Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jamie K. Alan"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 6, Pp 1885-1895 (2018)
During development, neuronal cells extend an axon toward their target destination in response to a cue to form a properly functioning nervous system. Rho proteins, Ras-related small GTPases that regulate cytoskeletal organization and dynamics, cell a
Externí odkaz:
https://doaj.org/article/9530b415d6f14566a9d5248ca6614c83
Publikováno v:
Cancers, Vol 12, Iss 9, p 2683 (2020)
Polyunsaturated fatty acids (PUFAs) and non-steroidal anti-inflammatory drugs (NSAIDs) show anticancer activities through diverse molecular mechanisms. However, the anticancer capacities of either PUFAs or NSAIDs alone is limited. We examined whether
Externí odkaz:
https://doaj.org/article/d04d5fb025d345029ccfc665ebdb97b9
Publikováno v:
Small GTPases. 14:1-13
Publikováno v:
Small GTPases. 4(4)
Rho GTPases are key regulators of cellular protrusion and are involved in many developmental events including axon guidance during nervous system development. Rho GTPase pathways display functional redundancy in developmental events, including axon g
Autor:
Jamie K, Alan, Erik A, Lundquist
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 827
We provide information and protocols for the analysis of Rho GTPase function in axon pathfinding in Caenorhabditis elegans. The powerful molecular, genetic, imaging, and transgenic tools available in C. elegans make it an excellent system in which to
Autor:
Jamie K. Alan, Erik A. Lundquist
Publikováno v:
Methods in Molecular Biology ISBN: 9781617794414
We provide information and protocols for the analysis of Rho GTPase function in axon pathfinding in Caenorhabditis elegans. The powerful molecular, genetic, imaging, and transgenic tools available in C. elegans make it an excellent system in which to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b118b4a39a24ed5318e090bb878638
https://doi.org/10.1007/978-1-61779-442-1_22
https://doi.org/10.1007/978-1-61779-442-1_22
Autor:
Cercina Onesto, Dominico Vigil, Bentley R. Midkiff, Jamie K. Alan, Ellen V. Stevens, Lee M. Graves, Jinsong Liu, Natalie Banet, Nana Nikolaishvili-Feinberg, Channing J. Der, C. Ryan Miller, Ana Plachco, Pei Fen Kuan
Publikováno v:
Small GTPases. 2(4)
Previous studies described functional roles for Rho GDP dissociation inhibitor 2 (RhoGDI2) in bladder, gastric and breast cancers. However, only limited expression and no functional analyses have been done for RhoGDI2 in ovarian cancer. We determined
Autor:
Vanessa, González-Pérez, David J, Reiner, Jamie K, Alan, Cicely, Mitchell, Lloyd J, Edwards, Vladimir, Khazak, Channing J, Der, Adrienne D, Cox
Publikováno v:
Journal of Molecular Signaling
Background Activation of the mammalian Ras-Raf-MEK-ERK MAPK signaling cascade promotes cellular proliferation, and activating Ras mutations are implicated in cancer onset and maintenance. This pathway, a therapeutic target of interest, is highly cons
Publikováno v:
Cancer Genome and Tumor Microenvironment ISBN: 9781441907103
Unlike Ras proteins that are oncogenically mutated in 30% of human cancers, known naturally occurring mutations in Rho GTPases are limited to RhoH (a.k.a. ARHH). This gene has been found to be rearranged in non-Hodgkin’s lymphomas and multiple myel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e5f0830cb03d5c2cf19f69dfa56dd48
https://doi.org/10.1007/978-1-4419-0711-0_4
https://doi.org/10.1007/978-1-4419-0711-0_4
Publikováno v:
Molecular and cellular biology. 29(4)
Wrch-1, an atypical and transforming Rho GTPase, regulates cellular activities including proliferation and actin organization, but its functions and effectors remain poorly characterized. We show here that Wrch-1 distributes along the apical and baso