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pro vyhledávání: '"Jamie J. L. Williams"'
Autor:
Jamie J. L. Williams, Nasser Alotaiq, William Mullen, Richard Burchmore, Libin Liu, George S. Baillie, Fred Schaper, Paul F. Pilch, Timothy M. Palmer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
SOCS3 is an important negative feedback inhibitor of JAK–STAT-mediated cytokine signalling. Here the authors implicate cavin-1 — an essential component of caveolae — in the recruitment of SOCS3 to the plasma membrane to prevent sustained cytoki
Externí odkaz:
https://doaj.org/article/150955b131d248018bd4158e8688ea0e
Publikováno v:
Cells, Vol 3, Iss 2, Pp 546-562 (2014)
The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention
Externí odkaz:
https://doaj.org/article/dab2639b785049aca48925afaf4b2642
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2169
The ability of inducible regulator suppressor of cytokine signaling 3 (SOCS3) to inhibit Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling requires interaction with specific cytokine receptors, JAKs, and components of