Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jamie Boulet"'
Autor:
Brian C. Shook, Kenneth C. Rupert, Stefanie Rassnick, Hall Daniel A, Scott Davis, Sandra Damon, Reyes Mayra B, Lori Westover, Melville C. Osborne, Scott Youells, Yuting Tang, Ronald K. Russell, Keith T. Demarest, Xun Li, Paul F. Jackson, Shawn Branum, Devraj Chakravarty, Derek A. Beauchamp, Kristin Hansen, Kenneth J. Rhodes, David C. Palmer, James L. Bullington, Geoffrey R. Heintzelman, Kenneth M. Wells, Jamie Boulet
Publikováno v:
Journal of Medicinal Chemistry. 53:8104-8115
The in vivo characterization of a dual adenosine A(2A)/A(1) receptor antagonist in several animal models of Parkinson's disease is described. Discovery and scale-up syntheses of compound 1 are described in detail, highlighting optimization steps that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a3abc6b1bb2388ce859a84328d2aeb
https://doi.org/10.1021/jm100971t
https://doi.org/10.1021/jm100971t
Autor:
Martin Coupal, Paul Jones, Lejla Hodzic, Wenhau Xiao, Edward Roberts, Andrew Griffin, Daniel Delorme, Dominic Salois, Maryse Labarre, Stephane St-Onge, Christopher Walpole, Jamie Boulet, Lars Gawell, Rico Lavoie, Joanne Butterworth, William Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5994-5998
We have investigated a series of phenolic diaryl amino piperidine delta opioid receptor agonists, establishing the importance of the phenol functional group and substitution on the piperdine nitrogen for delta agonist activity and selectivity versus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309cc40e144f4ea22f0ebf8874c89c2d
https://doi.org/10.1016/j.bmcl.2009.09.072
https://doi.org/10.1016/j.bmcl.2009.09.072
Publikováno v:
Biomedical Chromatography. 23:973-979
A simple and sensitive analytical method using liquid chromatography-tandem mass spectrometry (LC/MS/MS) for determination of acetylsalicylic acid (aspirin, ASA) and its major metabolite, salicylic acid (SA), in animal plasma has been developed and v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc069550a20831451ad502b9df17315
https://doi.org/10.1002/bmc.1209
https://doi.org/10.1002/bmc.1209
Autor:
Jamie Boulet, Harry Maselli, Bryan Strenkowski, Garth Whiteside, Jessica D. Beyenhof, Michele Hummel, Terri Knappenberger, Janet Dell John, Lee Koetzner
Publikováno v:
Journal of pharmacological and toxicological methods. 78
Whole body plethysmography using unrestrained animals is a common technique for assessing the respiratory risk of new drugs in safety pharmacology studies in rats. However, wide variations in experimental technique make cross laboratory comparison of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47138510eb0cd541b263bcbd203a8d37
https://pubmed.ncbi.nlm.nih.gov/26589431
https://pubmed.ncbi.nlm.nih.gov/26589431
Autor:
James E. Harrison, Garth Whiteside, Michelle S. Pearson, Jamie Boulet, Susan L. Gottshall, Katharine Walker, Lilly Mark
Publikováno v:
British Journal of Pharmacology. 141:85-91
1. Both clinical and preclinical models of postsurgical pain are being used more frequently in the early evaluation of new chemical entities. In order to assess the validity and reliability of a rat model of postincisional pain, the effects of differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fb3990ebb87f723f2a8d040da8a6c51
https://doi.org/10.1038/sj.bjp.0705568
https://doi.org/10.1038/sj.bjp.0705568
Publikováno v:
Digestive Diseases and Sciences
Several plant-derived polysaccharides have been shown to have anti-inflammatory activity in animal models. Ambrotose complex and Advanced Ambrotose are dietary supplements that include aloe vera gel, arabinogalactan, fucoidan, and rice starch, all of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19076b96b761c6b8f29a50d37216f09
https://pubmed.ncbi.nlm.nih.gov/19513840
https://pubmed.ncbi.nlm.nih.gov/19513840
Autor:
Peter Barbounis, Gao Dong, Thomas S. Scanlan, Jamie Boulet, Celeste Dunn, Ngoc Ha Nguyen, Jason Domogauer, Gary J. Grover
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 322(1)
NH3 is a thyroid hormone receptor (TR) antagonist that inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment. It was active in a tadpole tail resorption assay, with partial agonist activity at high concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2399d4b90195701cfbc5a16362ddbb64
https://pubmed.ncbi.nlm.nih.gov/17440037
https://pubmed.ncbi.nlm.nih.gov/17440037
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 314(3)
The role of opioid receptors located in the central nervous system (CNS) and peripheral nervous system in inflammatory pain is well established. In contrast, although it is has been shown that mu agonists can reduce other manifestations of inflammati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66653fe9e75922228acfb3bc0c870901
https://pubmed.ncbi.nlm.nih.gov/15937151
https://pubmed.ncbi.nlm.nih.gov/15937151
Autor:
Jamie Boulet, Susan L. Gottshall, Kenneth J. Valenzano, Michelle S. Pearson, Paul I. Turchin, Garth Whiteside, Lilly Mark, Suzanne M. Chaffer, Augusta E. Garrison, James E. Harrison
Publikováno v:
European journal of pharmacology. 528(1-3)
Several recent reports have demonstrated a role for selective cannabinoid CB2 receptor agonists in pain modulation, showing both analgesic and antihyperalgesic activities. While the mechanism of action is poorly understood, it has been postulated tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e846dc3b34cf714050413c2f8708282
https://pubmed.ncbi.nlm.nih.gov/16316650
https://pubmed.ncbi.nlm.nih.gov/16316650
Publikováno v:
Bone. 38(3)
Changes in bone mineral density (BMD) are associated with clinical neuropathies. Following nerve injury in the rat, there is a loss of BMD, which may be related to nerve injury or reduced mechanical loading. The purpose of this study was to investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c60a6667ee98f8f87f9509bbffe38f4
https://pubmed.ncbi.nlm.nih.gov/16203196
https://pubmed.ncbi.nlm.nih.gov/16203196