Zobrazeno 1 - 10
of 21
pro vyhledávání: '"James W. Malecha"'
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Fig. S1 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0239cd0b9e59719d73ad9a95a451c7a2
https://doi.org/10.1158/1535-7163.22485309
https://doi.org/10.1158/1535-7163.22485309
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Table S1 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad2d0b912497ade790e8191dc8a1a6a
https://doi.org/10.1158/1535-7163.22485300
https://doi.org/10.1158/1535-7163.22485300
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Fig. S2 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a60f07e9e7e82703e95fa9acf75dbf
https://doi.org/10.1158/1535-7163.22485306.v1
https://doi.org/10.1158/1535-7163.22485306.v1
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Methods from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14bc54c95af4c3db718bbfdaab0ab55
https://doi.org/10.1158/1535-7163.22485303.v1
https://doi.org/10.1158/1535-7163.22485303.v1
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Histone deacetylase (HDAC) inhibitors have garnered significant attention as cancer drugs. These therapeutic agents have recently been clinically validated with the market approval of vorinostat (SAHA, Zolinza) for treatment of cutaneous T-cell lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1f183e54b1bbd2454f1a4fe5e3e9de
https://doi.org/10.1158/1535-7163.c.6531885.v1
https://doi.org/10.1158/1535-7163.c.6531885.v1
Autor:
James W. Malecha, Christina N. Steininger, Melanie L. Williams, Kristen E. Shannon, Thomas Rogers, Bryan H. Landis, Tiffany Duffin, Srinivasan Nagarajan, Pegg Jodi Ann, Hwang-Fun Lu, Rico Joseph G, Maureen A. Nickols, Jun Zhu, Sandra K. Freeman, V. Wayne Engleman, David W. Griggs, G. Alan Nickols, Jeffery L. Keene, Devadas Balekudru, Debra M. Meyer, Marisa M. Westlin, Larry Miller, Laura D. Marrufo, Nawasa F. Green, Melissa K. Lantz, Mark A. Russell, Peter G. Ruminski, Mary Beth Finn, H. Peter Kleine, Joe T. Collins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3783-3800
The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d38d74f8d90c225cd3716f76ef91f6
https://doi.org/10.1016/j.bmc.2007.03.034
https://doi.org/10.1016/j.bmc.2007.03.034
Autor:
Walter G. Smith, Suzanne H Kim, Doreen Villani-Price, Matthew W Mahoney, Nayereh S Ghoreishi-Haack, Helen Y. Chen, Thomas D. Penning, Stella Siu-Tzyy Yu, James W. Malecha, Leslie J Askonas, Chi-Dean Liang, Elizabeth I Harding, E.Yvonne Pyla, Maureen K Highkin, James K. Gierse, Julie M Miyashiro, Mark A Russell, James F Kachur, Chen Barbara B
Publikováno v:
Journal of Medicinal Chemistry. 45:3482-3490
Leukotriene B(4) (LTB(4)) is a potent, proinflammatory mediator involved in the pathogenesis of a number of diseases including inflammatory bowel disease, psoriasis, rheumatoid arthritis, and asthma. The enzyme LTA(4) hydrolase represents an attracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49aaaeb42023ad7fd78de02ecc724a97
https://doi.org/10.1021/jm0200916
https://doi.org/10.1021/jm0200916
Autor:
James A. Hendrix, Shun ichiro Hachiya, Kiyoshi Horita, Anthony G. M. Barrett, James W. Malecha, Andrew Vansickle, Oren P. Anderson, Christopher J. Parkinson, Jeremy J. Edmunds
Publikováno v:
Canadian Journal of Chemistry. 79:1562-1592
The formal total synthesis of the marine metabolite (+)-calyculin A is reported. The key steps involve (i) the use of Brown allylboration chemistry to control the relative and absolute stereochemistry of homoallylic alcohol arrays, thus setting eight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36cb1762a5b5724817206219fa2386cd
https://doi.org/10.1139/v01-133
https://doi.org/10.1139/v01-133
Autor:
Doreen Villani-Price, Suzanne H Kim, Walter G. Smith, Leslie J Askonas, Elizabeth I Harding, Maureen K Highkin, Thomas D. Penning, Alan F. Gasiecki, Nayereh S Ghoreishi-Haack, Nizal S Chandrakumar, E.Yvonne Pyla, Bipin N Desai, James F Kachur, Mark A Russell, Stevan W Djuric, James W. Malecha, James K. Gierse, Julie M Miyashiro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1137-1139
The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA(4) hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830ee52b64cb2d30d9d134d0185d9a9
https://doi.org/10.1016/s0960-894x(03)00039-8
https://doi.org/10.1016/s0960-894x(03)00039-8
Autor:
Jeremy J. Edmunds, Anthony G. M. Barrett, James A. Hendrix, Christopher J. Parkinson, James W. Malecha
Publikováno v:
ChemInform. 23
(–)-B-[3-(Diisopropylaminodimethylsilyl)allyl]diisopinocampheylborane and Cornforth–Meyers chemistry, and Evans alkylation were employed to construct the C(26)–C(37) amide–oxazole unit of calyculin A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ef4819ba266a4a945e2bf4f0a60356
https://doi.org/10.1002/chin.199249288
https://doi.org/10.1002/chin.199249288