Zobrazeno 1 - 10
of 11
pro vyhledávání: '"James W. Mockridge"'
Publikováno v:
Biochemical and Biophysical Research Communications. 286:995-1002
Protein kinase C (PKC)-mediated regulation of the mitogen-activated protein kinases (MAPK) may play a role in the protection afforded by ischemic preconditioning (PC). Nitric oxide (NO) can influence MAPK activation via interaction with PKC or farnes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931e286c8ee05163811354ce984fb83b
https://doi.org/10.1006/bbrc.2001.5477
https://doi.org/10.1006/bbrc.2001.5477
Publikováno v:
Biochemical Journal. 350:891-899
Delayed cytoprotection (preconditioning) occurs 24h after sublethal simulated ischaemia and reperfusion (SI/R) in neonatal rat ventricular cardiomyocytes. SI/R was used to investigate the role of activation of mitogen-activated protein kinases (MA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::251d695f2c312718f166a19d6f7f717d
https://doi.org/10.1042/bj3500891
https://doi.org/10.1042/bj3500891
Publikováno v:
Livestock Production Science. 55:1-11
The growth hormone (GH)-enhancing monoclonal antibody (MAb) OA15 defines a functionally linear epitope (residues 91–102) lying on the loop connecting helices 2 and 3 of the bovine GH (bGH) molecule. Further studies revealed that a number of analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd57db229d8793c6b456baa3033a0a1
https://doi.org/10.1016/s0301-6226(98)00128-6
https://doi.org/10.1016/s0301-6226(98)00128-6
Autor:
Neville S. Huskisson, Christopher Plumpton, James W. Mockridge, Anthony P. Davenport, Rhoda E. Kuc, Patrick J. Barker
Publikováno v:
The Histochemical Journal. 30:359-374
Our aim was to determine whether the expression of endothelin-converting enzyme in human tissues would correlate with the distribution of its substrate, big endothelin-1, and its product, the mature peptide. Site-directed antisera raised against the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de6df831569d05172d2cc48cfa64a980
https://doi.org/10.1023/a:1003236628701
https://doi.org/10.1023/a:1003236628701
Publikováno v:
British Journal of Pharmacology. 122:1647-1654
1 We have characterized the human smooth muscle endothelin converting enzyme (ECE) present in the media of the endothelium-denuded human umbilical vein preparation. 2 Endothelin-1 (ET-1) and ET-2 were potent constrictors of umbilical vein with EC50 v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd5a1d016bc114229ff87fbe24ae1ef7
https://doi.org/10.1038/sj.bjp.0701564
https://doi.org/10.1038/sj.bjp.0701564
Autor:
Michael S. Marber, Yibin Wang, James W. Mockridge, Jody L. Martin, Claire Foley, Richard J. Heads, Adrian T. Saurin, Matthew Wright
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 14(14)
Activation of protein kinase C (PKC) and more recently mitogen-activated protein kinases (MAPKs) have been associated with the cardioprotective effect of ischemic preconditioning. We examined the interplay between these kinases in a characterized mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599417d10d4887ebbbc5e9067bcfbadf
https://pubmed.ncbi.nlm.nih.gov/11053245
https://pubmed.ncbi.nlm.nih.gov/11053245
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 279(2)
In this study we used an in vitro model of delayed preconditioning to investigate activation of mitogen-activated protein kinases (MAPKs) and their potential role in protection. Neonatal rat cardiomyocytes were preconditioned using a buffer containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e0c132a235d8e4cfab1fec9bd80b18
https://pubmed.ncbi.nlm.nih.gov/10924046
https://pubmed.ncbi.nlm.nih.gov/10924046
Autor:
James W. Mockridge, Michael S. Marber, David S. Latchman, Richard J. Heads, Larisa V. Andreeva, Eleanor C. Benton
Publikováno v:
Biochemical and biophysical research communications. 273(1)
In this study we have determined the ability of IGF-1 to protect cardiac fibroblasts against osmotic-induced apoptosis and investigated the potential mechanism(s) underlying this protection. Treatment with IGF-1 (1–100 ng/ml) promoted a dose depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31940c0a6232ccaf86c18237133b7614
https://pubmed.ncbi.nlm.nih.gov/10873605
https://pubmed.ncbi.nlm.nih.gov/10873605
Autor:
Giovanni E. Mann, R J Edwards, Roby Rakhit, Anwar R. Baydoun, Amanda W. Wyatt, Michael S. Marber, James W. Mockridge
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 278(4)
The aim of this study was to investigate the role of nitric oxide (NO) in a cellular model of early preconditioning (PC) in cultured neonatal rat ventricular myocytes. Cardiomyocytes “preconditioned” with 90 min of stimulated ischemia (SI) follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f960292e7551ac71cbe38201a81404d
https://pubmed.ncbi.nlm.nih.gov/10749716
https://pubmed.ncbi.nlm.nih.gov/10749716
Publikováno v:
European journal of endocrinology. 138(4)
In this study we have investigated the effect on the bioactivity of pituitary-derived human growth hormone (hGH) and recombinant bovine (b) GH after the addition of various concentrations of the water soluble cross-linking agent 1-ethyl-3(3-dimethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b74fecbc065847ff10634ec22aaee2c
https://pubmed.ncbi.nlm.nih.gov/9578516
https://pubmed.ncbi.nlm.nih.gov/9578516