Target Gene Notebook: Connecting genetics and drug discovery

Autor: Janna Hutz, Jamey Wierzbowski, Mark J. Daly, Mary Pat Reeve, Andrew Kirby

Target Gene Notebook was developed to enable more efficient linking of genetic associations to functional biological information. This process is essential to translating genetic insights into therapeutic hypotheses and, eventually, drug discovery. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce42b4a3f33120a409d5e0d9eb75444

Protein interaction mapping on a functional shotgun sequence of Rickettsia sibirica

Autor: Kevin McKernan, David J. Saranga, Lynn Doucette-Stamm, Stephanie Bosak, Wei Tao, Douglas Smith, Jamey Wierzbowski, Paul J. McEwan, Joel A. Malek

Publikováno v: Nucleic Acids Research. 32:1059-1064

Protein interaction maps can reveal novel pathways and functional complexes, allowing 'guilt by association' annotation of uncharacterized proteins. To address the need for large-scale protein interaction analyses, a bacterial two-hybrid system was c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9076a1493d3951a6f8eef30801e2e90b
https://doi.org/10.1093/nar/gkh254

Initial sequencing and comparative analysis of the mouse genome

Autor: Laura Elnitski, David B. Jaffe, Jia Li, Marina Alexandersson, Michael J. Morgan, Shiaw Pyng Yang, Robert Baertsch, Claire M. Wade, John Tromp, Michael C. Zody, Terrence S. Furey, Emma Overton-Larty, Stephen D. Brown, Scott Schwartz, Diane M. Dunn, J. P. Leger, Kris A. Wetterstrand, David Torrents, Ratna Shownkeen, Brian Schultz, Kim C. Worley, Richard D. Emes, John Mayer, Tom Landers, Beverley Meredith, Carol Scott, R. J. Weber, Sean R. Eddy, David Kulp, Jun Kawai, J Bailey, Fan Hsu, Diana L. Kolbe, Kirsten McLay, Marc Botcherby, Richard Mott, Tracie L. Miner, Jill P. Mesirov, Cristyn Kells, Michael A. Quail, Melanie M. Wall, Alistair G. Rust, Josep F. Abril, Ian F Korf, Peter An, Roderic Guigó, Abel Ureta-Vidal, Evan Mauceli, L. Steven Johnson, Arian F.A. Smit, Arkadiusz Kasprzyk, Michael C. Wendl, Deanna M. Church, Francis S. Collins, Wayne N. Frankel, Pallavi Eswara, Bin Ma, Robert H. Waterston, Stylianos E. Antonarakis, Edward M. Rubin, John Douglas Mcpherson, Andrew Sheridan, Megan McCarthy, Ming Li, Colin N. Dewey, Justin Deri, Rosie Levine, Matthew Jones, Sheila Dodge, Richard R. Copley, Leo Goodstadt, Shan Yang, Donna Maglott, Jamey Wierzbowski, Nick Goldman, Evgeny M. Zdobnov, Simon G. Gregory, C M Clee, Steven Leonard, Elaine R. Mardis, Simon C. Potter, Sarah Sims, Richard A. Gibbs, Mark S. Guyer, Francesca Chiaromonte, Susan Lucas, Mark Diekhans, Steve Searle, Rachel Ainscough, Jane Peterson, Emmanouil T. Dermitzakis, Robert Nicol, Lucy Matthews, Guy Slater, Adam Felsenfeld, Karen Foley, Lucinda Fulton, Tim Hubbard, Richard K. Wilson, Deana W. LaHillier, W. Richard McCombie, Johanna Thompson, Robert David, John Attwood, Anthony P. West, Jane Rogers, Evan Keibler, Lisa Cook, Raju Kucherlapati, Steven Seaman, William E. Nash, Ian J. Jackson, Jonathan Singer, Axin Hua, Tina Graves, Ted Sharpe, Dudley Wyman, Bruce W. Birren, Stuart McLaren, David Willey, A Joy, Douglas Smith, Alexandre Reymond, Paul Flicek, Simon Cawley, Richa Agarwala, Diane Gage, Evanne Trevaskis, Ginger A. Fewell, Michael R. Brent, Tracy C. Ponce, W. James Kent, Timothy Holzer, Eduardo Eyras, Michael J. O’Connor, Webb Miller, Donna M. Muzny, Andrew von Niederhausern, Inna Dubchak, Eitan E. Winter, Catherine Ucla, Arne Stabenau, Michael N. Nhan, Piero Carninci, Michele Clamp, Pavel A. Pevzner, James Meldrim, Tim Cutts, R. D. Campbell, Joy Davies, Wratko Hlavina, Elinor K. Karlsson, David Haussler, John Burton, Peer Bork, Nicole Stange-Thomann, Mikita Suyama, Mark J. Daly, Ewan Birney, Edward J. Kulbokas, Craig Pohl, James C. Mullikin, Chad Nusbaum, Genís Parra, Jade P. Vinson, Yoshihide Hayashizaki, Sante Gnerre, Eric Berry, Daniel G. Brown, Asif T. Chinwalla, Emmanuel Mongin, Robert B. Weiss, Raymond Wheeler, Andrew Kirby, Yasushi Okazaki, Lior Pachter, Ross C. Hardison, Brian Spencer, Carol J. Bult, Joanne O. Nelson, Pankaj K. Agarwal, Darren Grafham, Gustavo Glusman, Thomas A. Jones, Glenn Tesler, Simon Whelan, James Cuff, Robert S. Fulton, K F Barlow, Jörg Schultz, Matthias S. Schwartz, Alex Poliakov, Jonathan Butler, Bruce A. Roe, Angela S. Hinrichs, Alan Coulson, Kate Montgomery, Eric D. Green, Stephan Beck, Val Curwen, Krishna M. Roskin, Robert W. Plumb, Chris P. Ponting, Ralph Santos, Victor Sapojnikov, Nicolas Bray, Kymberlie H. Pepin, Charles W. Sugnet, Olivier Couronne, Ivica Letunic, Sophie Williams, Kimberly D. Delehaunty, Kerstin Lindblad-Toh, Zemin Ning, Karen Oliver, Toby Bloom, Michael Kamal, Nicholas J. Dickens, Eric S. Lander, Christine Lloyd, Donna Karolchik, Adrienne Hunt

Publikováno v: Nature, Vol. 420, No 6915 (2002) pp. 520-562

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a37312d8c972e24a67353dfd5e2ad6f
http://ora.ox.ac.uk/objects/uuid:dab3ab6b-6c46-4eb2-822d-01887cdfba9f

Automated hybridization and imaging for chemiluminescence-based multiplex sequencing

Autor: Denise Oriss, Mark Ayers, Hans-Ulrich Thomann, Jamey Wierzbowski, Steven R. Auger, Jen-i Mao

Publikováno v: SPIE Proceedings.

We have developed and are currently using a first generation fully automated hybridizer and sequence imager for multiplex sequencing. This instrument processes four multiplex membranes concurrently with a five hour cycle time, yielding a projected th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84ec83885f8b8541dd3f4e2c023af9ed
https://doi.org/10.1117/12.274365

Discovering drug mode of action using reverse-engineered gene networks

Autor: Jamey Wierzbowski, Timothy S. Gardner, G. Della Gatta, Mukesh Bansal, D. di Bernado

Publikováno v: Scopus-Elsevier

A major challenge in drug discovery is to distinguish the molecular targets of a bioactive compound from the hundreds to thousands of additional gene products that respond indirectly to changes in the activity of the targets. Here, we present an inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbb73b799940b3b3e0e41696208c4bb
http://www.scopus.com/inward/record.url?eid=2-s2.0-33846932795&partnerID=MN8TOARS