Zobrazeno 1 - 10
of 176
pro vyhledávání: '"James W. McGinity"'
Autor:
Justin S. LaFountaine, Robert O. Williams, Leena Kumari Prasad, Dave A. Miller, James W. McGinity
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 113:157-167
The oral delivery of mucoadhesive patches has been shown to enhance the absorption of large molecules such as peptides. We hypothesized that this mechanism could have utility for poorly soluble small molecules by utilizing a mucoadhesive polymer as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dec0179f5ed397fadfa5decc4ea441
https://doi.org/10.1016/j.ejpb.2016.12.031
https://doi.org/10.1016/j.ejpb.2016.12.031
Autor:
Robert O. Williams, Julien Maincent, Justin M. Keen, Leena Kumari Prasad, Justin S. LaFountaine, James W. McGinity
Publikováno v:
Journal of Drug Delivery Science and Technology. 30:501-510
An electrostatic powder deposition (ESPD) method was developed to prepare free films for drug delivery. Films were prepared using polyethylene oxide (PEO), a physical mixture of PEO and acetaminophen (APAP), and co-processed PEO and APAP particles. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344d05f947af72304565063d1d51347e
https://doi.org/10.1016/j.jddst.2015.08.011
https://doi.org/10.1016/j.jddst.2015.08.011
Autor:
Dave A. Miller, Robert O. Williams, Chris Brough, Justin S. LaFountaine, James W. McGinity, Leena Kumari Prasad
Publikováno v:
AAPS PharmSciTech. 17:120-132
Thermal processing technologies continue to gain interest in pharmaceutical manufacturing. However, the types and grades of polymers that can be utilized in common thermal processing technologies, such as hot-melt extrusion (HME), are often limited b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acaea5458cf345093df9aad4fb8a09b9
https://doi.org/10.1208/s12249-015-0417-7
https://doi.org/10.1208/s12249-015-0417-7
Autor:
Justin M. Keen, Daniel J. Ellenberger, Dave A. Miller, James W. McGinity, Robert O. Williams, Chris Brough, Marshall Cisneros
Publikováno v:
Journal of Pharmacy and Pharmacology. 68:678-691
Objectives To evaluate the effect of ritonavir (RTV) co-administration on the bioavailability of an amorphous dispersion of acetyl-11-keto-beta-boswellic acid (AKBA) and to develop a pharmaceutically acceptable AKBA–RTV combination tablet. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e40a336fda0f91b62a489c2e29672b
https://doi.org/10.1111/jphp.12478
https://doi.org/10.1111/jphp.12478
Autor:
Mark A. Rickard, Siyuan Huang, Justin M. Keen, Kevin P. O’Donnell, James W. McGinity, Robert O. Williams
Publikováno v:
AAPS PharmSciTech. 17:106-119
Hypromellose is a hydrophilic polymer widely used in immediate- and modified-release oral pharmaceutical dosage forms. However, currently available grades of hypromellose are difficult, if not impossible, to process by hot melt extrusion (HME) becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10442536f6a294ad118eddd0be94c5de
https://doi.org/10.1208/s12249-015-0395-9
https://doi.org/10.1208/s12249-015-0395-9
Publikováno v:
AAPS PharmSciTech. 17:43-55
Thermal processing of amorphous solid dispersions continues to gain interest in the pharmaceutical industry, as evident by several recently approved commercial products. Still, a number of pharmaceutical polymer carriers exhibit thermal or viscoelast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9172c2bf6c4be5324d1d500a48eee4e
https://doi.org/10.1208/s12249-015-0393-y
https://doi.org/10.1208/s12249-015-0393-y
Autor:
Justin M. Keen, James W. McGinity, Justin R. Hughey, Vincent Jannin, Ryan C. Bennett, Connor J. Foley, Yvonne Rosiaux, Delphine Marchaud
Publikováno v:
International Journal of Pharmaceutics. 487:72-80
Interest in granulation processes using twin screw extrusion machines is rapidly growing. The primary objectives of this study were to develop a continuous granulation process for direct production of granules using this technique with glyceryl behen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6174d0a71595d6fb131e6e4e3e15853
https://doi.org/10.1016/j.ijpharm.2015.03.058
https://doi.org/10.1016/j.ijpharm.2015.03.058
Publikováno v:
Drug Development and Industrial Pharmacy. 41:1294-1301
While the use of amorphous solid dispersions to improve aqueous solubility is well documented, little consideration has traditionally been given to the finished dosage form. The objective of this study was to evaluate the dissolution performance of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504685025a2ae169c14b6cd0dd62d6ef
https://doi.org/10.3109/03639045.2014.947508
https://doi.org/10.3109/03639045.2014.947508
Publikováno v:
Drug Development and Industrial Pharmacy. 40:1133-1155
Originally adapted from the plastics industry, the use of hot-melt extrusion has gained favor in drug delivery applications both in academia and the pharmaceutical industry. Several commercial products made by hot-melt extrusion have been approved by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73bc076a89d0e6272d8510210fbdf0c
https://doi.org/10.3109/03639045.2013.838577
https://doi.org/10.3109/03639045.2013.838577
Publikováno v:
Molecular Pharmaceutics. 11:186-196
We investigated the effects of the hot-melt extrusion (HME) process on the properties of itraconazole (ITZ) amorphous solid dispersions made by thin film freezing (TFF) technology. The ITZ-HPMCAS L (1:2) TFF composition exhibited limited drug release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f374263c2f6906ea6212ae12120364b3
https://doi.org/10.1021/mp4003706
https://doi.org/10.1021/mp4003706