Zobrazeno 1 - 10
of 47
pro vyhledávání: '"James Wymer"'
Autor:
Ram B. Khattri, Lauryn Z. Louis, Kyoungrae Kim, Erik M. Anderson, Brian Fazzone, Kenneth C. Harland, Qiongyao Hu, Kerri A. O’Malley, Scott A. Berceli, James Wymer, Terence E. Ryan, Salvatore T. Scali
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract For end-stage kidney disease (ESKD) patients, hemodialysis requires durable vascular access which is often surgically created using an arteriovenous fistula (AVF). However, some ESKD patients that undergo AVF placement develop access-related
Externí odkaz:
https://doaj.org/article/416041defcbb479abe457180143b74a9
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 8, Pp 1296-1304 (2023)
Abstract Objective No efficacious treatments exist to improve or prolong bulbar functions of speech and swallowing in persons with amyotrophic lateral sclerosis (pALS). This study evaluated the short‐term impact of dextromethorphan/quinidine (DMQ)
Externí odkaz:
https://doaj.org/article/db1bf0b53b9e4f3293dcfbe5213ae556
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-19 (2022)
Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in which many processes are detected including (neuro)inflammation. Many drugs have been tested for ALS in clinical trials but most have failed to reach their pri
Externí odkaz:
https://doaj.org/article/63dcc99656794436b446e75ffd3caf2c
Publikováno v:
Interdisciplinary Neurosurgery, Vol 23, Iss , Pp 101005- (2021)
Diffuse midline glioma with H3 K27M mutation is a new tumor entity from 2016 which is highly aggressive and classified as a WHO Grade IV tumor regardless of histopathologic features. We report a case of a 40-year-old male with diffuse midline glioma
Externí odkaz:
https://doaj.org/article/f5baa663c9ad40ffad5988a93541e287
Autor:
Jennifer L Chapin, Lauren Tabor Gray, Terrie Vasilopoulos, Amber Anderson, Lauren DiBiase, Justine Dallal York, Raele Robison, James Wymer, Emily K Plowman
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236804 (2020)
ObjectiveThe ALS Functional Rating Scale-Revised (ALSFRS-R) is the most commonly utilized instrument to index bulbar function in both clinical and research settings. We therefore aimed to evaluate the diagnostic utility of the ALSFRS-R bulbar subscal
Externí odkaz:
https://doaj.org/article/171dc413886644e7978a6cc516da5fad
Autor:
Lauren Tabor Gray, Kasey L. McElheny, Terrie Vasilopoulos, James Wymer, Barbara K. Smith, Emily K. Plowman
Publikováno v:
Dysphagia. 38:719-725
Autor:
Michael Pulley, Mikko Kuoppamäki, Carolyn A Young, Jesus S. Mora Pardina, Kumaraswamy Sivakumar, Toni Sarapohja, Michael A. Elliott, Chafic Karam, Sandeep Rana, Orla Hardiman, Nathan P. Staff, Letizia Mazzini, Gabriele Mora, Thomas F. Meyer, Colleen O'Connell, Stéphanie Delstanche, Elham Bayat, Michael D. Weiss, Waqar Waheed, Nenad Mitrovic, Philippe Corcia, Marie-Hélène Soriani, Edward J. Kasarskis, Claudia Caponnetto, Dale J. Lange, Tuan Vu, Leo McCluskey, Berthold Schrank, Angela Genge, Matthew C. Kiernan, Valtteri V Aho, Manu Jokela, Philip Van Damme, Juan F. Vázquez Costa, Maurizio Inghilleri, Wolfgang Löscher, David Schultz, Tero Tapiola, Susanne Petri, Adriano Chiò, Gary L. Pattee, Julian Großkreutz, Ammar Al-Chalabi, Aziz Shaibani, Susan Mathers, Kevin J. Felice, Kimberly Goslin, James Caress, Matthias Boentert, Albert C. Ludolph, Aleksandar Radunovic, Robert D. Henderson, James Wymer, Todd Levine, Jakob Rath, Merrilee Needham, William Camu, Gaurav Guliani, Rune Johansson, Leonard H. van den Berg, Namita Goyal, Mark B. Bromberg, Bjorn Oskarsson, Annie Dionne, Eduardo Locatelli, Brent T. Harris, Suma Babu, Richard Bedlack, John Ravits, Jinsy A. Andrews, Philippe Couratier, Gabriele Siciliano, Hannu Laaksovirta, Kourosh Rezania, Lawrence Korngut, Eduardo Aguera Morales, Peter M Andersen, Eva Farrero Munoz, David Lacomis, Stephen N. Scelsa, Chris Garratt, Matthew Burford, Merit Cudkowicz, Nicholas J. Maragakis, Wendy Johnston, Martin M. Brown, Johannes Prudlo, Justin Y. Kwan, Dominic B. Fee, Senda Ajroud-Driss, Stephen A. Goutman, John Turnbull, Michael H. Rivner, Timothy M. Miller, Jan De Bleecker, Caroline Ingre, Luis Varona, Genevieve Matte, Daragh Heitzman, Robert Untucht, Lorne Zinman, Adam Quick, Jonathan S. Katz
Publikováno v:
The Lancet Neurology. 20:821-831
Summary Background There is an urgent unmet need for new therapies in amyotrophic lateral sclerosis. In a clinical study with healthy volunteers, levosimendan, a calcium sensitiser, was shown to improve neuromechanical efficiency and contractile func
Publikováno v:
Clinical pharmacology in drug developmentReferences. 12(1)
Dysphagia is highly prevalent in patients with amyotrophic lateral sclerosis (ALS). Riluzole is a US Food and Drug Administration-approved treatment for ALS. Riluzole oral film (ROF; Exservan™) contains riluzole in a polymer-based film matrix. The
Autor:
Sabrina Paganoni, Hiroshi Mitsumoto, James Wymer, Mary Kay Floeter, Deborah L. Warden, Dale J. Lange
Publikováno v:
Amyotroph Lateral Scler Frontotemporal Degener
Primary lateral sclerosis (PLS) is an extremely rare central nervous system degenerative disorder characterized by slowly progressive upper motor neuron loss leading to severe limb and bulbar dysfunction and disability. Although not necessarily life-
Autor:
Sabrina Paganoni, Suzanne Hendrix, Samuel P Dickson, Newman Knowlton, James D Berry, Michael A Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret Ayo Owegi, Adam Quick, James Wymer, Stephen A Goutman, Daragh Heitzman, Terry D Heiman-Patterson, Carlayne Jackson, Colin Quinn, Jeffrey D Rothstein, Edward J Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq S Ladha, Timothy M Miller, Stephen N Scelsa, Tuan H Vu, Christina Fournier, Kristin M Johnson, Andrea Swenson, Namita Goyal, Gary L Pattee, Suma Babu, Marianne Chase, Derek Dagostino, Meghan Hall, Gale Kittle, Mathew Eydinov, Joseph Ostrow, Lindsay Pothier, Rebecca Randall, Jeremy M Shefner, Alexander V Sherman, Eric Tustison, Prasha Vigneswaran, Hong Yu, Joshua Cohen, Justin Klee, Rudolph Tanzi, Walter Gilbert, Patrick Yeramian, Merit Cudkowicz
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry, vol 93, iss 8
BackgroundCoformulated sodium phenylbutyrate/taurursodiol (PB/TURSO) was shown to prolong survival and slow functional decline in amyotrophic lateral sclerosis (ALS).ObjectiveDetermine whether PB/TURSO prolonged tracheostomy/ventilation-free survival