Zobrazeno 1 - 4
of 4
pro vyhledávání: '"James W. Lord"'
Autor:
Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Björn Häupl, George W. Wright, James D. Phelan, Da Wei Huang, James W. Lord, Callie K. Van Winkle, Xin Yu, Jan Wisniewski, James Q. Wang, Frances A. Tosto, Erin Beck, Kelli Wilson, Crystal McKnight, Jameson Travers, Carleen Klumpp-Thomas, Grace A. Smith, Stefania Pittaluga, Irina Maric, Dickran Kazandjian, Craig J. Thomas, Ryan M. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
RAS mutations are commonly found in multiple myeloma (MM). Here, the authors show that oncogenic RAS mutations activate mTORC1 signalling in MM and combining mTORC1 and MEK/ERK inhibitors synergize to improve survival in preclinical models.
Externí odkaz:
https://doaj.org/article/8c3b0c0252af4d719539d036cf04abe8
Autor:
Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Björn Häupl, George W. Wright, James D. Phelan, Da Wei Huang, James W. Lord, Callie K. Van Winkle, Xin Yu, Jan Wisniewski, James Q. Wang, Frances A. Tosto, Erin Beck, Kelli Wilson, Crystal McKnight, Jameson Travers, Carleen Klumpp-Thomas, Grace A. Smith, Stefania Pittaluga, Irina Maric, Dickran Kazandjian, Craig J. Thomas, Ryan M. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/b9cbaec1f91d41609ecd664007364658
Autor:
Frances A. Tosto, Ping Chen, Dickran Kazandjian, Craig J. Thomas, George E. Wright, Kelli M. Wilson, Thomas Oellerich, James W. Lord, Carleen Klumpp-Thomas, Irina Maric, Grace Smith, Crystal McKnight, Da-Wei Huang, Jan Wisnieski, Xin Yu, Ryan M. Young, Björn Häupl, Michele Ceribelli, Arnold Bolomsky, James Q. Wang, Erin S Beck, Callie K. Van Winkle, Jameson Travers, James D. Phelan, Stefania Pittaluga, Yandan Yang
Publikováno v:
Nature communications. 13(1)
Oncogenic mutations within the RAS pathway are common in multiple myeloma (MM), an incurable malignancy of plasma cells. However, the mechanisms of pathogenic RAS signaling in this disease remain enigmatic and difficult to inhibit therapeutically. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ff65735fce3a50eebd3af3c1317c4c
https://pubmed.ncbi.nlm.nih.gov/36192480
https://pubmed.ncbi.nlm.nih.gov/36192480
Autor:
Katherine T. Nesbit, Amro Hamdoun, Jacob F. Warner, James W Lord, Samantha A Schreiter, Deirdre C. Lyons
Publikováno v:
Genome Biol Evol
The painted urchin Lytechinus pictus is a sea urchin in the family Toxopneustidae and one of several sea urchin species that are routinely used as an experimental research organism. Recently, L. pictus has emerged as a tractable model system for esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24597d7543e8c2ed9ea9d9c5db99512e
https://pubmed.ncbi.nlm.nih.gov/33769486
https://pubmed.ncbi.nlm.nih.gov/33769486