Zobrazeno 1 - 10
of 179
pro vyhledávání: '"James W. Lillard"'
Autor:
Lawrence P. McKinney, Rajesh Singh, I. King Jordan, Sooryanarayana Varambally, Eric B. Dammer, James W. Lillard
Publikováno v:
Onco, Vol 3, Iss 2, Pp 81-95 (2023)
Prostate cancer (PCa) is the second most common cause of cancer death in American men. Metastatic castration-resistant prostate cancer (mCRPC) is the most lethal form of PCa and preferentially metastasizes to the bones through incompletely understood
Externí odkaz:
https://doaj.org/article/cd65680bc0774ea68654fed2b027b775
Autor:
Ti’ara L. Griffen, Fieke W. Hoff, Yihua Qiu, James W. Lillard, Alessandra Ferrajoli, Philip Thompson, Endurance Toro, Kevin Ruiz, Jan Burger, William Wierda, Steven M. Kornblau
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 3, Pp 1-14 (2022)
Abstract Protein expression for 384 total and post-translationally modified proteins was assessed in 871 CLL and MSBL patients and was integrated with clinical data to identify strategies for improving diagnostics and therapy, making this the largest
Externí odkaz:
https://doaj.org/article/db77fb9301b64bc0981763c122e79287
Autor:
Ti’ara L. Griffen, Eric B. Dammer, Courtney D. Dill, Kaylin M. Carey, Corey D. Young, Sha’Kayla K. Nunez, Adaugo Q. Ohandjo, Steven M. Kornblau, James W. Lillard
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract Background Chronic lymphocytic leukemia (CLL) is an indolent heme malignancy characterized by the accumulation of CD5+ CD19+ B cells and episodes of relapse. The biological signaling that influence episodes of relapse in CLL are not fully de
Externí odkaz:
https://doaj.org/article/630fb3c97aa645878fb91ed4de80385a
Publikováno v:
Frontiers in Bioscience-Scholar, Vol 12, Iss 1, Pp 137-160 (2020)
Breast cancer (BrCa) is the most commonly diagnosed cancer and the second leading cause of cancer-related death in women. Alarming increases in the cases quests for more effective treatment of BrCa. As most chemotherapeutic drugs are associated with
Externí odkaz:
https://doaj.org/article/f9787d781a804188b72d78c8a59a32b4
Autor:
Courtney D. Dill, Eric B. Dammer, Ti'ara L. Griffen, Nicholas T. Seyfried, James W. Lillard, Jr.
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102451- (2021)
Summary: We aimed to identify triple-negative breast cancer (TNBC) drivers that regulate survival time as predictive signatures that improve TNBC prognostication. Breast cancer (BrCa) transcriptomic tumor biopsies were analyzed, identifying network c
Externí odkaz:
https://doaj.org/article/d1754814fdaf4fc894b95c476afd8f35
Autor:
Santosh Kumar Singh, Jennifer B. Gordetsky, Sejong Bae, Edward P. Acosta, James W. Lillard, Rajesh Singh
Publikováno v:
Cells, Vol 9, Iss 9, p 1976 (2020)
An abnormality in hedgehog (Hh) signaling has been implicated in the progression of prostate cancer (PCa) to a more aggressive and therapy-resistant disease. Our assessments of human PCa tissues have shown an overexpression of the Hh pathway molecule
Externí odkaz:
https://doaj.org/article/3fb34d388eef48e98475b8c555f3fc45
Publikováno v:
Cancer. 128:3787-3795
Black men are disproportionately affected by prostate cancer (PCa), with earlier presentation, more aggressive disease, and higher mortality rates versus White men. Furthermore, Black men have less access to PCa treatment and experience longer delays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9dd76d7c56442ece7a1e323b0d4217
https://doi.org/10.1002/cncr.34433
https://doi.org/10.1002/cncr.34433
Autor:
Runhua Liu, Lizhong Wang, Xingyi Zhang, James W. Lillard, Wei-Hsiung Yang, Lisa L.H. Nguyen, Changming Lu, Rong-Jun Guo, Shi Wei, Sejong Bae, Dongquan Chen, Chao Wang, Bin Yi, Wei Zhang
Purpose: In prostate cancer cells, there is CD24-dependent inactivation of mutant p53, but the mechanism and its significance remain largely unknown. Here, we validated this observation and explored the therapeutic potential of targeting CD24 in TP53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393f54e2aa8d7edf5e7a842761c5bb7c
https://doi.org/10.1158/1078-0432.c.6524030.v1
https://doi.org/10.1158/1078-0432.c.6524030.v1
Publikováno v:
Nature Biotechnology. 39:1468-1474
A summer pipeline program provides under-represented students from around the United States with exposure and first-hand training to advance their careers in the biotechnology industry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef8ef09926961de5b3a4a38a77015413
https://doi.org/10.1038/s41587-021-01110-3
https://doi.org/10.1038/s41587-021-01110-3
Autor:
Fieke W Hoff, Eveline S. J. M. de Bont, Kevin Ruiz, Endurance Toro, Anneke D. van Dijk, Ti’ara L. Griffen, William G. Wierda, James W. Lillard, Steven M. Kornblau, Peter P. Ruvolo, Jan A. Burger, Yihua Qiu
Publikováno v:
Leukemia, 36. Nature Publishing Group
The chronic lymphocytic leukemia (CLL) armamentarium has evolved significantly, with novel therapies that inhibit Bruton Tyrosine Kinase, PI3K delta and/or the BCL2 protein improving outcomes. Still, the clinical course of CLL patients is highly vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f55451f386f788d770de178b20cc62c
https://doi.org/10.1038/s41375-021-01438-4
https://doi.org/10.1038/s41375-021-01438-4