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pro vyhledávání: '"Jamie H Cate"'
Autor:
Mia C Pulos-Holmes, Daniel N Srole, Maria G Juarez, Amy S-Y Lee, David T McSwiggen, Nicholas T Ingolia, Jamie H Cate
Publikováno v:
eLife, Vol 8 (2019)
A central problem in human biology remains the discovery of causal molecular links between mutations identified in genome-wide association studies (GWAS) and their corresponding disease traits. This challenge is magnified for variants residing in non
Externí odkaz:
https://doaj.org/article/274dded8bd894ce6aaf2d9c17728ce3f
Autor:
Aaron S. Mendez, Michael Ly, Angélica M. González-Sánchez, Ella Hartenian, Nicholas T. Ingolia, Jamie H. Cate, Britt A. Glaunsinger
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109841- (2021)
Summary: Nonstructural protein 1 (nsp1) is a coronavirus (CoV) virulence factor that restricts cellular gene expression by inhibiting translation through blocking the mRNA entry channel of the 40S ribosomal subunit and by promoting mRNA degradation.
Externí odkaz:
https://doaj.org/article/3bdf0a9c725548428be160cdb0a5bfb9