Zobrazeno 1 - 10
of 629
pro vyhledávání: '"Jamie, Rossjohn"'
Autor:
Asolina Braun, Louise C. Rowntree, Ziyi Huang, Kirti Pandey, Nikolas Thuesen, Chen Li, Jan Petersen, Dene R. Littler, Shabana Raji, Thi H. O. Nguyen, Emma Jappe Lange, Gry Persson, Michael Schantz Klausen, Jens Kringelum, Shanzou Chung, Nathan P. Croft, Pouya Faridi, Rochelle Ayala, Jamie Rossjohn, Patricia T. Illing, Katherine E. Scull, Sri Ramarathinam, Nicole A. Mifsud, Katherine Kedzierska, Anders Bundgård Sørensen, Anthony W. Purcell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Most COVID-19 vaccines elicit immunity against the SARS-CoV-2 Spike protein. However, Spike protein mutations in emerging strains and immune evasion by the SARS-CoV-2 virus demonstrates the need to develop more broadly targeting vaccines. To
Externí odkaz:
https://doaj.org/article/c27b1262e5a94fbaa2a295000016cee8
Autor:
Tiing Jen Loh, Jia Jia Lim, Claerwen M. Jones, Hien Thy Dao, Mai T. Tran, Daniel G. Baker, Nicole L. La Gruta, Hugh H. Reid, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract CD4+ T cells recognising citrullinated self-epitopes presented by HLA-DRB1 bearing the shared susceptibility epitope (SE) are implicated in rheumatoid arthritis (RA). However, the underlying T cell receptor (TCR) determinants of epitope spec
Externí odkaz:
https://doaj.org/article/da55e0bd7eb74b1a926c2737875550c7
Autor:
Tejas Menon, Patricia T. Illing, Priyanka Chaurasia, Hayley A. McQuilten, Chloe Shepherd, Louise C. Rowntree, Jan Petersen, Dene R. Littler, Grace Khuu, Ziyi Huang, Lilith F. Allen, Steve Rockman, Jane Crowe, Katie L. Flanagan, Linda M. Wakim, Thi H. O. Nguyen, Nicole A. Mifsud, Jamie Rossjohn, Anthony W. Purcell, Carolien E. van de Sandt, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8+ T-cells provide broadly cross-reactive immunity and alleviate disease severity by recognizing conserved epitopes.
Externí odkaz:
https://doaj.org/article/55f2082f9bf14d4cafdaccd45caeb502
Autor:
Carolyn Samer, Hamish E.G. McWilliam, Brian P. McSharry, Thilaga Velusamy, James G. Burchfield, Richard J. Stanton, David C. Tscharke, Jamie Rossjohn, Jose A. Villadangos, Allison Abendroth, Barry Slobedman
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108801- (2024)
Summary: The major histocompatibility complex (MHC), Class-I-related (MR1) molecule presents microbiome-synthesized metabolites to Mucosal-associated invariant T (MAIT) cells, present at sites of herpes simplex virus (HSV) infection. During HSV type
Externí odkaz:
https://doaj.org/article/6e9ab8496a94412f99c1c5df7b46f8e0
Autor:
Tanja D de Gruijl, Roeland Lameris, Jamie Rossjohn, Myrthe Veth, David Lutje Hulsik, Adam Shahine, Bart Westerman, Dale I Godfrey, Patricia Brouwer, Hans J van der Vliet
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background CD1d is a monomorphic major histocompatibility complex class I-like molecule that presents lipid antigens to distinct T-cell subsets and can be expressed by various malignancies. Antibody-mediated targeting of CD1d on multiple myeloma cell
Externí odkaz:
https://doaj.org/article/44eecee2a3e44705a7cd0649a4af661d
Autor:
Sophie Papa, Luke Williams, Joseph Dukes, Jamie Rossjohn, Jonathan D Silk, Suzanne Cole, Emily Lam, Samit Kundu, Katarzyna Ward, Duncan Howie, Terri V Cornforth, Nathifa Moyo, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Eleanor M Denham, Gurdyal S Besra, Patricia Illing, Bruce MacLachlan, Julian Vivian, Jeremy Raynes, Jerome Le Nours, Anthony Purcell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/d7d61dd8f23b40c19240771e3414c4c9
Autor:
Clare S. Hardman, Yi-Ling Chen, Marcin Wegrecki, Soo Weei Ng, Robert Murren, Davinderpreet Mangat, John-Paul Silva, Rebecca Munro, Win Yan Chan, Victoria O’Dowd, Carl Doyle, Prashant Mori, Andy Popplewell, Jamie Rossjohn, Daniel Lightwood, Graham S. Ogg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Skin inflammation is often accompanied by systemic disease, yet the pathways that regulate this escalation are little known. Here authors show that transgenic expression of human CD1a in mice leads to the escalation of experimental skin inflammation
Externí odkaz:
https://doaj.org/article/8f36ea19ce9a4285881dcc232935ca78
Autor:
Marcin Wegrecki, Tonatiuh A. Ocampo, Sachith D. Gunasinghe, Anouk von Borstel, Shin Yi Tin, Josephine F. Reijneveld, Thinh-Phat Cao, Benjamin S. Gully, Jérôme Le Nours, D. Branch Moody, Ildiko Van Rhijn, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
T cell receptors are generally thought to contact antigens presented in an end to end configuration. Here the authors show a geometrically alternate sideways mode of recognition of the antigen-presenting molecule CD1a by a γδ T cell receptor.
Externí odkaz:
https://doaj.org/article/a5eb21242f424541a6a488c362e95bcb
Autor:
Caroline L. Ashley, Brian P. McSharry, Hamish E. G. McWilliam, Richard J. Stanton, Ceri A. Fielding, Rommel A. Mathias, David P. Fairlie, James McCluskey, Jose A. Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells).MethodsT
Externí odkaz:
https://doaj.org/article/53babfbfbc814e488fc54d15c6f86de6
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283194 (2023)
Nsp9 is a conserved accessory component of the coronaviral replication and transcription complex. It is the predominant substrate of nsp12's nucleotidylation activity while also serving to recruit proteins required for viral 5'-capping. Anti-nsp9 spe
Externí odkaz:
https://doaj.org/article/36b3ed925aee42b396cb3271cf3e9250