Výsledky vyhledávání - "Jamie Eisner"

Ca2+-induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy

Autor: Betty Belknap, Gunnar F. Schröder, Howard D. White, Jamie Eisner, David H. Heeley, Cristina Risi, Vitold E. Galkin

Muscle contraction relies on the interaction of myosin motors with F-actin, which is regulated through a translocation of tropomyosin by the troponin complex in response to Ca2+. The current model of muscle regulation holds that at relaxing (low-Ca2+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61a7cef9103bf9121c09e04e3f8944e
https://europepmc.org/articles/PMC5495243/

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C0 Domain of Cardiac Myosin Binding Protein-C Modulates Interaction of the Neighboring C1 Domain with Tropomyosin Through the Allosteric Interaction with F-Actin

Autor: Cristina Risi, Jamie Eisner, Samantha P. Harris, Betty Virok, Julio A. Kovacs, Howard D. White, Vitold E. Galkin, Willy Wriggers

Publikováno v: Biophysical Journal. 112:561a

Mutations in cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy affecting millions of people worldwide. Recent studies established that the N-terminal domains (NTDs) of cMyBP-C (e.g., C0, C1, M, and C2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e8a75f5f171b136a4c7dac576751efa
https://doi.org/10.1016/j.bpj.2016.11.3023

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Abstract 3498: Increased cellular stress and apoptosis induced by anti-SIAH2 therapy in human cancer cells with oncogenic K-RAS addiction

Autor: Amy H. Tang, Jamie Eisner, Monicah M. Njogu, Robert Vansciver, Caroline Dasom Lee, Minglei Bian

Publikováno v: Cancer Research. 76:3498-3498

Hyperactivated K-RAS oncoproteins are known to drive cell proliferation, tumor growth, and metastasis. Oncogene addiction is often associated with increased ER and mitochondrial stress due to excessive reactive oxygen and nitrogen species (ROS & NROS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d24e0f81412bfe431f24c2f05661d99
https://doi.org/10.1158/1538-7445.am2016-3498

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Abstract 2008: Proteomic analysis of SIAH2 E3 ligase complex in oncogenic K-Ras-driven cell transformation in human cancer

Autor: Jamie Eisner, Monicah M. Njogu, Ming Lei Bian, Amy H. Tang

Publikováno v: Cancer Research. 75:2008-2008

Affinity purification-mass spectrometry (AP-MS) is a highly effective method of identifying and quantifying the individual constituents of molecular machines that are dynamically regulated by diverse cellular stimuli during tumor initiation, progress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9652a0a2a793755bd35915953f707e70
https://doi.org/10.1158/1538-7445.am2015-2008

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