Temporal and regional regulation of gene expression by calcium-stimulated adenylyl cyclase activity during fear memory.

Autor: Lindsay Wieczorek, James W Maas, Lisa M Muglia, Sherri K Vogt, Louis J Muglia

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13385 (2010)

The Ca2+-stimulated adenylyl cyclases (ACs), AC1 and AC8, are key components of long-term memory processing. AC1 and AC8 double knockout mice (Adcy1(-/-)Adcy8(-/-); DKO) display impaired fear memory processing; the mechanism of this impairment is lar

Externí odkaz: https://doaj.org/article/87fe9021367d47da978215dc936a84b1

Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons

Autor: Robert H. Edwards, James W. Maas, Jing Yang

Publikováno v: Frontiers in Synaptic Neuroscience

Dominant mutations in leucine-rich repeat kinase 2 (LRRK2) produce the most common inherited form of Parkinson's disease (PD) but the function of LRRK2 remains poorly understood. The presynaptic role of multiple genes linked to PD including α-synucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f82a82b641f898ffcecd9fe65d88723

Mutations in the Gene PRRT2 Cause Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsions

Autor: James W. Maas, Michiko K. Bruno, Steve Frucht, Susan B. Bressman, Henry Houlden, Jacques Rochette, Ewout R. Brunt, Ying-Hui Fu, Mark Hermann, Michael G. Hanna, Christina A. Gurnett, Hsien Yang Lee, Kailash P. Bhatia, Shehla Mohammed, Roberto Caraballo, Joseph Jankovic, Mark Nespeca, Ulrich Müller, Kathryn J. Swoboda, Betül Baykan, Pierre Szepetowski, Sam Tucker, Yong Huang, Wei Ling Lee, Natalio Fejerman, David Renner, Robert H. Edwards, Nadine Bruneau, Bing-Wen Soong, Shinji Saiki, Emily Quinn, Elisha D.O. Roberson, Bernard Echenne, Anne M. Bowcock, Edouard Hirsch, Nicholas W. Wood, Gabrielle Rudolf, Louis J. Ptáček, David A. Lynch, Tetsuo Ashizawa, Patrice Roll

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2012, 1 (1), pp.2-12. ⟨10.1016/j.celrep.2011.11.001⟩
Cell reports, vol 1, iss 1
Cell Reports, Vol 1, Iss 1, Pp 2-12 (2012)
Cell reports, 1(1), 2-12. CELL PRESS

Paroxysmal kinesigenic dyskinesia with infantile convulsions (PKD/IC) is an episodic movement disorder with autosomal-dominant inheritance and high penetrance, but the causative genetic mutation is unknown. We have now identified four truncating muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c80ff62525befaab6cbf2e845b361b
https://hdl.handle.net/11370/04f13b66-6c74-41e6-9842-fc9760886251

Calcium-Stimulated Adenylyl Cyclases Modulate Ethanol-Induced Neurodegeneration in the Neonatal Brain

Autor: Amanda A. Shute, Lisa M. Muglia, Sherri K. Vogt, Tim West, John W. Olney, Ricardo A. Indacochea, David M. Holtzman, Steven Mennerick, Ann Benz, Timothy T. Tran, Louis J. Muglia, James W. Maas

Publikováno v: The Journal of Neuroscience. 25:2376-2385

Fetal alcohol exposure results in cognitive and neurobehavioral deficits, but the effects of modifying genetic loci on the severity of these sequelas have not been well characterized. Although the cAMP signaling pathway has been shown to be an import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69a53127280fb260e4a2d4cc7ab3a2d
https://doi.org/10.1523/jneurosci.4940-04.2005

Drug-Induced Actions on Brain Neurotransmitter Systems and Changes in the Behaviors and Emotions of Depressed Patients

Autor: Alan Swann, Stephen H. Koslow, Nancy Berman, James W. Maas, Peter E. Stokes, Martin M. Katz, Charles L. Bowden, Alan Frazer

Publikováno v: Neuropsychopharmacology. 11:89-100

Despite cumulative evidence that the tricyclic drugs result in significant changes in the functioning of brain serotonergic (5-HT) and nordrenergic (NE) systems, such changes have not been found to be associated with recovery from depression. Based u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a07dd771ccb62c06706ee092c608e1b
https://doi.org/10.1038/npp.1994.38