Zobrazeno 1 - 10
of 59
pro vyhledávání: '"James W. Perfield"'
Autor:
Patrick J. Antonellis, Brian A. Droz, Richard Cosgrove, Libbey S. O'Farrell, Tamer Coskun, James W. Perfield, II, Steven Bauer, Mark Wade, Tara E. Chouinard, Joseph T. Brozinick, Andrew C. Adams, Ricardo J. Samms
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 131-139 (2019)
Objective: Fibroblast growth factor 19 (FGF19) is a postprandial hormone which plays diverse roles in the regulation of bile acid, glucose, and lipid metabolism. Administration of FGF19 to obese/diabetic mice lowers body weight, improves insulin sens
Externí odkaz:
https://doaj.org/article/f1ef67a9a6a44312b87faed6aa256893
Autor:
Ricardo J. Samms, Dennis P. Smith, Christine C. Cheng, Patrick P. Antonellis, James W. Perfield 2nd, Alexei Kharitonenkov, Ruth E. Gimeno, Andrew C. Adams
Publikováno v:
Cell Reports, Vol 11, Iss 7, Pp 991-999 (2015)
A primary target of the pleiotropic metabolic hormone FGF21 is adipose tissue, where it initiates a gene expression program to enhance energy expenditure, an effect presumed to be centered on augmented UCP1 expression and activity. In UCP1 null (UCP1
Externí odkaz:
https://doaj.org/article/3d27427d33034b5a8636289a607e3145
Autor:
Hideaki Miyoshi, Sandra C. Souza, Mikiko Endo, Takashi Sawada, James W. Perfield, II, Chikara Shimizu, Zlatina Stancheva, So Nagai, Katherine J. Strissel, Narihito Yoshioka, Martin S. Obin, Takao Koike, Andrew S. Greenberg
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 975-982 (2010)
Perilipin A is the most abundant phosphoprotein on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Perilipin null mice exhibit diminished adipose tissue, elevated basal lipolysis, reduced catecholamine-stimulated lipolysis,
Externí odkaz:
https://doaj.org/article/260e09a5d0af44fcbb53695c2f90c42c
Autor:
Sandra C. Souza, Marcelo A. Christoffolete, Miriam O. Ribeiro, Hideaki Miyoshi, Katherine J. Strissel, Zlatina S. Stancheva, Nicole H. Rogers, Tara M. D'Eon, James W. Perfield, II, Hitomi Imachi, Martin S. Obin, Antonio C. Bianco, Andrew S. Greenberg
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1273-1279 (2007)
In response to cold, norepinephrine (NE)-induced triacylglycerol hydrolysis (lipolysis) in adipocytes of brown adipose tissue (BAT) provides fatty acid substrates to mitochondria for heat generation (adaptive thermogenesis). NE-induced lipolysis is m
Externí odkaz:
https://doaj.org/article/acf6a4bb370d4311994c2d085ee15e66
Autor:
James W. Perfield, Laura C. Ortinau, R. Taylor Pickering, Meghan L. Ruebel, Grace M. Meers, R. Scott Rector
Publikováno v:
Journal of Obesity, Vol 2013 (2013)
Nonalcoholic fatty liver disease (NAFLD) is strongly linked to obesity, insulin resistance, and abnormal hepatic lipid metabolism; however, the precise regulation of these processes remains poorly understood. Here we examined genes and proteins invol
Externí odkaz:
https://doaj.org/article/dfd04a80b8ba4c819ca06bb83bc95b6c
Autor:
Sarah J. Borengasser, R. Scott Rector, Grace M. Uptergrove, E. Matthew Morris, James W. Perfield, Frank W. Booth, Kevin L. Fritsche, Jamal A. Ibdah, John P. Thyfault
Publikováno v:
Journal of Nutrition and Metabolism, Vol 2012 (2012)
Background and Aims. This study examined if exercise and omega-3 fatty acid (n3PUFA) supplementation is an effective treatment for hepatic steatosis in obese, hyperphagic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Methods. Male OLETF rats were d
Externí odkaz:
https://doaj.org/article/f2385f7d1d2f4563b700f9c8e97644fc
Autor:
Takashi Sawada, Hideaki Miyoshi, Kohei Shimada, Akira Suzuki, Yuko Okamatsu-Ogura, James W. Perfield, Takuma Kondo, So Nagai, Chikara Shimizu, Narihito Yoshioka, Andrew S. Greenberg, Kazuhiro Kimura, Takao Koike
Publikováno v:
PLoS ONE, Vol 5, Iss 11 (2010)
Externí odkaz:
https://doaj.org/article/ba05fb158568443183f81915bbce6780
Autor:
Cassandra L. Lamb, Sarah L. Giesy, Molly M. McGuckin, James W. Perfield, Anthony Butterfield, Mohammed Moniruzzaman, Norman J. Haughey, Joseph W. McFadden, Yves R. Boisclair
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
During metabolically demanding physiological states, ruminants and other mammals coordinate nutrient use among tissues by varying the set point of insulin action. This set point is regulated in part by metabolic hormones with some antagonizing (e.g.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db16cf229a60f757a6750a77b5539888
https://doi.org/10.1152/ajpregu.00259.2021
https://doi.org/10.1152/ajpregu.00259.2021
Autor:
Ryan D. Sheldon, E. Matthew Morris, Anthony M. Butterfield, John P. Thyfault, Melissa A. Linden, R. Scott Rector, Grace M. Meers, James W. Perfield, Justin A. Fletcher
Publikováno v:
Experimental Physiology. 103:408-418
NEW FINDINGS What is the central question of this study? Does a reduction in hepatic peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), which has been observed in an insulin-resistant obese state, impair the ability of fibroblas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51a58b3787a4034587a4eaf6db29a80b
https://doi.org/10.1113/ep086629
https://doi.org/10.1113/ep086629
Autor:
Melissa A. Linden, Matthew R. Panasevich, Sree V. Chintapalli, Jamal A. Ibdah, Umesh D. Wankhade, Frank W. Booth, Grace M. Meers, R. S. Rector, Kevin L. Fritsche, Kartik Shankar, James W. Perfield
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 314:E78-E92
Pediatric obesity and nonalcoholic steatohepatitis (NASH) are on the rise in industrialized countries, yet our ability to mechanistically examine this relationship is limited by the lack of a suitable higher animal models. Here, we examined the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1719059741f273b86df440062ee03e3d
https://doi.org/10.1152/ajpendo.00015.2017
https://doi.org/10.1152/ajpendo.00015.2017