Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Jamie Heimburg"'
Autor:
Kentaro Kato, Jamie Heimburg-Molinaro
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/09ff31f7289a4007b7862c7f9ff4e610
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The aberrant expression of the Tn antigen (CD175) on surface glycoproteins of human carcinomas is associated with tumorigenesis, metastasis, and poor survival. To target this antigen, we developed Remab6, a recombinant, human chimeric anti-T
Externí odkaz:
https://doaj.org/article/01cfb96787654f6dbd1f2269d5c6b94b
Autor:
Gabrielle E. Dombek, Ana Sofia Ore, Jane Cheng, Yasuyuki Matsumoto, Jonathan N. Glickman, Aaron Fleishman, Jamie Heimburg-Molinaro, Vitaliy Y. Poylin, Anne Fabrizio, Thomas Cataldo, Evangelos Messaris, Richard D. Cummings
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background The Tn antigen (CD175) is an O-glycan expressed in various types of human adenocarcinomas, including colorectal cancer (CRC), though prior studies have relied heavily upon poorly characterized in-house generated antibodies and lec
Externí odkaz:
https://doaj.org/article/751b4525ac7c43088a77b3e3d0b804ce
Autor:
Nina Salinger Prasanphanich, Kristoffer Leon, W. Evan Secor, Charles B. Shoemaker, Jamie Heimburg-Molinaro, Richard D. Cummings
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Schistosomiasis is a globally prevalent, debilitating disease that is poorly controlled by chemotherapy and for which no vaccine exists. While partial resistance in people may develop over time with repeated infections and treatments, some animals, i
Externí odkaz:
https://doaj.org/article/22318064191b4810b15395dc8a6d3cd6
Autor:
Tanya R. McKitrick, Steffen M. Bernard, Alexander J. Noll, Bernard C. Collins, Christoffer K. Goth, Alyssa M. McQuillan, Jamie Heimburg-Molinaro, Brantley R. Herrin, Ian A. Wilson, Max D. Cooper, Richard D. Cummings
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
McKitrick et al engineer and characterize a novel lamprey antibody that recognizes terminal sulfated galactose epitopes on mammalian glycoproteins. This provides a new tool for the exploration of glycoprotein sulfation in mammalian cells, which could
Externí odkaz:
https://doaj.org/article/fc44f226d9cf4dce8756ecf26052d69b
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2260-2271 (2020)
Glycans are one of the major biological polymers found in the mammalian body. They play a vital role in a number of physiologic and pathologic conditions. Glycan microarrays allow a plethora of information to be obtained on protein–glycan binding i
Externí odkaz:
https://doaj.org/article/aaf2d354acb242269e28e45e77abe7a7
Autor:
Chao Gao, Mohui Wei, Tanya R. McKitrick, Alyssa M. McQuillan, Jamie Heimburg-Molinaro, Richard D. Cummings
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Glycans and glycan binding proteins (GBPs or lectins) are essential components in almost every aspect of immunology. Investigations of the interactions between glycans and GBPs have greatly advanced our understanding of the molecular basis of these f
Externí odkaz:
https://doaj.org/article/62f6525388b741618a670063b1264f92
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
This focused chapter serves as a short survey of glycan microarrays that are available with sialylated glycans, including both defined and shotgun arrays, their generation, and their utility in studying differential binding interactions to sialylated
Externí odkaz:
https://doaj.org/article/57afd4043246462caa5d01b89a780490
Autor:
Jamie Heimburg-Molinaro, Adel Almogren, Susan Morey, Olga V. Glinskii, Rene Roy, Gregory E. Wilding, Richard P. Cheng, Vladislav V. Glinsky, Kate Rittenhouse-Olson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 8, Pp 780-792 (2009)
The tumor-associated carbohydrate Thomsen-Friedenreich antigen (TF-Ag; Galß1-3GalNAcα-O-Ser/Thr) is overexpressed on the cell surface of several types of tumor cells, contributing to cancer cell adhesion and metastasis to sites containing TF-Ag-bin
Externí odkaz:
https://doaj.org/article/981ab7e7543342448ad99e400f15b989
Autor:
Jamie Heimburg, Jun Yan, Susan Morey, Olga V. Glinskii, Virginia H. Huxley, Linda Wild, Robert Klick, Rene Roy, Vladislav V. Glinsky, Kate Rittenhouse-Olson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 11, Pp 939-948 (2006)
Thomsen-Friedenreich antigen (TF-Ag) is expressed in many carcinomas, including those of the breast, colon, bladder, prostate. TF-Ag is important in adhesion and metastasis and as a potential immunotherapy target. We hypothesized that passive transfe
Externí odkaz:
https://doaj.org/article/131fa5370633449f8160e88a7c91b15d