Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Jamie E. Kugler"'
1
Akademický článek
Xbp1 and Brachyury establish an evolutionarily conserved subcircuit of the notochord gene regulatory network
Autor: Yushi Wu, Arun Devotta, Diana S José-Edwards, Jamie E Kugler, Lenny J Negrón-Piñeiro, Karina Braslavskaya, Jermyn Addy, Jean-Pierre Saint-Jeannet, Anna Di Gregorio
Publikováno v: eLife, Vol 11 (2022)
Gene regulatory networks coordinate the formation of organs and structures that compose the evolving body plans of different organisms. We are using a simple chordate model, the Ciona embryo, to investigate the essential gene regulatory network that
Externí odkaz: https://doaj.org/article/1ff7990aa16547bfb607968faf7ce345
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3
Akademický článek
Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord.
Autor: Diana S José-Edwards, Izumi Oda-Ishii, Jamie E Kugler, Yale J Passamaneck, Lavanya Katikala, Yutaka Nibu, Anna Di Gregorio
Publikováno v: PLoS Genetics, Vol 11, Iss 12, p e1005730 (2015)
A main challenge of modern biology is to understand how specific constellations of genes are activated to differentiate cells and give rise to distinct tissues. This study focuses on elucidating how gene expression is initiated in the notochord, an a
Externí odkaz: https://doaj.org/article/382ba432965a4af58278519574818c82
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4
Xbp1 and Brachyury establish an evolutionarily conserved subcircuit of the notochord gene regulatory network
Autor: Yushi Wu, Arun Devotta, Diana S José-Edwards, Jamie E Kugler, Lenny J Negrón-Piñeiro, Karina Braslavskaya, Jermyn Addy, Jean-Pierre Saint-Jeannet, Anna Di Gregorio
Publikováno v: eLife
eLife, Vol 11 (2022)
Gene regulatory networks coordinate the formation of organs and structures that compose the evolving body plans of different organisms. We are using a simple chordate model, the Ciona embryo, to investigate the essential gene regulatory network that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd610850a6c8d4147e4a10ad51a945c3
https://pubmed.ncbi.nlm.nih.gov/35049502
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5
Akademický článek
Functional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochord.
Autor: Lavanya Katikala, Hitoshi Aihara, Yale J Passamaneck, Stefan Gazdoiu, Diana S José-Edwards, Jamie E Kugler, Izumi Oda-Ishii, Janice H Imai, Yutaka Nibu, Anna Di Gregorio
Publikováno v: PLoS Biology, Vol 11, Iss 10, p e1001697 (2013)
The appearance of the notochord represented a milestone in Deuterostome evolution. The notochord is necessary for the development of the chordate body plan and for the formation of the vertebral column and numerous organs. It is known that the transc
Externí odkaz: https://doaj.org/article/3afe01d8c72f49d2b75bc32adec0d804
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6
Positioning a multifunctional basic helix-loop-helix transcription factor within the Ciona notochord gene regulatory network
Autor: Jamie E. Kugler, Jermyn Addy, Raymond Li, Natalia Caballero, Yushi Wu, Anna Di Gregorio, Yale J. Passamaneck, Izumi Oda-Ishii, Lavanya Katikala, Julie E. Maguire
In a multitude of organisms, transcription factors of the basic helix-loop-helix (bHLH) family control the expression of genes required for organ development and tissue differentiation. The functions of different bHLH transcription factors in the spe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f99185c9384b434ac6bc3b787254a3
https://europepmc.org/articles/PMC6788811/
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8
Elevated HMGN4 expression potentiates thyroid tumorigenesis
Autor: Jamie E. Kugler, Yuri V. Postnikov, Takashi Furusawa, Michael Bustin, Shioko Kimura
Publikováno v: Carcinogenesis. 38(4)
Thyroid cancer originates from genetic and epigenetic changes that alter gene expression and cellular signaling pathways. Here, we report that altered expression of the nucleosome-binding protein HMGN4 potentiates thyroid tumorigenesis. Bioinformatic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa937b8c40ba5418e92f5004e942817
https://pubmed.ncbi.nlm.nih.gov/28186538
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9
The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network
Autor: Pierre Kerner, Di Jiang, Jamie E. Kugler, Diana S. José-Edwards, Wei Deng, Anna Di Gregorio
Publikováno v: Developmental Dynamics. 240:1793-1805
The notochord is the distinctive characteristic of chordates; however, the knowledge of the complement of transcription factors governing the development of this structure is still incomplete. Here we present the expression patterns of seven transcri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4675f1a9501bf5cc40f2051575dd147e
https://doi.org/10.1002/dvdy.22656
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10
Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome
Autor: Jamie E. Kugler, Stefania Asciutti, Licia Selleri, Anna Di Gregorio, Rediet Zewdu, Giuseppina Di Giacomo, Terence D. Capellini
Publikováno v: Developmental Biology. 321(2):500-514
The post-cranial axial skeleton consists of a metameric series of vertebral bodies and intervertebral discs, as well as adjoining ribs and sternum. Patterning of individual vertebrae and distinct regions of the vertebral column is accomplished by Pol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d27cd1f3406fed1a70a27336645d34
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