SARS-CoV-2 booster vaccination rescues attenuated IgG1 memory B cell response in primary antibody deficiency patients

Autor: Frank J. Lin, Alexa Michelle Altman Doss, Hannah G. Davis-Adams, Lucas J. Adams, Christopher H. Hanson, Laura A. VanBlargan, Chieh-Yu Liang, Rita E. Chen, Jennifer Marie Monroy, H. James Wedner, Anthony Kulczycki, Tarisa L. Mantia, Caitlin C. O’Shaughnessy, Saravanan Raju, Fang R. Zhao, Elise Rizzi, Christopher J. Rigell, Tiffany Biason Dy, Andrew L. Kau, Zhen Ren, Jackson S. Turner, Jane A. O’Halloran, Rachel M. Presti, Daved H. Fremont, Peggy L. Kendall, Ali H. Ellebedy, Philip A. Mudd, Michael S. Diamond, Ofer Zimmerman, Brian J. Laidlaw

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundAlthough SARS-CoV-2 vaccines have proven effective in eliciting a protective immune response in healthy individuals, their ability to induce a durable immune response in immunocompromised individuals remains poorly understood. Primary antib

Externí odkaz: https://doaj.org/article/09d941fbe1f542eca1d74a7632944273

Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial

Autor: Joseph K Han, Claus Bachert, Wytske Fokkens, Martin Desrosiers, Martin Wagenmann, Stella E Lee, Steven G Smith, Neil Martin, Bhabita Mayer, Steven W Yancey, Ana R Sousa, Robert Chan, Claire Hopkins, Cecilia Ahlström Emanuelsson, Ledit Ardusso, Michael Armstrong, Philip Bardin, Sara Barnes, Miguel Bergna, Christian Betz, Achim Beule, James Blotter, Valeriu Bronescu, Matthew Brown, Sean Carrie, Adam Chaker, Hyung-Ju Cho, Marie-Noëlle Corriveau, Timothy Courville, Mandy Cuevas, Cecelia Damask, Adam DeConde, Jaime Del Carpio, María De Salvo, Hun-Jong Dhong, Stephen Durham, Anton Edin, Dale Ehmer Jr, Pedro Elías, Adil Fatakia, Christine Franzese, Simon Gane, Gabriel García, Andrew Gillman, Moritz Groeger, Richard Harvey, Johan Hellgren, Thomas Higgins, Jonathan Hobson, Mattias Jangard, Arif Janjua, Naveed Kara, Sergey Karpischenko, Edward Kerwin, Fatimat Khanova, Shaun Kilty, Chang-Hoon Kim, Seontae Kim, Ludger Klimek, Craig LaForce, Samuel Leong, Bradley Marple, Anders Mårtensson, Jorge Maspero, Neil Massey, Jonathan Matz, Chad McDuffie, Corina Mella, Steven Miller, Ekaterina Mirzabekyan, Jonathan Moss, Nayla Mumneh, Robert Nathan, Adriana Neagos, Heidi Olze, Andrey Ovchinnikov, Randall Ow, Dmitriy Polyakov, Doinel Radeanu, Chae-Seo Rhee, Ramón Rojas, Jeffrey Rosenbloom, Sergei Ryazantsev, Chady Sader, Pablo Saez Scherbovsky, Guy Scadding, Rodney Schlosser, Heena Shah-Patel, Ronald Shealy, Ayesha Siddiqi, Stacey Silvers, Narinder Singh, Doron Sommer, Weily Soong, Leigh Sowerby, Peter Spafford, Catalin Stefan, Richard Sterling, Valeriy Svistushkin, Neetu Talreja, Galina Tarasova, Martha Tarpay, Alberto Tolcachier, Karin Toll Toll, Carolina van Schaik, Luke Webb, H James Wedner, Luis Wehbe, Soo Whan Kim, Barbara Wollenberg, Simon Wright, Vladimir Yakusevich, Anahí Yañez, Yury Yarin, David Yen, Hyo Yeol Kim

Publikováno v: lancet. Respiratory medicine, 9(10), 1141-1153. Elsevier Limited

Background: Chronic rhinosinusitis with nasal polyps affects approximately 2–4% of the general population, and long-term use of systemic corticosteroids is associated with adverse effects. The aim of this study was to assess the efficacy and safety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc6772624170fd7c789ee5290b4827b
https://doi.org/10.1016/s2213-2600(21)00097-7

Immunoglobulin replacement products in current clinical use in the United States have poor neutralizing activity against SARS-CoV-2 Omicron strains

Autor: Alexa Doss, Chieh-Yu Liang, Jennifer Monroy, James Wedner, Christopher Rigell, Hannah Davis-Adams, Lucas Adams, Peggy Kendall, Michael Diamond, Ofer Zimmerman

Publikováno v: Clinical Immunology. 250:109463

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0deab238ee2616aafdcd02ae17c8c42e
https://doi.org/10.1016/j.clim.2023.109463

Hereditary angioedema: Pathophysiology (HAE type I, HAE type II, and HAE nC1-INH)

Autor: H. James Wedner

Publikováno v: Allergy and Asthma Proceedings. 41:S14-S17

The pathophysiology of hereditary angioedema (HAE) in virtually all cases is the result of the uncontrolled production of the vasoactive peptide bradykinin. C1 inhibitor (C1-INH) is a serine protease inhibitor, which, under normal circumstances, is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac135150e5922630476505596d752d96
https://doi.org/10.2500/aap.2020.41.200081

mRNA vaccine boosting enhances antibody responses against SARS-CoV-2 Omicron variant in individuals with antibody deficiency syndromes

Autor: Ofer Zimmerman, Alexa Michelle Altman Doss, Paulina Kaplonek, Chieh-Yu Liang, Laura A. VanBlargan, Rita E. Chen, Jennifer Marie Monroy, H. James Wedner, Anthony Kulczycki, Tarisa L. Mantia, Caitlin C. O’Shaughnessy, Hannah G. Davis-Adams, Harry L. Bertera, Lucas J. Adams, Saravanan Raju, Fang R. Zhao, Christopher J. Rigell, Tiffany Biason Dy, Andrew L. Kau, Zhen Ren, Jackson S. Turner, Jane A. O’Halloran, Rachel M. Presti, Daved H. Fremont, Peggy L. Kendall, Ali H. Ellebedy, Galit Alter, Michael S. Diamond

Publikováno v: Cell reports. Medicine. 3(6)

Individuals with primary antibody deficiency (PAD) syndromes have poor humoral immune responses requiring immunoglobulin replacement therapy. We followed individuals with PAD after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29605dfb063ad40b6eed72e775918770
https://pubmed.ncbi.nlm.nih.gov/35688161