Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jamie L McCall"'
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0249442 (2021)
We previously demonstrated that exposure of adult mice to environmental levels of cadmium (Cd) alters immune cell development and function with increases in anti-streptococcal antibody levels, as well as decreases in splenic natural regulatory T cell
Externí odkaz:
https://doaj.org/article/04f7e17cd38d4040a4abaf4e9578d319
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209224 (2019)
The cell cycle is under circadian regulation. Oncogenes can dysregulate circadian-regulated genes to disrupt the cell cycle, promoting tumor cell proliferation. As a regulator of G2/M arrest in response to DNA damage, the circadian gene Timeless Circ
Externí odkaz:
https://doaj.org/article/4ff0954c4f614d8d8cb1388b07bab2c0
Autor:
Jamie L. McCall, Werner J. Geldenhuys, Lisa J. Robinson, Michelle R. Witt, Peter M. Gannett, Björn C. G. Söderberg, Harry C. Blair, Jonathan Soboloff, John B. Barnett
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract This study provides a detailed understanding of the preclinical pharmacokinetics and metabolism of ELP‐004, an osteoclast inhibitor in development for the treatment of bone erosion. Current treatments for arthritis, including biological di
Externí odkaz:
https://doaj.org/article/14ba5e5d547b4005a0abb7a8ff4e9e70
Autor:
Harry C Blair, Jonathan Soboloff, Irina L Tourkova, Jamie L. McCall, Suravi Ray, Margalit E Rosenkranz, Cristina Sobacchi, Lisa J Robinson, John B Barnett
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 7, p 248 (2024)
We review the abnormal bone turnover that is the basis of idiopathic inflammatory or rheumatoid arthritis and bone loss, with emphasis on Tumor Necrosis Factor-alpha (TNFα)-related mechanisms. We review selected data on idiopathic arthritis in juven
Externí odkaz:
https://doaj.org/article/8affe27a801d44a09bf66b64021e954b
Autor:
Jamie L. McCall, Melinda E. Varney, Emily Rice, Sebastian A. Dziadowicz, Casey Hall, Kathryn E. Blethen, Gangqing Hu, John B. Barnett, Ivan Martinez
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
ObjectivePrenatal cadmium (Cd) exposure leads to immunotoxic phenotypes in the offspring affecting coding and non-coding genes. Recent studies have shown that long non-coding RNAs (lncRNAs) are integral to T cell regulation. Here, we investigated the
Externí odkaz:
https://doaj.org/article/69de9cad5a064772b72aa5fc7945016a
Autor:
Beth K. Neilsen, Binita Chakraborty, Jamie L. McCall, Danielle E. Frodyma, Richard L. Sleightholm, Kurt W. Fisher, Robert E. Lewis
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract Background KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcription and DNA synthesi
Externí odkaz:
https://doaj.org/article/771d20c48057472cbc341e4bbb5bf0ab
Autor:
Michael DeGregorio, Michael Wolf, Jamie L. McCall, Katie E. Bell, Audrey Gutierrez, Stephen Griffey, Brittany E. Greenberg, Rebekah A. Burich, Gregory T. Wurz, Neelima R. Mehta
Purpose: In this study, we examine the immunomodulatory effects and antitumor activity of tamoxifen and letrozole when combined with the human epithelial mucin (hMUC1)-specific vaccine, L-BLP25, in the hMUC1-expressing mammary tumor (MMT) mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30dc0f9d4b42efe236ca91d19f561c1
https://doi.org/10.1158/1078-0432.c.6521114
https://doi.org/10.1158/1078-0432.c.6521114
Autor:
Michael DeGregorio, Michael Wolf, Jamie L. McCall, Katie E. Bell, Audrey Gutierrez, Stephen Griffey, Brittany E. Greenberg, Rebekah A. Burich, Gregory T. Wurz, Neelima R. Mehta
PDF file - 87K, Representative MMT tumors stained with H&E (A), ER-alpha IHC (B), and hMUC1 (C) (bar = 100 mu m)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c949bb05e6f99d15a52010c9219486
https://doi.org/10.1158/1078-0432.22447565
https://doi.org/10.1158/1078-0432.22447565
Autor:
Michael DeGregorio, Michael Wolf, Jamie L. McCall, Katie E. Bell, Audrey Gutierrez, Stephen Griffey, Brittany E. Greenberg, Rebekah A. Burich, Gregory T. Wurz, Neelima R. Mehta
PDF file - 87K, Kaplan-Meier survival curves comparing the vaccine alone treatment group with the tamoxifen (A), letrozole (B), and estradiol (C) plus vaccine combination treatment groups are shown (N=7, all groups)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62760b1c25af36c5d33616c3e71d3bea
https://doi.org/10.1158/1078-0432.22447562
https://doi.org/10.1158/1078-0432.22447562
Autor:
Michael DeGregorio, Michael Wolf, Jamie L. McCall, Katie E. Bell, Audrey Gutierrez, Stephen Griffey, Brittany E. Greenberg, Rebekah A. Burich, Gregory T. Wurz, Neelima R. Mehta
PDF file - 119K, Percentage cytotoxicity was measured in hMUC1 expressing breast cancer target cells (derived from an MMT tumor) after 60 min incubation with CD8 effectors derived from vaccinated/placebo or untreated mice. (A) CD8+ effector cells fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc31f11571b59df45ad20b47950d488
https://doi.org/10.1158/1078-0432.22447559
https://doi.org/10.1158/1078-0432.22447559