Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jamie A. Saxon"'
Autor:
Allyson G. McLoed, Taylor P. Sherrill, Dong-Sheng Cheng, Wei Han, Jamie A. Saxon, Linda A. Gleaves, Pingsheng Wu, Vasiliy V. Polosukhin, Michael Karin, Fiona E. Yull, Georgios T. Stathopoulos, Vassilis Georgoulias, Rinat Zaynagetdinov, Timothy S. Blackwell
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 120-132 (2016)
Although epithelial NF-κB signaling is important for lung carcinogenesis, NF-κB inhibitors are ineffective for cancer treatment. To explain this paradox, we studied mice with genetic deletion of IKKβ in myeloid cells and found enhanced tumorigenes
Externí odkaz:
https://doaj.org/article/f58ff440a1344da388aafc8cddd5f332
Autor:
Timothy S. Blackwell, Georgios T. Stathopoulos, Fiona E. Yull, Barbara Fingleton, R. Stokes Peebles, Daniel Dulek, Linda Connelly, Arun C. Habermann, Jamie A. Saxon, Allyson G. McLoed, Linda A. Gleaves, Taylor P. Sherrill, Rinat Zaynagetdinov
Figure S2. Deficiency in IL-5 does not affect infiltration of lungs with T and B lymphocytes and NK cells during initial stages of metastatic load of LLC cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f629ace44083a1b9a05698a550cda3b
https://doi.org/10.1158/0008-5472.22407179.v1
https://doi.org/10.1158/0008-5472.22407179.v1
Autor:
Jamie A. Saxon, Michael J. Eck, Pasi A. Jänne, T. Kosaka, Jieun Son, Eun Young Park, Hwan Geun Choi, Nathanael S. Gray, Dries De Clercq, Jaebong Jang, Junko Tanizaki
Publikováno v:
Angewandte Chemie International Edition. 57:11629-11633
Exon 20 insertion (Ex20Ins) mutations are the third most prevalent epidermal growth factor receptor (EGFR) activating mutation and the most prevalent HER2 mutation in non-small cell lung cancer (NSCLC). Novel therapeutics for the patients with Ex20In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3ca283f176fc641031ad1bf71f26c2
https://doi.org/10.1002/anie.201805187
https://doi.org/10.1002/anie.201805187
Autor:
Jamie A. Saxon, Wei Han, Taylor P. Sherrill, Harikrishna Tanjore, Allyson G. McLoed, Fiona E. Yull, Timothy S. Blackwell, Linda A. Gleaves, Vasiliy V. Polosukhin, Bradley W. Richmond, Dong-Sheng Cheng, Whitney Barham
Publikováno v:
The Journal of Immunology. 196:1891-1899
Although numerous studies have demonstrated a critical role for canonical NF-κB signaling in inflammation and disease, the function of the noncanonical NF-κB pathway remains ill-defined. In lung tissue from patients with acute respiratory distress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e467ec3d659b8949fa0fbc64cdc9d769
https://doi.org/10.4049/jimmunol.1501555
https://doi.org/10.4049/jimmunol.1501555
Autor:
Timothy S. Blackwell, Allyson G. McLoed, Wei Han, Rinat Zaynagetdinov, Linda A. Gleaves, Lisa R. Young, Peter M. Gulleman, Jamie A. Saxon, Taylor P. Sherrill, Pierre Hunt, Harikrishna Tanjore
Publikováno v:
Oncotarget
// Rinat Zaynagetdinov 1 , Taylor P. Sherrill 1 , Linda A. Gleaves 1 , Pierre Hunt 1 , Wei Han 1 , Allyson G. McLoed 2 , Jamie A. Saxon 2 , Harikrishna Tanjore 1 , Peter M. Gulleman 4 , Lisa R. Young 1, 4 , Timothy S. Blackwell 1, 2, 3 1 Department o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0134b701ce6434c4eeaa725fe8a14d3f
http://europepmc.org/articles/PMC4868699
http://europepmc.org/articles/PMC4868699
Autor:
Fiona E. Yull, Zhongming Zhao, Allyson G. McLoed, Linda A. Gleaves, Timothy S. Blackwell, Jamie A. Saxon, Vasiliy V. Polosukhin, Hui Yu, Georgios T. Stathopoulos, Pierre P. Massion
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Sci. Rep. 8:6078 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Sci. Rep. 8:6078 (2018)
While many studies have demonstrated that canonical NF-κB signaling is a central pathway in lung tumorigenesis, the role of non-canonical NF-κB signaling in lung cancer remains undefined. We observed frequent nuclear accumulation of the non-canonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca0a5a4babf0ce4375fce5b11f6acf7
https://doi.org/10.1038/s41598-018-24488-8
https://doi.org/10.1038/s41598-018-24488-8
Autor:
Linda A. Gleaves, Barbara Fingleton, R. Stokes Peebles, Georgios T. Stathopoulos, Daniel E. Dulek, Rinat Zaynagetdinov, Allyson G. McLoed, Arun C. Habermann, Timothy S. Blackwell, Fiona E. Yull, Jamie A. Saxon, Linda Connelly, Taylor P. Sherrill
Publikováno v:
Cancer Research. 75:1624-1634
Although the lung is the most common metastatic site for cancer cells, biologic mechanisms regulating lung metastasis are not fully understood. Using heterotopic and intravenous injection models of lung metastasis in mice, we found that IL5, a cytoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec8f19c115ac16ed6dfd2b30f7c4b04
https://doi.org/10.1158/0008-5472.can-14-2379
https://doi.org/10.1158/0008-5472.can-14-2379
Publikováno v:
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 12(5)
Introduction Tyrosine kinase inhibitors (TKIs) have been developed to treat patients with EGFR-mutant lung cancers. However, the therapeutic efficacy of TKIs in patients with uncommon EGFR mutations remains unclear. Methods Next-generation sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a770cba40ec0ba78c9f0f4e7a8a94c2
https://pubmed.ncbi.nlm.nih.gov/28939152
https://pubmed.ncbi.nlm.nih.gov/28939152
Autor:
Ann Richmond, Linda A. Gleaves, Jamie A. Saxon, Fiona E. Yull, Allyson G. McLoed, Jiqing Sai, Vasiliy V. Polosukhin, Timothy S. Blackwell, Whitney Barham, Rinat Zaynagetdinov, Raphael P. Hunt, Peter Gulleman, Lisa R. Young, Taylor P. Sherrill, Dong-Sheng Cheng
Publikováno v:
Oncoimmunology. 5(6)
Several studies have demonstrated that NF-κB activation is common in lung cancer; however, the mechanistic links between NF-κB signaling and tumorigenesis remain to be fully elucidated. We investigated the function of NF-κB signaling in epidermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb600768f66efc4e4458351a8bfaffe
https://pubmed.ncbi.nlm.nih.gov/27471643
https://pubmed.ncbi.nlm.nih.gov/27471643
Autor:
Michael Karin, Georgios T. Stathopoulos, Wei Han, Pingsheng Wu, Jamie A. Saxon, Timothy S. Blackwell, Rinat Zaynagetdinov, Vassilis Georgoulias, Dong-Sheng Cheng, Fiona E. Yull, Allyson G. McLoed, Linda A. Gleaves, Vasiliy V. Polosukhin, Taylor P. Sherrill
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 120-132 (2016)
Cell Rep. 16, 120-132 (2016)
Cell Rep. 16, 120-132 (2016)
Although epithelial NF-κB signaling is important for lung carcinogenesis, NF-κB inhibitors are ineffective for cancer treatment. To explain this paradox, we studied mice with genetic deletion of IKKβ in myeloid cells and found enhanced tumorigenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe95ecb5e73851634c2e7803b878afa1