Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James W. Mandell"'
Autor:
Zhongqiu Xie, Pawel Ł. Janczyk, Ying Zhang, Aiqun Liu, Xinrui Shi, Sandeep Singh, Loryn Facemire, Kristopher Kubow, Zi Li, Yuemeng Jia, Dorothy Schafer, James W. Mandell, Roger Abounader, Hui Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Genes that modulate the cytoskeleton have been associated with increased cell proliferation and migration. Here, the authors show that AVIL, an actin regulatory protein, is overexpressed in glioblastomas and mediates oncogenic effects through regulat
Externí odkaz:
https://doaj.org/article/03c59fd5f35148edbce45f1cfce5d926
Autor:
Merci N. Best, Yunu Lim, Nina N. Ferenc, Nayoung Kim, Lia Min, Dora Bigler Wang, Kamyar Sharifi, Anna E. Wasserman, Sloane A. McTavish, Karsten H. Siller, Marieke K. Jones, Paul M. Jenkins, James W. Mandell, George S. Bloom
Publikováno v:
Journal of Alzheimer's Disease. :1-17
Background: In Alzheimer’s disease (AD) brain, neuronal polarity and synaptic connectivity are compromised. A key structure for regulating polarity and functions of neurons is the axon initial segment (AIS), which segregates somatodendritic from ax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57c51a31c705c4eed0b2c27031690427
https://doi.org/10.3233/jad-221284
https://doi.org/10.3233/jad-221284
Autor:
Xuehan Sun, Guillermo Eastman, Yu Shi, Subhi Saibaba, Ana K. Oliveira, John R. Lukens, Andrés Norambuena, James W. Mandell, George S. Bloom
INTRODUCTIONNeuronal nuclei are normally smoothly surfaced. In Alzheimer’s disease (AD) and other tauopathies, though, they often develop invaginations. We investigated mechanisms and functional consequences of neuronal nuclear invagination in tauo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6f8d70c75c33989289d853aa6e29b36
https://doi.org/10.1101/2023.05.08.539873
https://doi.org/10.1101/2023.05.08.539873
Publikováno v:
Alzheimer's & Dementia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::931a492c0d8890d789015a85685f81ed
https://doi.org/10.1002/alz.12892
https://doi.org/10.1002/alz.12892
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd9d0c7282856f3b193af88c386c0d4
https://doi.org/10.1002/alz.066169
https://doi.org/10.1002/alz.066169
Autor:
Zhongqiu Xie, Pawel L. Janczyk, Xinrui Shi, Qiong Wang, Sandeep Singh, Robert Cornelison, Jingjing Xu, James W. Mandell, Frederic G. Barr, Hui Li
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Rhabdomyosarcoma (RMS) is a common pediatric soft-tissue cancer. There are two main subtypes driven by distinct mechanisms. Currently, there is no targeted therapy for the disease. We found an oncogene AVIL, whose activity is often abnor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d06dd2128e07ba65e60f69c53f3a4c4a
https://doi.org/10.1073/pnas.2118048119
https://doi.org/10.1073/pnas.2118048119
IntroductionTau phosphorylation at T217 is a promising AD biomarker, but its functional consequences were unknown.MethodsHuman brain and cultured mouse neurons were analyzed by immunoblotting and immunofluorescence for total tau, taupT217, taupT181,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29e91db2e8139a8196de83af3ca09b1f
https://doi.org/10.1101/2022.04.18.488657
https://doi.org/10.1101/2022.04.18.488657
Autor:
Jennifer D Sokolowski, Chloe N Chabanon-Hicks, Claudia Z Han, Daniel S Heffron, James W Mandell
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Apoptotic neurons generated during normal brain development or secondary to pathologic insults are efficiently cleared from the central nervous system. Several soluble factors, including nucleotides, cytokines, and chemokines are released from injure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31a747712dbdd5531141e0f32d70b14
Publikováno v:
Journal of neurosurgery. Spine. 15(3)
The authors report the case of a patient with an intraosseous spinal arteriovenous malformation (AVM) presenting as an epidural mass lesion that was causing spinal cord compression. The 59-year-old woman had bilateral numbness, weakness, and hyperref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a10f77a0f21b93c12d9642776506e8b
https://pubmed.ncbi.nlm.nih.gov/21663404
https://pubmed.ncbi.nlm.nih.gov/21663404
Publikováno v:
Brain Pathol
A diagnostic difficulty in neuropathology practice is distinguishing reactive from neoplastic astrocyte populations. This is particularly true in small biopsy samples that lack evidence of increased cellularity or mitotic activity, microvascular prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::894350d244c2aab3078cc11913fc427a
https://pubmed.ncbi.nlm.nih.gov/20576027
https://pubmed.ncbi.nlm.nih.gov/20576027