Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health

Autor: Srinivas Reddy Pallerla, Dominik Harms, Reimar Johne, Daniel Todt, Eike Steinmann, Mathias Schemmerer, Jürgen J. Wenzel, Jörg Hofmann, James Wai Kuo Shih, Heiner Wedemeyer, C.-Thomas Bock, Thirumalaisamy P. Velavan

Publikováno v: Pathogens, Vol 9, Iss 10, p 856 (2020)

Infection with hepatitis E virus (HEV) represents the most common source of viral hepatitis globally. Although infecting over 20 million people annually in endemic regions, with major outbreaks described since the 1950s, hepatitis E remains an undere

Externí odkaz: https://doaj.org/article/96c1d463838b4fd7a0553d9de1419a7d

In vivo time-related evaluation of a therapeutic neutralization monoclonal antibody against lethal enterovirus 71 infection in a mouse model.

Autor: Zhiqun Li, Longfa Xu, Delei He, Lisheng Yang, Che Liu, Yixin Chen, James Wai Kuo Shih, Jun Zhang, Qinjian Zhao, Tong Cheng, Ningshao Xia

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109391 (2014)

Enterovirus 71 (EV71) is a neurotropic virus capable of inducing severe neurological symptoms and death. No direct targeting antivirals are useful in the treatment of severe EV71 infection. Because of low toxicity and good specificity, monoclonal ant

Externí odkaz: https://doaj.org/article/419330fae4a042fe87b117608ad2399b

Detection and analysis of tupaia hepatocytes via mAbs against tupaia serum albumin

Autor: Lunzhi Yuan, Yali Zhang, Pingguo Liu, Yong Wu, Tong Cheng, Ningshao Xia, Wangheng Hou, Tengyun Wang, James Wai-Kuo Shih, Xuan Liu, Kun Wu, Tianying Zhang, Quan Yuan

Publikováno v: Experimental Animals

On the basis of its close phylogenetic relationship with primates, the development of Tupaia belangeri as an infection animal model and drug metabolism model could provide a new option for preclinical studies, especially in hepatitis virus research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d67260d71d478121696cd7174d0d6a
https://doi.org/10.1538/expanim.15-0086

Hepatitis E

Autor: Juraj Petrik, Miguel Lozano, Clive R. Seed, Helen M. Faddy, Anthony J. Keller, Patricia Santos Prado Scuracchio, Silvano Wendel, Anton Andonov, Margaret Fearon, Gilles Delage, Jun Zhang, James Wai Kuo Shih, Pierre Gallian, Rachid Djoudi, Pierre Tiberghien, Jacques Izopet, Jens Dreier, Tanja Vollmer, Cornelius Knabbe, Rakesh Aggarwal, Amit Goel, Anna Rita Ciccaglione, Keiji Matsubayashi, Masahiro Satake, Kenji Tadokoro, Sook-Hyang Jeong, Hans L. Zaaijer, Eugene Zhiburt, Jason Chay, Diana Teo, Sze Sze Chua, Maria Piron, Silvia Sauleda, José-Manuel Echevarría, Harry Dalton, Susan L. Stramer

Publikováno v: Vox Sanguinis
Vox Sanguinis, 2015, ⟨10.1111/vox.12285⟩
Vox Sanguinis, Wiley, 2015, ⟨10.1111/vox.12285⟩
Vox sanguinis, 110(1), 93-130. Wiley-Blackwell

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cee69b2e521fb3b2e354c7a4a68f3f
https://doi.org/10.1111/vox.12285

A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses

Autor: Timothy Alefantis, Svetlana Stegalkina, Mujing Fang, Junyu Chen, Honglin Chen, Xiaoyang Cai, Quan Yuan, Ningshao Xia, Wang Guosong, Zhang Limin, Hai Yu, Yixin Chen, Jing Chen, Minwei Zhang, Wenxin Luo, Chenguang Shen, Zizheng Zheng, Xingjian Bi, Kunyu Yang, Jian-Li Cao, Rui Li, James Wai-Kuo Shih, Zhang Mengya, Harry Kleanthous, Stephen Anderson, Jun Zhang, Qingbing Zheng

Publikováno v: Science Translational Medicine. 9

Influenza B virus causes considerable disease burden worldwide annually, highlighting the limitations of current influenza vaccines and antiviral drugs. In recent years, broadly neutralizing antibodies (bnAbs) against hemagglutinin (HA) have emerged

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46be6556b0095c860d8fb295ea32fe7b
https://doi.org/10.1126/scitranslmed.aam5752