Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jamie Jarusiewicz"'
Publikováno v:
European Journal of Inorganic Chemistry. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62dd0df731fada1a0c3a1902c1dbce39
https://doi.org/10.1002/ejic.202200615
https://doi.org/10.1002/ejic.202200615
Autor:
Richard E. Lee, Jake Slavish, Brandon Young, Lei Yang, Sergio C. Chai, Marcus Fischer, Taosheng Chen, Zhenmei Li, Stephen W. White, Stanley Nithianantham, Jaeki Min, Gisele Nishiguchi, Seung Wook Yang, Patrick Ryan Potts, Marisa Actis, Shalandus H. Garrett, Jamie Jarusiewicz, Sourav Das, Martine F. Roussel, Barbara Jonchere, Anand Mayasundari, Yong Li, Mi-Kyung Yun, Xiang Fu, Fatemeh Keramatnia, Anang A. Shelat, Zoran Rankovic
Publikováno v:
Angew Chem Int Ed Engl
Targeting cereblon (CRBN) is currently one of the most frequently reported proteolysis-targeting chimera (PROTAC) approaches, owing to favorable drug-like properties of CRBN ligands, immunomodulatory imide drugs (IMiDs). However, IMiDs are known to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffb235e447bf310701a7f1aa84dd193
https://doi.org/10.1002/anie.202108848
https://doi.org/10.1002/anie.202108848
Autor:
Jianzhong Hu, Jamie Jarusiewicz, Guoqing Du, Gisele Nishiguchi, Satoshi Yoshimura, John C. Panetta, Zhenhua Li, Jaeki Min, Lei Yang, Divyabharathi Chepyala, Marisa Actis, Noemi Reyes, Brandon Smart, Ching-Hon Pui, David T. Teachey, Zoran Rankovic, Jun J. Yang
Publikováno v:
Sci Transl Med
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy and there is an unmet need for targeted therapies, especially for patients with relapsed disease. We have recently identified pre-T cell receptor (preTCR) and lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3dea83bbeb77aedc36c3467b7f609ba
https://europepmc.org/articles/PMC9730446/
https://europepmc.org/articles/PMC9730446/
Autor:
Zoran Rankovic, Barbara Jonchere, Junmin Peng, Martine F. Roussel, Anand Mayasundari, Sourav Das, Gisele Nishiguchi, Shalandus H. Garrett, Shondra Miller, Jeanine E. Price, Kiran Kodali, Fatemeh Keramatnia, Divyabharathi Chepyala, Lei Yang, James B Papizan, Jaeki Min, Marcus Fischer, P. Jake Slavish, Marisa Actis, Kevin McGowan, Charles G. Mullighan, Yong Li, Xiang Fu, Jamie Jarusiewicz, Brandon Young, Yunchao Chang
Publikováno v:
Journal of Medicinal Chemistry
Whereas the PROTAC approach to target protein degradation greatly benefits from rational design, the discovery of small-molecule degraders relies mostly on phenotypic screening and retrospective target identification efforts. Here, we describe the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666941d34c5223c407c9284840558645
https://doi.org/10.1021/acs.jmedchem.0c01313
https://doi.org/10.1021/acs.jmedchem.0c01313
Autor:
Jianzhong Hu, Jamie Jarusiewicz, Jaeki Min, Lei Yang, Divyabharathi Chepyala, Marisa Actis, Guoqing Du, Brandon Smart, Dylan Maxwell, Boer Xie, Satoshi Yoshimura, Junming Peng, David T. Teachey, Zoran Rankovic, Jun J. Yang
Publikováno v:
Cancer Research. 82:423-423
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer, with a particularly dismal prognosis in patients with relapsed diseases. Our group recently discovered LCK dependency as a therapeutic vulnerability in 33% of T-ALL and LCK inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9284b9b12b01320b648f83bbce4716
https://doi.org/10.1158/1538-7445.am2022-423
https://doi.org/10.1158/1538-7445.am2022-423
Autor:
Kathryn G. Roberts, Lisa J Alcock, Lauren Rowland, Divyabharathi Chepyala, Mark R. Litzow, Elisabeth Paietta, Jamie Jarusiewicz, Baranda S Hansen, Lei Yang, Yunchao Chang, Shondra M. Pruett-Miller, Randolph Larsen, Toshihiko Imamura, Aman Seth, Zoran Rankovic, Koshi Akahane, Dylan Maxwell, Jaeki Min, Shanshan Yu-Chen Bradford, Jun J. Yang, Marisa Actis, Chunxu Qu, Charles G. Mullighan, Stanley Nithianantham, Marcus Fischer, Anand Mayasundari, Hiroaki Goto
Publikováno v:
Blood
CRLF2-rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) accounts for more than half of Philadelphia chromosome-like (Ph-like) ALL and is associated with a poor outcome in children and adults. Overexpression of CRLF2 results in activation of Janu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60f9c122b0bb42ac2efdec667c29170
https://pubmed.ncbi.nlm.nih.gov/34882211
https://pubmed.ncbi.nlm.nih.gov/34882211
Autor:
Jianzhong Hu, Jaeki Min, Marisa Actis, Satoshi Yoshimura, Divyabharathi Chepyala, Zoran Rankovic, Jamie Jarusiewicz, Jun J. Yang, Dylan Maxwell, David T. Teachey, Lauren Rowland, Guoqing Du, Junmin Peng, Boer Xie, Lei Yang, Brandon Smart
Publikováno v:
Blood. 138:867-867
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy for which novel therapies are much needed especially in patients with relapsed diseases. By combining large-scale ex vivo pharmacotype profiling with network-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b0c93205adc65680e010222de70c6a1
https://doi.org/10.1182/blood-2021-147024
https://doi.org/10.1182/blood-2021-147024
Autor:
Jamie Jarusiewicz, Lei Yang, Yizhe Chen, Sharyn D. Baker, Jae Yoon Jeon, Michele Connelly, R. Kiplin Guy
Publikováno v:
ACS Omega
ACS Omega, Vol 2, Iss 5, Pp 1985-2009 (2017)
ACS Omega, Vol 2, Iss 5, Pp 1985-2009 (2017)
Profiling of the kinase-binding capabilities of an aminopyrimidine analogue detected in a cellular screen of the St. Jude small-molecule collection led to the identification of a novel series of FMS-like tyrosine kinase 3 (FLT3) inhibitors. Structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2315d6bd9653672485d20ac153fc5a8
https://doi.org/10.1021/acsomega.7b00144
https://doi.org/10.1021/acsomega.7b00144
Autor:
Shaohui Yin, Tian Zhu, Susan Boyle-Vavra, Kirk E. Hevener, Isabel Ojeda, Jamie Jarusiewicz, Jinhong Ren, Lalit Kumar Sharma, Richard E. Lee, Michael E. Johnson, Daniel Hoagland, Hyun Lee, Robert S. Daum
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Methicillin-resistant Staphylococcus aureus (MRSA) strains that are resistant to all forms of penicillin have become an increasingly common and urgent problem threatening human health. They are responsible for a wide variety of infectious diseases ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ab6ba95e61cfa18953a689d7e3bd98a
https://doi.org/10.1128/aac.02593-18
https://doi.org/10.1128/aac.02593-18
Autor:
Jun Ye, Tao Gao, Ju He, Michael A. Philips, Raja Dey, Jamie Jarusiewicz, Kevin J. Gaffney, Aidong Han, Lin Chen, Xiao Lei, Kaori Noridomi, Nicos A. Petasis, Nimanthi Jayathilaka
Publikováno v:
Nucleic Acids Research
Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development of epigenetic modulators, however, has been largely limited to direct targeting of catalytic active site conser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e971092b8ed33e92ac3c2cbacab73d
http://europepmc.org/articles/PMC3384312
http://europepmc.org/articles/PMC3384312