Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Jamey D. Young"'
Autor:
Anna Hemnes, Niki Fortune, Katie Simon, Irina A. Trenary, Sheila Shay, Eric Austin, Jamey D. Young, Evan Britain, James West, Megha Talati
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundIn PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly on the use of a single “omic” modality to describe a single deranged pathway. We i
Externí odkaz:
https://doaj.org/article/22d6d48498684b8396f4cc91e68694e9
Autor:
Tomasz K. Bednarski, Mohsin Rahim, Clinton M. Hasenour, Deveena R. Banerjee, Irina A. Trenary, David H. Wasserman, Jamey D. Young
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100558- (2024)
Metabolic dysfunction-associated steatotic liver disease is the most common form of liver disease and poses significant health risks to patients who progress to metabolic dysfunction-associated steatohepatitis. Fatty acid overload alters endoplasmic
Externí odkaz:
https://doaj.org/article/c47f295c40d14743bbad10fcd129e345
Autor:
Shrikaar Kambhampati, Allen H. Hubbard, Somnath Koley, Javier D. Gomez, Frédéric Marsolais, Bradley S. Evans, Jamey D. Young, Doug K. Allen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The capacity to leverage high resolution mass spectrometry (HRMS) with transient isotope labeling experiments is an untapped opportunity to derive insights on context-specific metabolism, that is difficult to assess quantitatively. Tools are
Externí odkaz:
https://doaj.org/article/b82b9f0b68954a4aa01e8f19ebdf163c
Publikováno v:
Metabolites, Vol 14, Iss 6, p 318 (2024)
Metabolic reprogramming is a hallmark of cancer, driving the development of therapies targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool for monitoring cancer metabolism both in vitro and in vivo. Advances in ins
Externí odkaz:
https://doaj.org/article/f2c48288a2424babbabd1e2ed8553675
Autor:
Aaron J. Robinson, Geoffrey L. House, Demosthenes P. Morales, Julia M. Kelliher, La Verne Gallegos-Graves, Erick S. LeBrun, Karen W. Davenport, Fabio Palmieri, Andrea Lohberger, Danaé Bregnard, Aislinn Estoppey, Matteo Buffi, Christophe Paul, Thomas Junier, Vincent Hervé, Guillaume Cailleau, Simone Lupini, Hang N. Nguyen, Amy O. Zheng, Luciana Jandelli Gimenes, Saskia Bindschedller, Debora F. Rodrigues, James H. Werner, Jamey D. Young, Pilar Junier, Patrick S. G. Chain
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Robinson et al. explore bacterial associations in over 700 phylogenetically diverse fungal isolates with 16 S rRNA sequencing of fungal collections from across the globe and bioinformatic screening of publicly available fungal genome sequencing proje
Externí odkaz:
https://doaj.org/article/e24782a4eeaf4c62ab52d7064ee1bf0d
Autor:
Ryan M. Esquejo, Bina Albuquerque, Anna Sher, Matthew Blatnik, Kyle Wald, Matthew Peloquin, Jake Delmore, Erick Kindt, Wenlin Li, Jamey D. Young, Kim Cameron, Russell A. Miller
Publikováno v:
Heliyon, Vol 8, Iss 10, Pp e11091- (2022)
The AMP-activated protein kinase (AMPK) is a cellular sensor of energetics and when activated in skeletal muscle during contraction can impart changes in skeletal muscle metabolism. Therapeutics that selectively activate AMPK have been developed to l
Externí odkaz:
https://doaj.org/article/562c57ec9403415c8a4d1c794d7ddf54
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The metabolic pathways used by microbes to degrade guanidine or mitigate its toxicity remain unclear. Here, the authors report a guanidine degrading enzyme that controls genomic stability of ethylene producing cyanobacterial strains.
Externí odkaz:
https://doaj.org/article/f280440927ac48ad9bacbed764fcd27b
Autor:
Clinton M. Hasenour, Arion J. Kennedy, Tomasz Bednarski, Irina A. Trenary, Brandon J. Eudy, Robin P. da Silva, Kelli L. Boyd, Jamey D. Young
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 5, Pp 707-721 (2020)
Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH). The factors that control progressio
Externí odkaz:
https://doaj.org/article/00483672a33b4e59bd5bd114c8ed4600
Autor:
Mohsin Rahim, Clinton M. Hasenour, Tomasz K. Bednarski, Curtis C. Hughey, David H. Wasserman, Jamey D. Young
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
The liver is the major source of glucose production during fasting under normal physiological conditions. However, the kidney may also contribute to maintaining glucose homeostasis in certain circumstances. To test the ability of the kidney to compen
Externí odkaz:
https://doaj.org/article/e38a1f84ddad44a6850efd5dbd70d9e4
Autor:
Karin J. Bosma, Mohsin Rahim, James K. Oeser, Owen P. McGuinness, Jamey D. Young, Richard M. O'Brien
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101043- (2020)
Objective: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycl
Externí odkaz:
https://doaj.org/article/4701c9a4aec148bc85868d0b7a48679f