Zobrazeno 1 - 10
of 32
pro vyhledávání: '"James W. Purcell"'
Autor:
James W. Purcell, Han K. Kim, Sonia G. Tanlimco, Minhtam eDoan, Melvin eFox, Peter eLambert, Debra T. Chao, Mien eSho, Keith E. Wilson, Gary C. Starling, Patricia A. Culp
Publikováno v:
Frontiers in Immunology, Vol 4 (2014)
TweakR is a TNF receptor family member, whose natural ligand is the multifunctional cytokine TWEAK. The growth inhibitory activity observed following TweakR stimulation in certain cancer cell lines and the overexpression of TweakR in many solid tumor
Externí odkaz:
https://doaj.org/article/2743f432050840d09fe948a8877e8326
Autor:
Debra T. Chao, Eric D. Hsi, Susan E. Morgan-Lappe, Kurt Gish, Diane Hollenbaugh, Sasmita Mishra, Joann P. Palma, Dong Zhang, Josue Samayoa, Subashri Kumar, Thomas McGonigal, Kelly Foster, Rick Powers, Tamar Uziel, Lisa Durkin, Mien Sho, Melvin Fox, Jonathan Hickson, Sonia G. Tanlimco, James W. Purcell
Cross species binding and tolerability of ABBV-085.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982f60403077744d5cfc6fa3a2c003e3
https://doi.org/10.1158/0008-5472.22419597.v1
https://doi.org/10.1158/0008-5472.22419597.v1
Autor:
Victor M. Villalobos, Anthony Tolcher, James P. Allison, Padmanee Sharma, Randy Robinson, James W. Purcell, Akshanth R. Polepally, Huibin Yue, Dominic W. Lai, Hua Fang, Chris Chen, Louie Naumovski, Vivek Subbiah, Alexander I. Spira, John D. Powderly, Antoine Hollebecque, Jason J. Luke, George D. Demetri
Supplementary Table S2 shows LRRC15 IHC expression in tumor and stroma of patients with sarcoma treated ABBV-085 monotherapy at 3.6 or 4.2 mg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2759a945219be6472c0fcb49ad3fe7
https://doi.org/10.1158/1078-0432.22479056.v1
https://doi.org/10.1158/1078-0432.22479056.v1
Autor:
Debra T. Chao, Eric D. Hsi, Susan E. Morgan-Lappe, Kurt Gish, Diane Hollenbaugh, Sasmita Mishra, Joann P. Palma, Dong Zhang, Josue Samayoa, Subashri Kumar, Thomas McGonigal, Kelly Foster, Rick Powers, Tamar Uziel, Lisa Durkin, Mien Sho, Melvin Fox, Jonathan Hickson, Sonia G. Tanlimco, James W. Purcell
Figures S1-S7 show LRRC15 RNA and protein expression in cancer, and demonstrate the anti-tumor efficacy of the LRRC15-targeted ADC ABBV-085 in vitro and in vivo as a monotherapy and in combination with standard-of-care therapies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce87f6ad600e2154e056d843f01435f
https://doi.org/10.1158/0008-5472.22419600.v1
https://doi.org/10.1158/0008-5472.22419600.v1
Autor:
Viji Shridhar, Anirban K. Mitra, Nagarajan Kannan, Scott H. Kaufmann, Jamie N. Bakkum-Gamez, James W. Purcell, Xiaonan Hou, S. John Weroha, Bhaskar Roy, Debarshi Roy, Julie K. Staub, Prabhu Thirusangu, Sayantani Sarkar Bhattacharya, Subramanyam Dasari, Yinan Xiao, Ling Jin, Deok-Beom Jung, Upasana Ray
Dissemination of ovarian cancer cells can lead to inoperable metastatic lesions in the bowel and omentum that cause patient death. Here we show that LRRC15, a type-I 15-leucine–rich repeat-containing membrane protein, highly overexpressed in ovaria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2762054a1279e40777a463a4112c3b6b
https://doi.org/10.1158/0008-5472.c.6513550.v1
https://doi.org/10.1158/0008-5472.c.6513550.v1
Autor:
Victor M. Villalobos, Anthony Tolcher, James P. Allison, Padmanee Sharma, Randy Robinson, James W. Purcell, Akshanth R. Polepally, Huibin Yue, Dominic W. Lai, Hua Fang, Chris Chen, Louie Naumovski, Vivek Subbiah, Alexander I. Spira, John D. Powderly, Antoine Hollebecque, Jason J. Luke, George D. Demetri
Supplementary Figure S1 shows the study design.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f740555983e19b1c823b9f0c6228f7
https://doi.org/10.1158/1078-0432.22479068.v1
https://doi.org/10.1158/1078-0432.22479068.v1
Autor:
Debra T. Chao, Eric D. Hsi, Susan E. Morgan-Lappe, Kurt Gish, Diane Hollenbaugh, Sasmita Mishra, Joann P. Palma, Dong Zhang, Josue Samayoa, Subashri Kumar, Thomas McGonigal, Kelly Foster, Rick Powers, Tamar Uziel, Lisa Durkin, Mien Sho, Melvin Fox, Jonathan Hickson, Sonia G. Tanlimco, James W. Purcell
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f7114cc02667b3ee4fbd00640ed730
https://doi.org/10.1158/0008-5472.22419603.v1
https://doi.org/10.1158/0008-5472.22419603.v1
Autor:
Viji Shridhar, Anirban K. Mitra, Nagarajan Kannan, Scott H. Kaufmann, Jamie N. Bakkum-Gamez, James W. Purcell, Xiaonan Hou, S. John Weroha, Bhaskar Roy, Debarshi Roy, Julie K. Staub, Prabhu Thirusangu, Sayantani Sarkar Bhattacharya, Subramanyam Dasari, Yinan Xiao, Ling Jin, Deok-Beom Jung, Upasana Ray
Supplementary Data from Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68910d3e0504c6863b8cac86e24ae5cd
https://doi.org/10.1158/0008-5472.22430101.v1
https://doi.org/10.1158/0008-5472.22430101.v1
Autor:
Debra T. Chao, Eric D. Hsi, Susan E. Morgan-Lappe, Kurt Gish, Diane Hollenbaugh, Sasmita Mishra, Joann P. Palma, Dong Zhang, Josue Samayoa, Subashri Kumar, Thomas McGonigal, Kelly Foster, Rick Powers, Tamar Uziel, Lisa Durkin, Mien Sho, Melvin Fox, Jonathan Hickson, Sonia G. Tanlimco, James W. Purcell
Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type–specific protein markers. Using RNA expression profiling, we identified t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::168fcc869a754f376a07852c3cd840d9
https://doi.org/10.1158/0008-5472.c.6510423.v1
https://doi.org/10.1158/0008-5472.c.6510423.v1
Autor:
Upasana Ray, Christopher L. Pathoulas, Prabhu Thirusangu, James W. Purcell, Nagarajan Kannan, Viji Shridhar
Publikováno v:
Cancer Res
Abundant fibrotic stroma is a typical feature of most solid tumors, and stromal activation promotes oncogenesis, therapy resistance, and metastatic dissemination of cancer cells. Therefore, targeting the tumor stroma in combination with standard-of-c