Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jamie Giddings"'
Autor:
Inn H. Yuk, Theo Koulis, Nidhi Doshi, Kathrin Gregoritza, Constanze Hediger, Vanessa Lebouc-Haefliger, Jamie Giddings, Tarik A. Khan
Publikováno v:
AAPS Open, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Hydrolytic degradation of the polysorbate 20 (PS20) surfactant in protein-based liquid formulations releases free fatty acids (FFAs), which can accumulate to form particles in drug products during real-time (long-term) storage. To identify f
Externí odkaz:
https://doaj.org/article/309e1482153a44eda5ca7dc1603040aa
Autor:
Aadithya Kannan, Jamie Giddings, Shrenik Mehta, Tiffany Lin, Anthony Tomlinson, Kyle Ritchie, Ian Shieh, Miguel Saggu, Nidhi Doshi
Publikováno v:
Pharmaceutical Research. 39:563-575
Polysorbates (PS) contain polyoxyethylene (POE) sorbitan/isosorbide fatty acid esters that can partially hydrolyze over time in liquid drug products to generate degradants and a remaining intact PS fraction with a modified ester distribution. The deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6321cd3827aa74bb2b52b436d4bca7a
https://doi.org/10.1007/s11095-022-03217-x
https://doi.org/10.1007/s11095-022-03217-x
Autor:
Steve Russell, Wenqiang Liu, Aadithya Kannan, Tamanna Shobha, Kyle Ritchie, Anthony Tomlinson, Miguel Saggu, Stephen Rumbelow, Jamie Giddings, Rosalynn Taing, Kathrin Gregoritza, Nidhi Doshi, Sandeep Yadav, Victor Nicoulin, Jeff Chu, Si Kai Cai, Lin Luis
Publikováno v:
Pharmaceutical research. 38(9)
To evaluate a modified high purity polysorbate 20 (RO HP PS20)—with lower levels of stearate, palmitate and myristate esters than the non-modified HP PS20—as a surfactant in biopharmaceutical drug products (DP). RO HP PS20 was designed to provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a21df0590584752abfffc3de701c783
https://pubmed.ncbi.nlm.nih.gov/34495486
https://pubmed.ncbi.nlm.nih.gov/34495486
Autor:
Aadithya Kannan, Ian C. Shieh, Alavattam Sreedhara, Tobias Graf, Arthur Wu, Kyle Ritchie, Mark Hu, Rosalynn Taing, Wayman Chan, Nidhi Doshi, Lin Luis, Pervina Kei, Wenqiang Liu, Jeff Chu, Jamie Giddings
Publikováno v:
Pharmaceutical research. 38(3)
Enzymatic polysorbate (PS) degradation and resulting free fatty acid (FFA) particles are detrimental to biopharmaceutical drug product (DP) stability. Different types and grades of polysorbate have varying propensity to form FFA particles. This work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4df16a66086fa1c438897714437e30
https://pubmed.ncbi.nlm.nih.gov/33713012
https://pubmed.ncbi.nlm.nih.gov/33713012