Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jamie B. Littleboy"'
Autor:
Man-Tat Lau, Shila Ghazanfar, Ashleigh Parkin, Angela Chou, Jourdin R. Rouaen, Jamie B. Littleboy, Danielle Nessem, Thang M. Khuong, Damien Nevoltris, Peter Schofield, David Langley, Daniel Christ, Jean Yang, Marina Pajic, G. Gregory Neely
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs. Results In ad
Externí odkaz:
https://doaj.org/article/c47471a679ca416996391ad2844c7411
Autor:
Man-Tat Lau, John Manion, Jamie B. Littleboy, Lisa Oyston, Thang M. Khuong, Qiao-Ping Wang, David T. Nguyen, Daniel Hesselson, Jamie E. Seymour, G. Gregory Neely
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Box jellyfish venom causes tissue damage, pain, and death through unknown molecular mechanisms. Here, Lau et al. perform a CRISPR screen to identify genes required for venom action and use this information to develop an antidote that blocks venom-ind
Externí odkaz:
https://doaj.org/article/7783b05d2b904dac8b8436b3b11b2579
Autor:
Peter R. Schofield, Man-Tat Lau, Jean Yang, David B. Langley, Thang M. Khuong, Danielle Nessem, Marina Pajic, Daniel Christ, Angela Chou, Jourdin R. Rouaen, Jamie B. Littleboy, Damien Nevoltris, Shila Ghazanfar, G. Gregory Neely, Ashleigh Parkin
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-12 (2020)
Genome Biology
Genome Biology
Background Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs. Results In addition to
Autor:
Leslie Caron, Lipin Loo, Mark Larance, Michael Costigan, G. Gregory Neely, John Manion, Thang M. Khuong, Jamie B. Littleboy, Dylan J. Harney, Travis Ruan
Publikováno v:
Pain. 161(2)
Neuropathic pain causes severe suffering, and most patients are resistant to current therapies. A core element of neuropathic pain is the loss of inhibitory tone in the spinal cord. Previous studies have shown that foetal GABAergic neuron precursors
Autor:
Thang M. Khuong, Man-Tat Lau, John Manion, Daniel Hesselson, G. Gregory Neely, Lisa J. Oyston, Qiao-Ping Wang, Jamie Seymour, Jamie B. Littleboy, David T. Nguyen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The box jellyfish Chironex fleckeri is extremely venomous, and envenoming causes tissue necrosis, extreme pain and death within minutes after severe exposure. Despite rapid and potent venom action, basic mechanistic insight is lacking. Here we perfor