Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James W.S. Jahng"'
Autor:
Lu Ren, James W.S. Jahng, Nadjet Belbachir, Zachary Cook, Gabriela C. Rivero, Marco V. Perez, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 78, Iss , Pp 103443- (2024)
Long QT Syndrome (LQTS) is a genetic heart disorder that can induce cardiac arrhythmias. The most prevalent subtype, LQT1, stems from rare variants in the KCNQ1 gene. Utilizing induced pluripotent stem cells (iPSCs) enables detailed cellular studies
Externí odkaz:
https://doaj.org/article/de71c1b3b7b340e2afa8616a8ec67386
Autor:
Gaoxian Chen, Lorena Orozco, Sophia Parmisano, James W.S. Jahng, Carlos D. Vera, Yan Zhuge, Joseph C. Wu, Detlef Obal
Publikováno v:
Stem Cell Research, Vol 72, Iss , Pp 103218- (2023)
Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease, with an estimated 500–1000 new cases diagnosed every year. A portion of these cases may be caused by mutations in the BMPR2 gene, suggesting a possible genetic component in the de
Externí odkaz:
https://doaj.org/article/e091d86e6af746e1ae827664b860c6fc
Autor:
Amit Manhas, James W.S. Jahng, Carlos D. Vera, Sushma P. Shenoy, Joshua W. Knowles, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 61, Iss , Pp 102774- (2022)
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disorder characterized by a thick left ventricular wall and an increased risk of arrhythmias, heart failure, and sudden cardiac death. The MYBPC3 and PRAKG2 are known causal genes for HCM. Her
Externí odkaz:
https://doaj.org/article/6f63f2c69f1b4f0f8df1d7bde7132bc1
Autor:
Xu Cao, James W.S. Jahng, Chelsea Lee, Yanjun Zha, Matthew T. Wheeler, Karim Sallam, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102455- (2021)
MYH7 heterozygous mutations are common genetic causes of hypertrophic cardiomyopathy (HCM). HCM is characterized by hypertrophy of the left ventricle and diastolic dysfunction. We generated three human induced pluripotent stem cell (iPSC) lines from
Externí odkaz:
https://doaj.org/article/4ceca967b84a4c788c756397e690684c
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102492- (2021)
Congenital long QT syndrome type 1 (LQT1) results from KCNQ1 mutations that cause loss of Kv7.1 channel function, leading to arrhythmias, syncope, and sudden cardiac death. Here, we generated three human-induced pluripotent stem cell (iPSC) lines fro
Externí odkaz:
https://doaj.org/article/0bc67b6bd06c4baebc129c0c44e317b1
Autor:
Gema Mondéjar-Parreño, James W.S. Jahng, Nadjet Belbachir, Blake C. Wu, Xiaolan Zhang, Marco V. Perez, Nitish Badhwar, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 54, Iss , Pp 102402- (2021)
Congenital long QT syndrome type 2 (LQT2) results from KCNH2 mutations that cause loss of Kv11.1 channel function which can lead to arrhythmias, syncope, and sudden death. Here, we generated three human-induced pluripotent stem cell (iPSC) lines from
Externí odkaz:
https://doaj.org/article/d87f8252619345a6b2908e70912149e9
Autor:
Lichao Liu, Sushma P. Shenoy, James W.S. Jahng, Yu Liu, Joshua W. Knowles, Yan Zhuge, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102279- (2021)
Hypertrophic cardiomyopathy (HCM) is an inherited heart disease that can cause sudden cardiac death and heart failure. HCM often arises from mutations in sarcomeric genes, among which the MYBPC3 is the most frequently mutated. Here we generated two h
Externí odkaz:
https://doaj.org/article/ae45f8775d8741b5836cc5f93aab274b
Autor:
James W.S. Jahng, Katelyn E. Black, Lichao Liu, Hye Ryeong Bae, Marco Perez, Euan A. Ashley, Karim Sallam, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102284- (2021)
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited heart disease which can cause life-threatening ventricular arrhythmias and cardiac dysfunction. The autosomal dominant form of ARVD/C is caused by mutations in the car
Externí odkaz:
https://doaj.org/article/702a30b9a42f4ef7ab9f9ca919b6d417
Publikováno v:
Circulation Research. 130:978-980
Autor:
James W.S. Jahng, Joseph C. Wu
Publikováno v:
Mol Ther
Fibroblasts can be reprogrammed into cardiovascular progenitor cells (CPCs) using transgenic approaches, although the underlying mechanism remains unclear. We determined whether activation of endogenous genes such as Gata4, Nkx2.5, and Tbx5 can rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddddd52e2275d0169787025f6fd64b0
https://europepmc.org/articles/PMC8753518/
https://europepmc.org/articles/PMC8753518/