Zobrazeno 1 - 10
of 39
pro vyhledávání: '"James Y. H. Li"'
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Single-cell transcriptional and epigenomics profiles have been applied in a variety of tissues and diseases for discovering new cell types, differentiation trajectories, and gene regulatory networks. Many methods such as Monocle 2/3, URD, and STREAM
Externí odkaz:
https://doaj.org/article/efc20b482dfa4591b48057d14f83fbd7
Autor:
Michael Li, Jacob Macro, Kali Meadows, Dushyant Mishra, Dominique Martin, Sara Olson, Billy Joe Huggins, Brenton Graveley, James Y. H. Li, Blanka Rogina
Caloric restriction (CR) delays the onset of age-related changes and extends lifespan in most species, but how late in life organisms benefit from switching to a low-calorie (L) diet is unexplored. We transferred wild type male flies from a high- (H)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1de18a16b1f5e2db517c6f6201ea9e1
https://doi.org/10.1101/2023.05.11.540262
https://doi.org/10.1101/2023.05.11.540262
Publikováno v:
Science advances. 8(13)
Recent studies using single-cell RNA-sequencing have revealed cellular heterogeneity in the developing mammalian cerebellum, yet the regulatory logic underlying this cellular diversity remains to be elucidated. Using integrated single-cell RNA and AT
Recent studies using single-cell RNA-seq have revealed cellular heterogeneity in the developing mammalian cerebellum, yet the regulatory logic underlying this cellular diversity remains to be elucidated. Using integrated single-cell RNA and ATAC anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44610e20d5b015265d175e41c7a5a54d
https://doi.org/10.1101/2021.08.08.455565
https://doi.org/10.1101/2021.08.08.455565
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47111 (2012)
Unlike the laminar arrangement of neurons in the neocortex, thalamic neurons aggregate to form about dozens of nuclei, many of which make topographic connections with specific areas in the neocortex. The molecular mechanisms underlying the formation
Externí odkaz:
https://doaj.org/article/933a6db36bb94bbe9cdf2565eaa485c6
Autor:
Alan W. Leung, James Y. H. Li
Publikováno v:
The Cerebellum. 17:42-48
Evolution of complex behaviors in higher vertebrates and primates require the development of sophisticated neuronal circuitry and the expansion of brain surface area to accommodate the vast number of neuronal and glial populations. To achieve these g
Autor:
James Y. H. Li, Alan W. Leung
Publikováno v:
Journal of cellular physiology. 234(11)
Existing methodologies to produce human neural stem cells and neurons from embryonic stem cells frequently involve multistep processes and the use of complex and expensive media components, cytokines or small molecules. Here, we report a simple techn
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
SUMMARYWe applied single-cell RNA sequencing to profile genome-wide gene expression in about 9,400 individual cerebellar cells from the mouse embryo at embryonic day 13.5. Reiterative clustering identified the major cerebellar cell types and subpopul
Autor:
James Y. H. Li, Qiuxia Guo
Publikováno v:
Development
The embryonic diencephalon gives rise to diverse neuronal cell types, which form complex integration centers and intricate relay stations of the vertebrate forebrain. Prior anecdotal gene expression studies suggest several developmental compartments