Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jamie E. Moscovitz"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79841 (2013)
The purpose of this study was to determine whether Nrf2 activation, via Keap1-knockdown (Keap1-KD), regulates lipid metabolism and mobilization induced by food deprivation (e.g. fasting).Male C57BL/6 (WT) and Keap1-KD mice were either fed ad libitum
Externí odkaz:
https://doaj.org/article/10f553a2fe6145878879302b9e7a16ab
Autor:
Barry Weinberger, Laura Saba, Poi Yu Sofia Yuen, Lauren M. Aleksunes, Jamie E. Moscovitz, Naureen Memon, Xia Wen, Kristin M. Bircsak, Faith E. Archer, Anna M. Vetrano, Moiz Mohammed
Publikováno v:
Drug Metabolism and Disposition. 46:619-627
The breast cancer resistance protein (BCRP/ABCG2) is a maternally-facing efflux transporter that regulates the placental disposition of chemicals. Transcription factors and gene variants are important regulatory factors that influence transporter exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612237af939b66d740216426c21a20ec
https://doi.org/10.1124/dmd.117.079228
https://doi.org/10.1124/dmd.117.079228
Publikováno v:
Expert Opinion on Therapeutic Patents. 28:111-122
Diabetes is a metabolic disease characterized by elevated levels of plasma glucose. When untreated, diabetes increases the risk of developing co-morbidities such as cardiovascular disease. Several drugs, often used as part of combination therapies, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bae2f90d3238cb3cf74703cbf3a28e2
https://doi.org/10.1080/13543776.2018.1406477
https://doi.org/10.1080/13543776.2018.1406477
Publikováno v:
Toxicology and Applied Pharmacology. 310:60-67
The farnesoid X receptor (Fxr) controls bile acid homeostasis by coordinately regulating the expression of synthesizing enzymes (Cyp7a1, Cyp8b1), conjugating enzymes (Bal, Baat) and transporters in the ileum (Asbt, Ostα/β) and liver (Ntcp, Bsep, Os
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae783c2bacc4bd1c8a2a43ec732d7e8
https://doi.org/10.1016/j.taap.2016.08.021
https://doi.org/10.1016/j.taap.2016.08.021
Autor:
Theunis C. Goosen, Nathaniel Johnson, Jamie E. Moscovitz, Yan Weng, Amit S. Kalgutkar, Kelly Nulick, Zhiwu Lin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 365(2)
The potential for drug-drug interactions (DDIs) arising from transcriptional regulation of drug-disposition genes via activation of nuclear receptors (NRs), such as pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb442648f3ea090293e4382a000adfb0
https://pubmed.ncbi.nlm.nih.gov/29440451
https://pubmed.ncbi.nlm.nih.gov/29440451
Autor:
Jamie E. Moscovitz, Nathaniel Johnson, Meihua Tu, Yan Weng, Theunis C. Goosen, Amit S. Kalgutkar, Zhiwu Lin
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(7)
1. 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl) acetamide (PF-06282999) is a member of the thiouracil class of irreversible inactivators of human myeloperoxidase enzyme and a candidate for the treatment of cardiovascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f553c197eb41d019356cd764379b9e38
https://pubmed.ncbi.nlm.nih.gov/28685622
https://pubmed.ncbi.nlm.nih.gov/28685622
Autor:
Lauren M. Aleksunes, Jamie E. Moscovitz, Guadalupe Herrera-Garcia, Grace L. Guo, Gabriel Yarmush
1. In the intestines, the nuclear receptors farnesoid X receptor (Fxr) and pregnane X receptor (Pxr) regulate the transcription of metabolizing enzymes and transporters that dictate the absorption of nutrients and xenobiotics. 2. Here, we sought to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3dcba600cbfe41905439082fa63e92
This chapter provides an overview of the physiologic and pharmacokinetic changes that influence drug disposition during pregnancy. The dynamic regulation of hepatic phases I and II metabolic enzymes as well as transporters in pregnant animals and wom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9c02eb90e465aded6387a5218991db2
https://doi.org/10.1016/b978-0-12-802949-7.00009-2
https://doi.org/10.1016/b978-0-12-802949-7.00009-2
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 12, Pp 23801-23827 (2013)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The ultimate fate of drugs and chemicals in the body is largely regulated by hepatic uptake, metabolism, and excretion. The liver acquires the functional ability to metabolize and transport chemicals during the perinatal period of development. Resear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6561a33ab30c5b60040ff6612b9358
http://www.mdpi.com/1422-0067/14/12/23801
http://www.mdpi.com/1422-0067/14/12/23801
Autor:
Jamie E. Moscovitz, Guadalupe Herrera-Garcia, Lauren M. Aleksunes, Amanda S. Bright, Dahea You, Grace L. Guo
Publikováno v:
Nuclear Receptor Research, Vol 3, Pp 1-10 (2016)
More than half of pregnant women use prescription medications in order to maintain both maternal and fetal health. The constitutive androstane receptor (Car) critically affects the disposition of chemicals by regulating the transcription of genes enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b896ebceb4e45291987209fea44da1d1
https://pubmed.ncbi.nlm.nih.gov/27818994
https://pubmed.ncbi.nlm.nih.gov/27818994