Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jamey Mack"'
Autor:
Anne Y. Saiki, Edward T. Olejniczak, Claude G. Lerner, Philip J. Hajduk, Jamey Mack, Steve J. Kakavas, Liping Yu
Publikováno v:
Protein Science. 12:2613-2621
Streptococcus pneumoniae is a major human pathogen that causes high mortality and morbidity and has developed resistance to many antibiotics. We show that the gene product from SP1603, identified from S. pneumoniae TIGR4, is a CMP kinase that is esse
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Publikováno v:
Journal of Biomolecular NMR. 34:221-227
Fluorine atoms are often incorporated into drug molecules as part of the lead optimization process in order to improve affinity or modify undesirable metabolic and pharmacokinetic profiles. From an NMR perspective, the abundance of fluorinated drug l
Autor:
Jamey Mack, Liping Yu, Philip J. Hajduk, Edward T. Olejniczak, Qiulong Huang, Stephen W. Fesik, Zhihong Liu, Angelo Gunasekera, Andrew M. Petros, Nan Xu
Publikováno v:
Biochemistry. 43:6059-6063
The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-termi
Autor:
Claude G. Lerner, Philip J. Hajduk, Stephen W. Fesik, Bruce A. Beutel, Xiaoan Ruan, Jamey Mack, Danli L. Towne, Stephen F. Betz
Publikováno v:
SLAS Discovery. 7:429-432
A strategy is described for the development of high-throughput screening assays against targets of unknown function that involves the use of nuclear magnetic resonance (NMR) spectroscopy. Using this approach, molecules that bind to the protein target
Autor:
Edward T. Olejniczak, Angelo Gunasekera, Xiaoan Ruan, Claude G. Lerner, Linda E. Chovan, Jamey Mack, Liping Yu, Stephen W. Fesik, Danli L. Towne
Publikováno v:
Journal of Molecular Biology. 311:593-604
Streptococcus pneumoniae is a major human pathogen that causes high mortality and morbidity rates and has developed resistance to many antibiotics. The genome of S. pneumoniae has recently been completely sequenced revealing many genes encoding hypot
Publikováno v:
Journal of Biomolecular NMR. 20:105-110
Haemophilus influenzae is a gram-negative pathogen that causes infections ranging from asymptomatic colonization of the human upper respiratory tract to serious invasive diseases such as meningitis. Although the genome of Haemophilus influenzae has b
Autor:
ANDREW M. PETROS, DAVID G. NETTESHEIM, YI WANG, EDWARD T. OLEJNICZAK, ROBERT P. MEADOWS, JAMEY MACK, KERRY SWIFT, EDMUND D. MATAYOSHI, HAICHAO ZHANG, CRAIG B. THOMPSON, STEPHEN W. FESIK
Publikováno v:
Protein Science. 9:2528-2534
Autor:
and Stephen F. Betz, Renaldo Mendoza, Jamey Mack, Philip J. Hajduk, Stephen W. Fesik, David J. Augeri, Jianguo Yang
Publikováno v:
Journal of the American Chemical Society. 122:7898-7904
A method is described for NMR-based screening that involves monitoring the 13C/1H chemical shift changes of a protein selectively labeled with 13C at the methyl groups of valine, leucine, and isoleucine (δ1 only). Using this approach, the sensitivit
Autor:
Renaldo Mendoza, Andrew M. Petros, Jeffrey R. Huth, Chaohong Sun, Stephen W. Fesik, Saul H. Rosenberg, Karl A. Walter, Philip J. Hajduk, Sarah A. Dorwin, Cheol-Min Park, Wang Xilu, Thorsten Oost, Paul Nimmer, Emily Gramling, Haichao Zhang, Hong Ding, Uri S. Ladror, Steven W. Elmore, Jamey Mack
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
The Bcl-2 family of proteins plays a major role in the regulation of apoptosis, or programmed cell death. Overexpression of the anti-apoptotic members of this family (Bcl-2, Bcl-xL, and Mcl-1) can render cancer cells resistant to chemotherapeutic age