Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jamie D. Knight"'
Autor:
Emily J. Hanan, Marie-Gabrielle Braun, Robert A. Heald, Calum MacLeod, Connie Chan, Saundra Clausen, Kyle A. Edgar, Charles Eigenbrot, Richard Elliott, Nicholas Endres, Lori S. Friedman, Emily Gogol, Xiao-Hui Gu, Rebecca Hong Thibodeau, Philip S. Jackson, James R. Kiefer, Jamie D. Knight, Michelle Nannini, Raman Narukulla, Amanda Pace, Jodie Pang, Hans E. Purkey, Laurent Salphati, Deepak Sampath, Stephen Schmidt, Steve Sideris, Kyung Song, Swathi Sujatha-Bhaskar, Mark Ultsch, Heidi Wallweber, Jianfeng Xin, SiewKuen Yeap, Amy Young, Yu Zhong, Steven T. Staben
Publikováno v:
Journal of medicinal chemistry. 65(24)
Small molecule inhibitors that target the phosphatidylinositol 3-kinase (PI3K) signaling pathway have received significant interest for the treatment of cancers. The class I isoform PI3Kα is most commonly associated with solid tumors via gene amplif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085a38e6723d04c169025fcfa48abbbc
https://pubmed.ncbi.nlm.nih.gov/36455032
https://pubmed.ncbi.nlm.nih.gov/36455032
Autor:
Charles Eigenbrot, Robert Heald, Bryan K. Chan, Michael D. Lainchbury, Timothy P. Heffron, Hans E. Purkey, Hank La, Philip Stephen Jackson, Stephen P. Schmidt, Gabriele Schaefer, Emily Chan, Marian C. Bryan, Ivana Yen, Jamie D. Knight, Daniel J. Burdick, Yuan Chen, Lily Shao, Richard L. Elliott, Jennafer Dotson, Shiva Malek, Christine Yu, Krista K. Bowman, Steve Sideris, Hanan Emily, Shumei Wang, Saundra Clausen, Siew Kuen Yeap, Eileen Mary Seward, Trisha Dela Vega
Publikováno v:
Journal of medicinal chemistry. 59(19)
Inhibitors targeting the activating mutants of the epidermal growth factor receptor (EGFR) have found success in the treatment of EGFR mutant positive non-small-cell lung cancer. A secondary point mutation (T790M) in the inhibitor binding site has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4580624912774874fa97c4be36fcef
https://pubmed.ncbi.nlm.nih.gov/27564586
https://pubmed.ncbi.nlm.nih.gov/27564586
Autor:
Krista K. Bowman, Hans E. Purkey, Bryan K. Chan, Michael D. Lainchbury, Belen Dominguez-Fernandez, Robert Heald, Eileen Mary Seward, Stephen P. Schmidt, Mark Merchant, Lily Shao, Kuen Yeap, Saundra Clausen, Emily Chan, Daniel J. Burdick, Yuan Chen, Charles Eigenbrot, Gabriele Schaefer, Steve Sideris, Philip Stephen Jackson, Samuel Edward Mann, Ivana Yen, Richard L. Elliott, Kyle Mortara, Timothy P. Heffron, Hank La, Marian C. Bryan, Christine Yu, Shiva Malek, Jamie D. Knight, Hanan Emily, Shumei Wang
Publikováno v:
Journal of medicinal chemistry. 58(22)
Because of their increased activity against activating mutants, first-generation epidermal growth factor receptor (EGFR) kinase inhibitors have had remarkable success in treating non-small-cell lung cancer (NSCLC) patients, but acquired resistance, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35671f7efc64173278adb957d251e6f
https://pubmed.ncbi.nlm.nih.gov/26967667
https://pubmed.ncbi.nlm.nih.gov/26967667
Publikováno v:
Organic Letters. 7:713-716
Electrophilic amination of primary aliphatic and aromatic amines is reported using a diethylketomalonate-derived oxaziridine to afford the corresponding N-Boc hydrazines in good to excellent yields. The method allows a one-pot synthesis of pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d4d43a444448b1a29e2c9b4b0e5060
https://doi.org/10.1021/ol0474507
https://doi.org/10.1021/ol0474507
Autor:
Matthew Rudd, Paul Wright, Matthew J. Tozer, Jonathan W. Steed, S. Barret Kalindjian, Susan E. Gibson, Jerome O. Jones, Nello Mainolfi, Jamie D. Knight
Publikováno v:
Tetrahedron. 60:6945-6958
[7.7], [8.8], [9.9] and [13.13] Paracyclophanes and [9.9] and [13.13] metacyclophanes containing two unsaturated amino acid residues have been synthesised. An X-ray crystallographic study of three of the paracyclophanes and molecular modelling of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b063488ba8531c13f6457fc0d72cec
https://doi.org/10.1016/j.tet.2004.05.062
https://doi.org/10.1016/j.tet.2004.05.062
Publikováno v:
Tetrahedron Letters. 43:6991-6994
( S )-3-Amino-4-[(1 H )imidazol-4-yl]butanoic acid ( 1 ), a β-amino acid which is a homologue of l -histidine, has been synthesised in five steps from l -histidine methyl ester. The presence of N (α)- and N (Im)-2,4,6-trimethylbenzenesulfonyl prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87128239ef59a43066c4951044d0317
https://doi.org/10.1016/s0040-4039(02)01587-3
https://doi.org/10.1016/s0040-4039(02)01587-3
Autor:
Richard S. Cooke, Alan Armstrong, Graham R. Cumming, Jamie D. Knight, Ian D. Edmonds, Stephen E. Shanahan
Publikováno v:
Chinese Journal of Chemistry. 23:1270-1272
Structure/reactivity relationships of N-alkoxycarbonyl- and N-carboxamidooxaziridines are explored, and conditions are discovered for the efficient amination of sulfides and primary amines. Reactions of these oxaziridines with alkenes are also examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1022565f03bbdcc270267add126289d4
https://doi.org/10.1002/cjoc.200591270
https://doi.org/10.1002/cjoc.200591270
Autor:
Lily Shao, Gabriele Schaefer, Belen Dominguez-Fernandez, Krista K. Bowman, Robert Heald, Jamie D. Knight, Timothy P. Heffron, Christine Yu, Mark Merchant, Stephen P. Schmidt, Kuen Yeap, Kyle Mortara, Charles Eigenbrot, Hank La, Michael Lainchbury, Ivana Yen, Daniel J. Burdick, Eileen Mary Seward, Yuan Chen, Saundra Clausen, Bryan K. Chan, Shiva Malek, Richard L. Elliott, Hanan Emily, Shumei Wang, Hans E. Purkey, Philip Stephen Jackson, Marian C. Bryan, Emily Chan, Samuel Edward Mann, Steve Sideris
Publikováno v:
Journal of Medicinal Chemistry. 59:2848-2848
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c972dae98703003aebe8beae61e894
https://doi.org/10.1021/acs.jmedchem.6b00301
https://doi.org/10.1021/acs.jmedchem.6b00301
Autor:
Jerome O. Jones, Jamie D. Knight, Susan E. Gibson, Matthew J. Tozer, Jonathan W. Steed, S. Barret Kalindjian
Publikováno v:
ChemInform. 33
The syntheses and structures of three cyclophanes containing two (Z)-dehydrophenylalanine residues are reported; the length of the tethers between the two amino acid residues is easily altered and changing this parameter has a significant effect on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a62be1870dd3ea889f877b84d181c2f7
https://doi.org/10.1002/chin.200251082
https://doi.org/10.1002/chin.200251082
Autor:
Alan Armstrong, Jamie D. Knight
Publikováno v:
ChemInform. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152dbfbfa09a55c7abd193010404289f
https://doi.org/10.1002/chin.200521245
https://doi.org/10.1002/chin.200521245