Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James W. Van Huysse"'
Autor:
Jian Zhou, Michael J. Martinez, Tohti Amet, Guangli Wang, Christina J. Miller, Brian K. Kay, James W. Van Huysse, Sanofar J. Abdeen, Ronald R. Bowsher, Jennifer E. McGinnis, Erica Simmons
Publikováno v:
New Biotechnology
A phage library displaying 1010 variants of the fibronectin type III (FN3) domain was affinity selected with the biotinylated form of the receptor binding domain (RBD, residues 319-541) of the SARS-CoV-2 virus spike protein. Nine binding FN3 variants
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 90:83-88
Na+,K+-ATPase is a heterodimer consisting of catalytic α1–α4 and regulatory β1–β3 subunits. Recently, we reported that transfection with ouabain-resistant α1R-Na+,K+-ATPase rescues renal epithelial C7-MDCK cells exclusively expressing the ou
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H2147-H2153
A chronic increase in the concentration of sodium chloride in the cerebrospinal fluid (CSF) (↑CSF [NaCl]) appears to be critically important for the development of salt-dependent hypertension. In agreement with this concept, increasing CSF [NaCl] c
Autor:
Xiaohong Hou, Iva Dostanic-Larson, Amy E. Moseley, James W. Van Huysse, Stephanie A. Dean, Steven F. Theriault, Jerry B. Lingrel, Hengwei Wu
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 296:R1427-R1438
Intracerebroventricular (ICV) infusion of NaCl mimics the effects of a high-salt diet in salt-sensitive hypertension, raising the sodium concentration in the cerebrospinal fluid (CSF [Na]) and subsequently increasing the concentration of an endogenou
Autor:
James W. Van Huysse
Publikováno v:
Pathophysiology. 14:213-220
An endogenous ouabain-like substance (OLS) plays a critical role in the etiology of experimental models of human hypertension induced by a high salt diet. Early on, evidence for a role of this Na, K-ATPase inhibitor in blood pressure regulation was p
Autor:
John N. Lorenz, James W. Van Huysse, Iva Dostanic-Larson, Jerry B. Lingrel, Jon C. Neumann, Amy E. Moseley
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 290:R524-R528
An interesting feature of Na+-K+-ATPase is that it contains four isoforms of the catalytic α-subunit, each with a tissue-specific distribution. Our laboratory has used gene targeting to define the functional role of the α1- and α2-isoforms. While
Publikováno v:
Brain Research. 1018:171-180
In normotensive rats, chronic infusion of exogenous ouabain causes hypertension involving central mechanisms. To determine whether ouabain-induced hypertension is associated with specific changes in brain Na+,K+-ATPase activity and expression, we ass
Publikováno v:
Brain Research. 944:124-134
The objective of the present study was to test the hypothesis that brain Na, K-ATPase expression and/or activity is altered following an increase in blood pressure produced by constriction of the abdominal aorta just proximal to the renal arteries. A
Publikováno v:
Journal of Hypertension. 19:89-98
Objectives To assess changes in the activity of the brain renin-angiotensin system during (i) the development of salt-sensitive hypertension; and (ii) the prevention of salt-sensitive hypertension by blocking brain 'ouabain'. Methods In protocol I, a
Publikováno v:
FEBS Letters. 389:179-185
At two intramembrane carboxyl-containing amino acids of the sheep alpha1 isoform of Na,K-ATPase (Asp804 and Asp808), both charge-conserving (Asp to Glu) and charge-deleting (Asp to Asn, Leu and Ala) replacements were made and the altered enzymes stud