Farhia Kabeer, Jamie L. P. Lim, Justina Biele, Peter Eirew, Daniel Lai, Andrew McPherson, Esther Kong, Cherie Bates, Kelly Borkowski, Matt Wiens, Brittany Hewitson, James Hopkins, Jenifer Pham, Nicholas Ceglia, Richard Moore, Andrew J. Mungall, Jessica N. McAlpine, The CRUK IMAXT Grand Challenge Team, Sohrab P. Shah, Samuel Aparicio
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Single-cell RNA sequencing (scRNA-seq) is a powerful tool for studying complex biological systems, such as tumor heterogeneity and tissue microenvironments. However, the sources of technical and biological variation in primary sol
Externí odkaz:
https://doaj.org/article/fa6f78c27ad142aba9a969b1f7cd721c
Autor:
Lien Hoang, Stefan Kommoss, Samuel Leung, Kendall Greening, Minh Bui, Aslı D Munzur, Sohrab P. Shah, James Hopkins, Jamie L. P. Lim, Evan W. Gibbard, Christine Chow, Angela S. Cheng, Maya DeGrood, Niki Boyd, David G. Huntsman, Dawn R. Cochrane, Vassilena Sharlandjieva, J Maxwell Douglas, Germain C. Ho, Daniel Lai, David Farnell, Jessica N. McAlpine, Friedrich Kommoss, Andrew Roth, Kieran R Campbell
Publikováno v:
The Journal of Pathology. 252:201-214
Endometrial carcinoma, the most common gynaecological cancer, develops from endometrial epithelium which is composed of secretory and ciliated cells. Pathologic classification is unreliable and there is a need for prognostic tools. We used single cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62e22c5831196fcda5534c4ad721429
https://doi.org/10.1002/path.5511
https://doi.org/10.1002/path.5511
Autor:
Ignacio Vázquez-García, Florian Uhlitz, Nicholas Ceglia, Jamie L. P. Lim, Michelle Wu, Neeman Mohibullah, Juliana Niyazov, Arvin Eric B. Ruiz, Kevin M. Boehm, Viktoria Bojilova, Christopher J. Fong, Tyler Funnell, Diljot Grewal, Eliyahu Havasov, Samantha Leung, Arfath Pasha, Druv M. Patel, Maryam Pourmaleki, Nicole Rusk, Hongyu Shi, Rami Vanguri, Marc J. Williams, Allen W. Zhang, Vance Broach, Dennis S. Chi, Arnaud Da Cruz Paula, Ginger J. Gardner, Sarah H. Kim, Matthew Lennon, Kara Long Roche, Yukio Sonoda, Oliver Zivanovic, Ritika Kundra, Agnes Viale, Fatemeh N. Derakhshan, Luke Geneslaw, Shirin Issa Bhaloo, Ana Maroldi, Rahelly Nunez, Fresia Pareja, Anthe Stylianou, Mahsa Vahdatinia, Yonina Bykov, Rachel N. Grisham, Ying L. Liu, Yulia Lakhman, Ines Nikolovski, Daniel Kelly, Jianjiong Gao, Andrea Schietinger, Travis J. Hollmann, Samuel F. Bakhoum, Robert A. Soslow, Lora H. Ellenson, Nadeem R. Abu-Rustum, Carol Aghajanian, Claire F. Friedman, Andrew McPherson, Britta Weigelt, Dmitriy Zamarin, Sohrab P. Shah
Publikováno v:
Nature. 612(7941)
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability1–4 patterned by distinct mutational processes5,6, tumour heterogeneity7–9 and intraperitoneal spread7,8,10. Immunotherapies have had limited efficacy in HGSOC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd08592c160754751e936ba40dbd607
https://pubmed.ncbi.nlm.nih.gov/36517593
https://pubmed.ncbi.nlm.nih.gov/36517593
Autor:
Allen W. Zhang, Mahsa Vahdatinia, Christopher J. Fong, Anthe Stylianou, Agnes Viale, Yonina Bykov, Arnaud Da Cruz Paula, Matthew Lennon, Fatemeh Derakhshan, Ignacio Vázquez-García, Tyler Funnell, M. Wu, Hongyu Shi, Rachel N. Grisham, Ana Maroldi, Nicole Rusk, Kevin M. Boehm, Ginger J. Gardner, Rahelly Nunez, Samuel F. Bakhoum, Neeman Mohibullah, Ying L Liu, Vance Broach, Arfath Pasha, Andrea Schietinger, Maryam Pourmaleki, Nadeem R. Abu-Rustum, Ines Nikolovski, Andrew McPherson, Dennis S. Chi, Daniel Kelly, Kara Long Roche, Oliver Zivanovic, Travis J. Hollmann, Claire F. Friedman, Luke Geneslaw, Rami Vanguri, Marc J Williams, Yukio Sonoda, Britta Weigelt, Nicholas Ceglia, Diljot Grewal, Florian Uhlitz, Carol Aghajanian, Robert A. Soslow, Sohrab P. Shah, Druv M. Patel, Ritika Kundra, Yulia Lakhman, Arvin Ruiz, Jianjiong Gao, Dmitriy Zamarin, Fresia Pareja, Viktoria Bojilova, Lora H. Ellenson, Jamie L. P. Lim, Eliyahu Havasov, Sarah H. Kim, Samantha Leung
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability patterned by distinct mutational processes, intratumoral heterogeneity and intraperitoneal spread. We investigated determinants of immune recognition and evasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecb1824833882d36702532910d35990
https://doi.org/10.1101/2021.08.24.454519
https://doi.org/10.1101/2021.08.24.454519
Autor:
Beatty S, Britta Weigelt, Havasov E, Douglas Jm, Beixi Wang, Samuel Aparicio, Steven McKinney, Samantha Leung, Hakwoo Lee, Brimhall J, Marc J Williams, Yang Li, Sohrab P. Shah, Justina Biele, Jamie L. P. Lim, Funnell T, Da Cruz Paula A, Ciara H. O'Flanagan, Andrew McPherson, Damian Yap, Nicholas Ceglia, Diljot Grewal, Weiner Ac, Sarah H. Kim, Allen Zhang, Ruiz de Algara T, Lee, Cerda Llanos, Liu Yf, Peter Eirew, Jorge S. Reis-Filho, Dmitriy Zamarin, Abrams D, Tehmina Masud, Daniel Lai, Bojilova, Richard A. Moore, Xu H, Farhia Kabeer, Nicole Rusk, Florian Uhlitz, Jerome Ting, Jenifer Pham
Structural genome alterations are determinants of cancer ontogeny and therapeutic response. While bulk genome sequencing has enabled delineation of structural variation (SV) mutational processes which generate patterns of DNA damage, we have little u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbca175098a6792741c75961dca47af5
https://doi.org/10.1101/2021.06.03.446999
https://doi.org/10.1101/2021.06.03.446999
Autor:
Tyler, Funnell, Ciara H, O'Flanagan, Marc J, Williams, Andrew, McPherson, Steven, McKinney, Farhia, Kabeer, Hakwoo, Lee, Sohrab, Salehi, Ignacio, Vázquez-García, Hongyu, Shi, Emily, Leventhal, Tehmina, Masud, Peter, Eirew, Damian, Yap, Allen W, Zhang, Jamie L P, Lim, Beixi, Wang, Jazmine, Brimhall, Justina, Biele, Jerome, Ting, Vinci, Au, Michael, Van Vliet, Yi Fei, Liu, Sean, Beatty, Daniel, Lai, Jenifer, Pham, Diljot, Grewal, Douglas, Abrams, Eliyahu, Havasov, Samantha, Leung, Viktoria, Bojilova, Richard A, Moore, Nicole, Rusk, Florian, Uhlitz, Nicholas, Ceglia, Adam C, Weiner, Elena, Zaikova, J Maxwell, Douglas, Dmitriy, Zamarin, Britta, Weigelt, Sarah H, Kim, Arnaud, Da Cruz Paula, Jorge S, Reis-Filho, Spencer D, Martin, Yangguang, Li, Hong, Xu, Teresa Ruiz, de Algara, So Ra, Lee, Viviana Cerda, Llanos, David G, Huntsman, Jessica N, McAlpine, Sohrab P, Shah, Pu, Zheng
Publikováno v:
Nature. 612(7938)
How cell-to-cell copy number alterations that underpin genomic instability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::baaf3b0746b71635075b84546a6965ab
https://pubmed.ncbi.nlm.nih.gov/36289342
https://pubmed.ncbi.nlm.nih.gov/36289342
Autor:
Sohrab P. Shah, Allen W. Zhang, Nicholas Ceglia, Samuel Aparicio, Daniel Lai, Peter Eirew, Justina Biele, Esther Kong, Richard D. Moore, Kieran R Campbell, Cherie Bates, Jamie L. P. Lim, Jenifer Pham, Matt Wiens, Kelly Borkowski, Andrew McPherson, Farhia Kabeer, Andrew J. Mungall, Ciara H. O'Flanagan, James Hopkins, Jessica N. McAlpine, Brittany Hewitson
Publikováno v:
Genome Biology
Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)
BackgroundSingle-cell RNA sequencing (scRNAseq) is a powerful tool for studying complex biological systems, such as tumour heterogeneity and tissue microenvironments. However, the sources of technical and biological variation in primary solid tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dfacc0c474158c0cc38d7e9e0d3faa
https://doi.org/10.1101/683227
https://doi.org/10.1101/683227
Autor:
Brittany Hewitson, Lauren Chong, Aoki T, Chan T, Jamie L. P. Lim, Allen W. Zhang, Sohrab P. Shah, Jessica N. McAlpine, Anja Mottok, Ciara H. O'Flanagan, Matt Wiens, Andrew McPherson, Weng Ap, Elizabeth A. Chavez, Wang X, Daniel Lai, Pascale Walters, Kieran R Campbell, Samuel Aparicio, Clémentine Sarkozy, Christian Steidl
Single-cell RNA sequencing (scRNA-seq) has transformed biomedical research, enabling decomposition of complex tissues into disaggregated, functionally distinct cell types. For many applications, investigators wish to identify cell types with known ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::080b2b2d282585ccd8acba410d5b5156
https://doi.org/10.1101/521914
https://doi.org/10.1101/521914
Autor:
Kieran R Campbell, Nicholas Ceglia, Xuehai Wang, Samuel Aparicio, Anja Mottok, Lauren Chong, Jamie L. P. Lim, Clémentine Sarkozy, Christian Steidl, Sohrab P. Shah, Andrew McPherson, Allen W. Zhang, Daniel Lai, Andrew P Weng, Brittany Hewitson, Tim Chan, Elizabeth A. Chavez, Pascale Walters, Tomohiro Aoki, Ciara H. O'Flanagan, Matt Wiens, Jessica N. McAlpine
Publikováno v:
Nat Methods
Single-cell RNA sequencing (scRNA-seq) has enabled decomposition of complex tissues into functionally distinct cell types. Often, investigators wish to assign cells to cell types, performed through unsupervised clustering followed by manual annotatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52882dcb323de1bba16c26dd9e28ef7d
https://pubmed.ncbi.nlm.nih.gov/31501550
https://pubmed.ncbi.nlm.nih.gov/31501550
Autor:
Friedrich Kommoss, Evan W. Gibbard, Samantha J. Neilson, Maya DeGrood, Samuel Leung, Kieran R Campbell, David Farnell, James Hopkins, Kendall Greening, Sohrab P. Shah, Germain C. Ho, Minh Bui, Dawn R. Cochrane, Jamie L. P. Lim, Jessica N. McAlpine, Daniel Lai, David G. Huntsman, Angela S. Cheng, Vassilena Sharlandjieva
Publikováno v:
Clinical Cancer Research. 26:B09-B09
Endometrial epithelium gives rise to both endometrial and ovarian cancers (of clear-cell and endometrioid subtypes), the latter arising from ectopic endometrium (endometriosis). Endometrial epithelium comprises mainly secretory cells, with a minor ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6a227c98e99c428f6dbd1663f380e8b
https://doi.org/10.1158/1557-3265.ovca19-b09
https://doi.org/10.1158/1557-3265.ovca19-b09