Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James Whitwell"'
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 1010-1019 (2020)
In vitro studies have supported the toxicological evaluation of chemicals and complex mixtures including cigarette smoke and novel tobacco and nicotine products which include tobacco heating products (THP). This new environment requires faster testin
Externí odkaz:
https://doaj.org/article/170b2553d88141c585682128cac4c3bc
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 1010-1019 (2020)
Toxicology Reports, Vol 7, Iss, Pp 1010-1019 (2020)
Graphical abstract
Highlights • Cigarettes were compared to a tobacco heating product (THP1.0 T) in a comparative study. • Traditional and contemporary IVMN approaches were investigated. • Multiple cell types and scoring methods were emplo
Highlights • Cigarettes were compared to a tobacco heating product (THP1.0 T) in a comparative study. • Traditional and contemporary IVMN approaches were investigated. • Multiple cell types and scoring methods were emplo
Autor:
Sarah Phillips, Julie Clements, Jim Saul, Robert Smith, Darren Kidd, Teresa Chirom, James Whitwell, Nicky Mason
Publikováno v:
Mutagenesis. 36:37-49
Implementation of the seventh amendment to the EU Cosmetics Directive has driven much research into suitable in vitro alternative assays to support satisfactory risk assessments. One such assay is the reconstructed skin micronucleus (RSMN) assay. Fir
Autor:
David, Kirkland, James, Whitwell, Robert, Smith, Kiyohiro, Hashimoto, Zhiying, Ji, Julia, Kenny, Naoki, Koyama, David P, Lovell, Hans-Jörg, Martus, Krista, Meurer, Daniel, Roberts, Akira, Takeiri, Yoshifumi, Uno, Bas-Jan, van der Leede, Paul, White, Andreas, Zeller
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :503503
It is often assumed that genotoxic substances will be detected more easily by using in vitro rather than in vivo genotoxicity tests since higher concentrations, more cytotoxicity and static exposures can be achieved. However, there is a paucity of da
Autor:
Sarah Phillips, Victoria Hargreaves, Gary P. Watters, Teresa Chirom, Julie Clements, Robert Smith, James Whitwell, Mel Lloyd
Publikováno v:
Mutagenesis. 34:217-237
The in vitro micronucleus (IVMN) test was endorsed for regulatory genotoxicity testing with adoption of the Organisation for Economic Co-operation and Development (OECD) test guideline (TG) 487 in 2010. This included two equally acceptable options fo
Autor:
U. Hemmann, Jim Saul, James Whitwell, B.M. van der Leede, Stephen D. Dertinger, P. Escobar, Andreas Zeller, Julia Kenny, Robert Smith, David P. Lovell, R. Fiedler, Laura Custer, Mick D. Fellows
A database of micronuclei counts for historical negative control data from rat in vivo micronuclei tests performed in 10 different laboratories was established. Data were available from over 4000 negative control rats from 10 laboratories. The mean f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ce64fec9cd31402b79b499b439c2ac
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 809:33-42
A range of fibrous materials, including several types of asbestos and carbon fibres with nano scale diameters that had reported positive genotoxicity data (predominantly clastogenicity), were tested in the in vitro micronucleus test (OECD 487) in GLP
Autor:
David Thorne, Betsy Bombick, Damien Breheny, Julie Clements, Robert Leverette, James Whitwell, Marianna Gaça, Mel Lloyd, Stephen McEnaney
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 132
Conduct of the mouse lymphoma assay (MLA) is underpinned by Organisation for Economic Co-operation and Development (OECD) Test Guideline 490 and International Conference on Harmonisation S2(R1) guidance and is a recognised in vitro genotoxicity test
Autor:
Betsy Bombick, Julie Clements, Stephen McEnaney, Robert Leverette, David Thorne, Marianna Gaça, James Whitwell, Mel Lloyd, Damien Breheny
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 132
In this study, a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F Kentucky reference cigarette using the in vitro micronucleus assay. Testing was conducted using two Chinese hamster cell lines (CHO and
Autor:
Ben Gilby, Maik Schuler, Jennifer Y. Tanir, Shambhu K Roy, Kiyohiro Hashimoto, James Whitwell, Azeddine Elhajouji, Christopher S Farabaugh, David P. Lovell, Yan Li, Mick Fellow
A database of the micronuclei counts was built up for historical negative control data from human lymphocyte in vitro micronuclei tests (MnVit) carried out in 8 laboratories with experience of the method. The mean incidence of micronucleated cells (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3065302df8498969d5b3700a7b28928e
https://openaccess.sgul.ac.uk/id/eprint/110519/1/1-s2.0-S1383571818301578-main.pdf
https://openaccess.sgul.ac.uk/id/eprint/110519/1/1-s2.0-S1383571818301578-main.pdf