Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Jamie J. Arnold"'
Autor:
Haley S. Caldwell, Lili Kuo, Janice D. Pata, Alan P. Dupuis, II, Jamie J. Arnold, Calvin Yeager, Jessica Stout, Cheri A. Koetzner, Anne F. Payne, Sean M. Bialosuknia, Elyse M. Banker, Taylor A. Nolen, Craig E. Cameron, Alexander T. Ciota
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107468- (2023)
Summary: West Nile virus (WNV), the most prevalent arthropod-borne virus (arbovirus) in the United States, is maintained in a cycle between Culex spp. mosquitoes and birds. Arboviruses exist within hosts and vectors as a diverse set of closely relate
Externí odkaz:
https://doaj.org/article/5e2f8446e68f46e881c8b8277abf0dbe
Autor:
Feng Guo, Sixing Li, Mehmet Umut Caglar, Zhangming Mao, Wu Liu, Andrew Woodman, Jamie J. Arnold, Claus O. Wilke, Tony Jun Huang, Craig E. Cameron
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1692-1704 (2017)
Summary: We have developed a high-throughput, microfluidics-based platform to perform kinetic analysis of viral infections in individual cells. We have analyzed thousands of individual poliovirus infections while varying experimental parameters, incl
Externí odkaz:
https://doaj.org/article/e63e3159a3204ca99091d9da1d76c847
Autor:
David Dulin, Jamie J. Arnold, Theo van Laar, Hyung-Suk Oh, Cheri Lee, Angela L. Perkins, Daniel A. Harki, Martin Depken, Craig E. Cameron, Nynke H. Dekker
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 1063-1076 (2017)
Summary: RNA viruses pose a threat to public health that is exacerbated by the dearth of antiviral therapeutics. The RNA-dependent RNA polymerase (RdRp) holds promise as a broad-spectrum, therapeutic target because of the conserved nature of the nucl
Externí odkaz:
https://doaj.org/article/4bf1a74ecce14305982ecd8c80a25e31
Autor:
Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron, David D. Boehr
Publikováno v:
Viruses, Vol 7, Iss 10, Pp 5571-5586 (2015)
The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp). We have previously shown that the T362I substitution leads to a lower fidelity
Externí odkaz:
https://doaj.org/article/c60928dadd524e628c2c6fd8d09b5fe9
Publikováno v:
BioTechniques, Vol 27, Iss 3, Pp 450-456 (1999)
Externí odkaz:
https://doaj.org/article/1bcc9dc9eb1146b4b1b851bf6b723cdd
Autor:
Mona Seifert, Subhas C Bera, Pauline van Nies, Robert N Kirchdoerfer, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Xiangzhi Meng, Hongjie Xia, James M Wood, Lawrence D Harris, Flavia S Papini, Jamie J Arnold, Steven Almo, Tyler L Grove, Pei-Yong Shi, Yan Xiang, Bruno Canard, Martin Depken, Craig E Cameron, David Dulin
Publikováno v:
eLife, Vol 10 (2021)
The absence of ‘shovel-ready’ anti-coronavirus drugs during vaccine development has exceedingly worsened the SARS-CoV-2 pandemic. Furthermore, new vaccine-resistant variants and coronavirus outbreaks may occur in the near future, and we must be r
Externí odkaz:
https://doaj.org/article/3f924b912930433ba8d5da28b1275015
Autor:
Misha Klein, Subhas C. Bera, Thomas K. Anderson, Bing Wang, Flavia S. Papini, Jamie J. Arnold, Craig E. Cameron, Martin Depken, Robert N. Kirchdoerfer, Irina Artsimovitch, David Dulin
Publikováno v:
Biophysical Journal, 122(3 Supplement 1), 171a-171a. Biophysical Society
Klein, M, Bera, S C, Anderson, T K, Wang, B, Papini, F S, Arnold, J J, Cameron, C E, Depken, M, Kirchdoerfer, R N, Artsimovitch, I & Dulin, D 2023, ' Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex ', Biophysical Journal, vol. 122, no. 3 Supplement 1, pp. 171a-171a . https://doi.org/10.1016/j.bpj.2022.11.1071
Klein, M, Bera, S C, Anderson, T K, Wang, B, Papini, F S, Arnold, J J, Cameron, C E, Depken, M, Kirchdoerfer, R N, Artsimovitch, I & Dulin, D 2023, ' Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex ', Biophysical Journal, vol. 122, no. 3 Supplement 1, pp. 171a-171a . https://doi.org/10.1016/j.bpj.2022.11.1071
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb8339eb4a500aacda2e6045c01b27b
https://research.vu.nl/en/publications/b815bc2f-c880-41dc-a5f6-3840c02196a0
https://research.vu.nl/en/publications/b815bc2f-c880-41dc-a5f6-3840c02196a0
Autor:
Hyejeong Kim, David Aponte-Diaz, Mohamad S. Sotoudegan, Djoshkun Shengjuler, Jamie J. Arnold, Craig E. Cameron
RNA recombination in positive-strand RNA viruses is a molecular-genetic process, which permits the greatest evolution of the genome and may be essential to stabilizing the genome from the deleterious consequences of accumulated mutations. Enterovirus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee4e1eafee7a5d19c048a25d343326c
Autor:
Rukesh Chinthapatla, Mohamad Sotoudegan, Pankaj Srivastava, Thomas K Anderson, Ibrahim M Moustafa, Kellan T Passow, Samantha A Kennelly, Ramkumar Moorthy, David Dulin, Joy Y Feng, Daniel A Harki, Robert N Kirchdoerfer, Craig E Cameron, Jamie J Arnold
Publikováno v:
Nucleic acids research.
Some of the most efficacious antiviral therapeutics are ribonucleos(t)ide analogs. The presence of a 3′-to-5′ proofreading exoribonuclease (ExoN) in coronaviruses diminishes the potency of many ribonucleotide analogs. The ability to interfere wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fd92610460d7ec54c97c5850c8566a
https://pubmed.ncbi.nlm.nih.gov/35982684
https://pubmed.ncbi.nlm.nih.gov/35982684
Autor:
Calvin Yeager, Griffin Carter, David W Gohara, Neela H Yennawar, Eric J Enemark, Jamie J Arnold, Craig E Cameron
Publikováno v:
Nucleic acids research. 50(20)
The enteroviral 2C protein is a therapeutic target, but the absence of a mechanistic framework for this enzyme limits our understanding of inhibitor mechanisms. Here, we use poliovirus 2C and a derivative thereof to elucidate the first biochemical me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5362dd8040f9f14eb629431221d937
https://pubmed.ncbi.nlm.nih.gov/36399514
https://pubmed.ncbi.nlm.nih.gov/36399514