Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jamie Inshaw"'
Autor:
Joanna C Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I Temkin, Nathalia De Vasconcelos, Iker Valle Aramburu, Dennis Hoving, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Lena Lippert, Elisa Theresa Helbig, Florian Kurth, Bryan Williams, Aiden Flynn, Pauline T Lukey, Veronique Birault, Venizelos Papayannopoulos
Publikováno v:
eLife, Vol 12 (2024)
Background: Prinflammatory extracellular chromatin from neutrophil extracellular traps (NETs) and other cellular sources is found in COVID-19 patients and may promote pathology. We determined whether pulmonary administration of the endonuclease dorna
Externí odkaz:
https://doaj.org/article/aa0642bdfc68412890699c84f062b563
Autor:
Alan Kivitz, Wesley DeHaan, Rehan Azeem, Justin Park, Sheri Rhodes, Jamie Inshaw, Sheldon S. Leung, Savvas Nicolaou, Lloyd Johnston, Takashi K. Kishimoto, Peter G. Traber, Earl Sands, Hyon Choi
Publikováno v:
Rheumatology and Therapy, Vol 10, Iss 4, Pp 825-847 (2023)
Abstract Introduction SEL-212 is a developmental treatment for uncontrolled gout characterized by serum uric acid (sUA) levels ≥ 6 mg/dl despite treatment. It comprises a novel PEGylated uricase (SEL-037; also called pegadricase) co-administered wi
Externí odkaz:
https://doaj.org/article/cf6f1cb3ba274f37b044035ffe0ee7d4
Autor:
Karina Butler, Jamie Inshaw, Deborah Ford, Sarah Bernays, Karen Scott, Julia Kenny, Nigel Klein, Anna Turkova, Lynda Harper, Eleni Nastouli, Sara Paparini, Rahela Choudhury, Tim Rhodes, Abdel Babiker, Diana Gibb, on behalf of the PENTA team
Publikováno v:
Health Technology Assessment, Vol 20, Iss 49 (2016)
Background: For human immunodeficiency virus (HIV)-infected adolescents facing lifelong antiretroviral therapy (ART), short-cycle therapy (SCT) with long-acting agents offers the potential for drug-free weekends, less toxicity, better adherence and c
Externí odkaz:
https://doaj.org/article/d06c39e39e004a3f81c46eb7f6a17c43
Autor:
Jamie Inshaw, Clifford Leen, Martin Fisher, Richard Gilson, David Hawkins, Simon Collins, Julie Fox, Ken McLean, Sarah Fidler, Andrew Phillips, Sam Lattimore, Abdel Babiker, Kholoud Porter, UK HIV Seroconverters Cohort
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132772 (2015)
IntroductionThe effect of HCV infection on HIV disease progression remains unclear; the effect of HCV infection duration on HIV disease progression is unknown.MethodsWe used data from a cohort of HIV seroconverters to investigate the effect of HCV in
Externí odkaz:
https://doaj.org/article/4b308d37389c4f6e9ab579179309a263
Autor:
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I. Temkin, Nathalia De Vasconcelos, Iker Valle Aramburu, Dennis Hoving, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Bryan Williams, Aiden Flynn, Pauline T Lukey, Veronique Birault, Venizelos Papayannopoulos
BackgroundSARS-CoV2 infection causes severe, life-threatening pneumonia. Hyper-inflammation, coagulopathy and lymphopenia are associated with pathology and poor outcomes in these patients. Cell-free (cf) DNA is prominent in COVID-19 patients, amplifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86dfe7d4ab8b1c52fd3a97d5be18ddbe
https://doi.org/10.1101/2022.04.14.22272888
https://doi.org/10.1101/2022.04.14.22272888
Autor:
Jamie Inshaw, Fabio Busonero, Eleonora Porcu, Maristella Pitzalis, Eleonora Cocco, Margherita Chessa, Helen M. Colhoun, Annalisa Loizedda, Marco Masala, Gonçalo R. Abecasis, Maria Giovanna Marrosu, Lidia Leoni, Carlo Sidore, Mario Lovicu, Annapaola Frongia, David Schlessinger, Sandra Lai, Nicolò Curreli, Andrea Maschio, Lenuta Balaci, Liana Ap Ferreli, Fausto Pier'Angelo Poddie, Francesca Virdis, Suna Onengut-Gumuscu, John A. Todd, Michele Marongiu, Valeria Orrù, Maria Rossella Ricciardi, Magdalena Zoledziewska, Antonello Pani, Mariano Dei, Stephen S. Rich, Francesca Deidda, Jessica Frau, Mauro Pala, Nazario Olla, Paola Ferrigno, Edoardo Fiorillo, Gabriella Sole, Alessandro P Delitala, Valentina Serra, Francesco Loi, Stuart J. McGurnaghan, Maristella Steri, Maria Grazia Pilia, Antonella Mulas, Matteo Floris, Francesco Cucca, Luisa Mereu, Catherine C. Robertson
Publikováno v:
Mult Scler
Background: Defective alleles within the PRF1 gene, encoding the pore-forming protein perforin, in combination with environmental factors, cause familial type 2 hemophagocytic lymphohistiocytosis (FHL2), a rare, severe autosomal recessive childhood d
Autor:
John A. Todd, Niina Sandholm, Marcin L. Pekalski, Antony J. Cutler, Arcadio Rubio García, Jamie Inshaw
We recently mapped a genetic susceptibility locus on chromosome 6q22.33 for type 1 diabetes diagnosed below age of 7 years near the gene Protein tyrosine phosphatase receptor type K (PTPRK) and the thymocyte selection associated gene (THEMIS). As the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01085b80c13a64a43f7807d5566b1272
https://doi.org/10.1101/2021.09.17.460789
https://doi.org/10.1101/2021.09.17.460789
Autor:
Joerg Hager, Benjamin P. Fairfax, Anthony C. Davison, Hélène Ruffieux, Sylvia Richardson, Leonardo Bottolo, Jamie Inshaw
Publikováno v:
Ann Appl Stat
Ann. Appl. Stat. 14, no. 2 (2020), 905-928
Ann. Appl. Stat. 14, no. 2 (2020), 905-928
We tackle modelling and inference for variable selection in regression problems with many predictors and many responses. We focus on detecting hotspots, that is, predictors associated with several responses. Such a task is critical in statistical gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eec06ab2f102c17d5f4dd95072a45ac
https://europepmc.org/articles/PMC7612176/
https://europepmc.org/articles/PMC7612176/
Publikováno v:
Diabetologia
Aims/hypothesis The genetic risk of type 1 diabetes has been extensively studied. However, the genetic determinants of age at diagnosis (AAD) of type 1 diabetes remain relatively unexplained. Identification of AAD genes and pathways could provide ins
Publikováno v:
European Journal of Human Genetics
Transcriptome imputation has become a popular method for integrating genotype data with publicly available expression data to investigate the potentially causal role of genes in complex traits. Here, we compare three approaches (PrediXcan, MetaXcan a