Zobrazeno 1 - 10
of 32
pro vyhledávání: '"James W. Yockman"'
Autor:
Donald L. Atkinson, Warren Sherman, David A. Bull, Dolly J. Holt, David W. Grainger, V. Vargas, Monica P. Revelo, Amit N. Patel, F. Silva, Sihem Boudina, James W. Yockman
Publikováno v:
Stem Cells. 32:572-581
Brown adipose tissue (BAT) plays a key role in the evolutionarily conserved mechanisms underlying energy homeostasis in mammals. It is characterized by fat vacuoles 5–10 μm in diameter and expression of uncoupling protein one, central to the regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1628caa456eb01ebfc2171178d350b9d
https://doi.org/10.1002/stem.1595
https://doi.org/10.1002/stem.1595
Publikováno v:
Journal of Controlled Release. 159:111-119
The clinical success of non-viral gene delivery reagents is hampered by their inefficient cellular transgene delivery, which is largely influenced by carrier properties that are currently undefined and misunderstood. In an attempt to further define a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d412380fe558653398addb0ba915c618
https://doi.org/10.1016/j.jconrel.2012.01.010
https://doi.org/10.1016/j.jconrel.2012.01.010
Autor:
Sung Wan Kim, Tae-il Kim, Jaesung Kim, Chae-Ok Yun, Pyung-Hwan Kim, Hye Yeong Nam, Min Jung Kim, James W. Yockman
Publikováno v:
Biomaterials. 32:9328-9342
Systemic administration of adenovirus (Ad) vectors is complicated by host immune responses and viral accumulation in the liver, resulting in a short circulatory virus half-life, low efficacy, and host side effects. Ad surface modification is thus req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385a5ad28fed6799a03edf2e231df61d
https://doi.org/10.1016/j.biomaterials.2011.08.066
https://doi.org/10.1016/j.biomaterials.2011.08.066
Publikováno v:
Biomaterials. 32:5213-5222
The primary cardiomyocyte-specific peptide (PCM) and the cell-penetrating peptide (CPP), HIV-Tat (49-57), were incorporated into the polymer, cystamine bisacrylamide-diaminohexane (CBA-DAH), to increase the delivery of RNAi to target cells, specifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fde050caaed44aa15762843eda573c3
https://doi.org/10.1016/j.biomaterials.2011.03.058
https://doi.org/10.1016/j.biomaterials.2011.03.058
Bioreducible polymer-transfected skeletal myoblasts for VEGF delivery to acutely ischemic myocardium
Autor:
Mei Ou, Hye Yeong Nam, James W. Yockman, Catherine M. Straub, Arlo N. McGinn, Sung Wan Kim, Norman Hu, David A. Bull
Publikováno v:
Biomaterials. 32:942-949
Implantation of skeletal myoblasts to the heart has been investigated as a means to regenerate and protect the myocardium from damage after myocardial infarction. While several animal studies utilizing skeletal myoblasts have reported positive findin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce6febd3060907f8c82b2c285aa3fdb
https://doi.org/10.1016/j.biomaterials.2010.09.061
https://doi.org/10.1016/j.biomaterials.2010.09.061
Publikováno v:
Biomaterials. 31:1865-1874
Adenoviral vectors offer many advantages for cancer gene therapy, including high transduction efficiency, but safety concerns related to severe immunogenicity and other side effects have led to careful reconsideration of their use in human clinical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea79107fafab5de618343728a044a86
https://doi.org/10.1016/j.biomaterials.2009.11.043
https://doi.org/10.1016/j.biomaterials.2009.11.043
Publikováno v:
Journal of Controlled Release. 142:61-69
This study was designed to assess the in vitro gene expression efficiency and therapeutic effectiveness of polymer mediated transfection of primary myoblasts. Autologous primary myoblast transplantation may improve the function of infarcted myocardiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41436ef767147953fc443904bd44a757
https://doi.org/10.1016/j.jconrel.2009.09.021
https://doi.org/10.1016/j.jconrel.2009.09.021
Autor:
Harold M. Erickson, Minhyung Lee, Aida Albanil, James W. Yockman, Donghoon Choi, Andrew Kastenmeier, Matthew G. Whitten, Chien-Wen Chang, David A. Bull, Sung Wan Kim
Publikováno v:
Gene Therapy. 16:127-135
The development of clinically beneficial myocardial gene therapy has been slowed by reliance on the use of viral carriers and non-physiologic, constitutive gene expression. To specifically address these issues, we have developed a non-viral gene carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467c658c3396e57eb7ae35b059f33b05
https://doi.org/10.1038/gt.2008.146
https://doi.org/10.1038/gt.2008.146
Publikováno v:
Pharmaceutical Research. 24:1079-1087
Polymeric nucleic acid carriers are designed to overcome one or more barriers to delivery. High molecular weight polyethylenimine (PEI) shows high transfection efficiency but exhibits high cytotoxicity (Fischer et al. Biomaterials, 24:1121–1131 (20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0992c3361a97bb946c219b016ca58f43
https://doi.org/10.1007/s11095-006-9229-5
https://doi.org/10.1007/s11095-006-9229-5
Autor:
Jan Feijen, Sung Wan Kim, Lane V. Christensen, Wim E. Hennink, Zhiyuan Zhong, Yong Hee Kim, James W. Yockman, Martin C. Lok
Publikováno v:
Biomacromolecules, 6(6), 3440-3448. American Chemical Society
Novel ABA triblock copolymers consisting of low molecular weight linear polyethylenimine (PEI) as the A block and poly(ethylene glycol) (PEG) as the B block were prepared and evaluated as polymeric transfectant. The cationic polymerization of 2-methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0103ac53455aaaef573916bce84ef3
https://doi.org/10.1021/bm050505n
https://doi.org/10.1021/bm050505n