Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jamie I. Scott"'
Autor:
Jamie I. Scott, Lorena Mendive-Tapia, Doireann Gordon, Nicole D. Barth, Emily J. Thompson, Zhiming Cheng, David Taggart, Takanori Kitamura, Alberto Bravo-Blas, Edward W. Roberts, Jordi Juarez-Jimenez, Julien Michel, Berber Piet, I. Jolanda de Vries, Martijn Verdoes, John Dawson, Neil O. Carragher, Richard A. O’ Connor, Ahsan R. Akram, Margaret Frame, Alan Serrels, Marc Vendrell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Granzyme B is found in activated T cells and can be used as a marker of T cell activation. Here, the authors generate a fluorescent probe that can detect Granzyme B levels in tumours, and has the potential to be used as a biomarker of response to imm
Externí odkaz:
https://doaj.org/article/773a1c7cda434f51a8e1ac084abce313
Autor:
Asta Valančiūtė, Layla Mathieson, Richard A. O’Connor, Jamie I. Scott, Marc Vendrell, David A. Dorward, Ahsan R. Akram, Kevin Dhaliwal
Publikováno v:
Cancers, Vol 14, Iss 17, p 4119 (2022)
Augmenting T cell mediated tumor killing via immunogenic cancer cell death (ICD) is the cornerstone of emerging immunotherapeutic approaches. We investigated the potential of methylene blue photodynamic therapy (MB-PDT) to induce ICD in human lung ca
Externí odkaz:
https://doaj.org/article/307052b9f7b347d494c65390a4a909d9
Autor:
Jun Wu, Lutz Ackermann, Matteo Virelli, Wei Wang, Rositha Kuniyil, Marc Vendrell, Giuseppe Zanoni, Jamie I. Scott, Antonio Fernandez
Publikováno v:
Virelli, M, Wang, W, Kuniyil, R, Wu, J, Zanoni, G, Fernandez Vargas, A, Scott, J, Vendrell Escobar, M & Ackermann, L 2019, ' BODIPY-Labeled Cyclobutanes by Secondary C(sp3)─H Arylations for Live-Cell Imaging ', Chemistry-A European Journal . https://doi.org/10.1002/chem.201903461
Chemistry – A European Journal
Chemistry – A European Journal
Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3 )-H activation, exploiting chelation assistance by modular triazoles. The C-H arylation led to cyclobutane natural product derivatives in a highly regioselective f
Autor:
Gabriela B.P. Souza, Eufrânio N. da Silva Júnior, Richard J. Mellanby, Zhiming Cheng, Nicole D. Barth, Wagner O. Valença, Fabio de Moliner, Gleiston G. Dias, Jamie I. Scott, Marc Vendrell
Publikováno v:
Cheng, Z, Valenca, W O, Dias, G G, Scott, J, Barth, N D, De Moliner, F, Souza, G B P, Mellanby, R, da Silva Junior, E N & Vendrell Escobar, M 2019, ' Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues ', Bioorganic and Medicinal Chemistry . https://doi.org/10.1016/j.bmc.2019.07.017
Bioorganic & Medicinal Chemistry
Bioorganic & Medicinal Chemistry
Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally
Autor:
Richard J, Mellanby, Jamie I, Scott, Iris, Mair, Antonio, Fernandez, Louise, Saul, Jochen, Arlt, Monica, Moral, Marc, Vendrell
Publikováno v:
Chemical Science
Tricarbocyanine N-triazoles are first described as rationally-designed structures to overcome the limitations of NIR dyes for long-term in vivo imaging.
Herein tricarbocyanine N-triazoles are first described as a rationally-designed near-infrare
Herein tricarbocyanine N-triazoles are first described as a rationally-designed near-infrare
Autor:
Jamie I. Scott, Jan H. van Maarseveen, Henk Hiemstra, Suze E. M. Telderman, Roy P. M. van Santen, Arjen C. Breman, Steen Ingemann
Publikováno v:
ChemInform. 47
Sulfa-Michael additions to α,β-unsaturated N-acylated oxazolidin-2-ones and related α,β-unsaturated α-amino acid derivatives have been enantioselectively catalyzed by Cinchona alkaloids functionalized with a hydrogen bond donating group at the C
Publikováno v:
Scott, J, Deng, Q & Vendrell, M 2021, ' Near-infrared fluorescent probes for the detection of cancer-associated proteases ', Acs chemical biology . https://doi.org/10.1021/acschembio.1c00223
ACS Chemical Biology
ACS Chemical Biology
Proteases are enzymes capable of catalysing protein breakdown, which is critical across many biological processes. There are several families of proteases, each of which perform key functions through the degradation of specific proteins. As our under
Autor:
Emily J. Thompson, Sara Gutkin, Marc Vendrell, Doron Shabat, Takanori Kitamura, Ori Green, Jamie I. Scott
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Scott, J, Gutkin, S, Green, O, Thompson, E J, Kitamura, T, Shabat, D & Vendrell, M 2020, ' A Functional Chemiluminescent Probe for in vivo Imaging of Natural Killer Cell Activity against Tumours ', Angewandte Chemie International Edition . https://doi.org/10.1002/anie.202011429
Angewandte Chemie International Edition
Scott, J, Gutkin, S, Green, O, Thompson, E J, Kitamura, T, Shabat, D & Vendrell, M 2020, ' A Functional Chemiluminescent Probe for in vivo Imaging of Natural Killer Cell Activity against Tumours ', Angewandte Chemie International Edition . https://doi.org/10.1002/anie.202011429
Natural killer (NK) cells are immune cells that can kill certain types of cancer cells. Adoptive transfer of NK cells represents a promising immunotherapy for malignant tumours; however, there is a lack of methods to validate anti‐tumour activity o
Autor:
Zhiming Cheng, Emily J Thompson, Lorena Mendive‐Tapia, Jamie I Scott, Sam Benson, Takanori Kitamura, Ana Senan‐Salinas, Youhani Samarakoon, Edward W Roberts, Maykel A Arias, Julian Pardo, Eva M Galvez, Marc Vendrell
Publikováno v:
Cheng, Z, Thompson, E J, Mendive-tapia, L, Scott, J I, Benson, S, Kitamura, T, Senan-salinas, A, Samarakoon, Y, Roberts, E W, Arias, M A, Pardo, J, Galvez, E M & Vendrell, M 2022, ' Fluorogenic Granzyme A Substrates Enable Real-Time Imaging of Adaptive Immune Cell Activity ', Angewandte Chemie International Edition . https://doi.org/10.1002/anie.202216142
6 figures.
Cytotoxic immune cells, including T lymphocytes (CTLs) and natural killer (NK) cells, are essential components of the host response against tumors. CTLs and NK cells secrete granzyme A (GzmA) upon recognition of cancer cells; however,
Cytotoxic immune cells, including T lymphocytes (CTLs) and natural killer (NK) cells, are essential components of the host response against tumors. CTLs and NK cells secrete granzyme A (GzmA) upon recognition of cancer cells; however,