Zobrazeno 1 - 10
of 22
pro vyhledávání: '"James W. Fairman"'
Autor:
Prem Singh Kaushal, Qun Wan, Chris G. Dealwis, Jianying Kiser, Hai Xu, James W. Fairman, Andrew Zhang, Sanath R. Wijerathna, Md. Faiz Ahmad
Publikováno v:
Pharmaceuticals, Vol 4, Iss 10, Pp 1328-1354 (2011)
Ribonucleotide reductase (RR) is a crucial enzyme in de novo DNA synthesis, where it catalyses the rate determining step of dNTP synthesis. RRs consist of a large subunit called RR1 (α), that contains two allosteric sites and one catalytic site, and
Externí odkaz:
https://doaj.org/article/cc9736ee1fed4dd88e3d13b9070a7567
Autor:
Matthew C Clifton, David M Dranow, Alison Leed, Ben Fulroth, James W Fairman, Jan Abendroth, Kateri A Atkins, Ellen Wallace, Dazhong Fan, Guoping Xu, Z J Ni, Doug Daniels, John Van Drie, Guo Wei, Alex B Burgin, Todd R Golub, Brian K Hubbard, Michael H Serrano-Wu
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125010 (2015)
Crystallization of a maltose-binding protein MCL1 fusion has yielded a robust crystallography platform that generated the first apo MCL1 crystal structure, as well as five ligand-bound structures. The ability to obtain fragment-bound structures advan
Externí odkaz:
https://doaj.org/article/1fecc03a2b9c44169e845be5165ab56e
Autor:
Steve R. Barnes, Stephen Nakazawa-Hewitt, Wesley C. Van Voorhis, Thomas E. Edwards, Donald D. Lorimer, Bart L. Staker, Amy Sullivan, Peter J. Myler, Spencer O. Moen, James W. Fairman
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 71:609-614
The crystal structures of prostaglandin F synthase (PGF) from bothLeishmania majorandTrypanosoma cruziwith and without their cofactor NADP have been determined to resolutions of 2.6 Å forT. cruziPGF, 1.25 Å forT. cruziPGF with NADP, 1.6 Å forL. ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f27519d8642cf09c79e8091485f6ee4
https://doi.org/10.1107/s2053230x15006883
https://doi.org/10.1107/s2053230x15006883
Autor:
Brendan R. D'Souza, James W. Fairman, Ben Fulroth, Michael H Serrano-Wu, Virendar K. Kaushik, Todd R. Golub, Brian K. Hubbard, Guo Wei, Chao Fang, Patrick McCarren, Clementine Feau, Christopher F. Thompson, Yikai Wang, Alison Leed, Matthew C. Clifton, Lili Wang, Michelle Palmer
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1308-1312
A direct binding screen of 100 000 sp(3)-rich molecules identified a single diastereomer of a macrolactam core that binds specifically to myeloid cell leukemia 1 (MCL1). A comprehensive toolbox of biophysical methods was applied to validate the origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d080c36b7976ae4ee5a6e8fb1e1ae1
https://doi.org/10.1021/ml500388q
https://doi.org/10.1021/ml500388q
Autor:
Wei Liu, Travis J. Barnard, James W. Fairman, Nathalie Dautin, Nicholas Noinaj, Damian Wojtowicz, Vadim Cherezov, Susan K. Buchanan, Teresa M. Przytycka, Eshwar Udho
Publikováno v:
Structure. 20(7):1233-1243
SummaryIntimins and invasins are virulence factors produced by pathogenic Gram-negative bacteria. They contain C-terminal extracellular passenger domains that are involved in adhesion to host cells and N-terminal β domains that are embedded in the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49603bc3b17ecdec992fbd8e97787069
Autor:
Shalini Jha, Thomas Walz, A.K. Roos, R Martin Welin, Faiz Ahmad, P. Nordlund, Hai Xu, Sanath R. Wijerathna, Zongli Li, Ryo Nakano, Chris Dealwis, Jay S. Prendergast, James W. Fairman, Susanne Flodin
Publikováno v:
Nature Structural & Molecular Biology. 18:316-322
Ribonucleotide reductase (RR) is an αnβn (RR1●RR2) complex that maintains balanced dNTP pools by reducing ribonucleoside diphosphates to deoxyribonucleoside diphosphates. RR1 is the catalytic subunit and RR2 houses the free radical required for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0341ab9e8f8dd1a61091497344b0296a
https://doi.org/10.1038/nsmb.2007
https://doi.org/10.1038/nsmb.2007
Autor:
Michael J. Herron, LeeAnn Higgins, Timothy J. Kurtti, Ulrike G. Munderloh, Nicole Y. Burkhardt, Curtis M. Nelson, Roderick F. Felsheim, Thomas E. Edwards, Todd W. Markowski, Adela S. Oliva Chávez, Jonathan D. Oliver, James W. Fairman
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 11, Iss 11, p e1005248 (2015)
PLoS Pathogens, Vol 11, Iss 11, p e1005248 (2015)
Anaplasma phagocytophilum, the causative agent of Human Granulocytic Anaplasmosis (HGA), is an obligately intracellular α-proteobacterium that is transmitted by Ixodes spp ticks. However, the pathogen is not transovarially transmitted between tick g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e01d74b96c1a554fde929849113b888
http://europepmc.org/articles/PMC4636158
http://europepmc.org/articles/PMC4636158
Autor:
David M. Dranow, Loren Baugh, David A. Fox, Dmitri Serbzhinskiy, Robin Stacy, Stephen N. Hewitt, Marvin M. Muruthi, Matthew C. Clifton, Ryan Choi, Darren W. Begley, Ngoc Tran, Wesley C. Van Voorhis, Sally Lyons-Abbott, Don Lorimer, Jan Abendroth, Ariel Abramov, Bart L. Staker, Alberto J. Napuli, Katie Thompkins, Brandy M. Taylor, Isabelle Phan, Shellie H. Dieterich, James W. Fairman, Elizabeth Mundt, Yang Zhang, Garry W. Buchko, Aarthi Sekar, Brianna Armour, Lynn K. Barrett, Peter J. Myler, Janette B. Myers, Thomas E. Edwards, Anna Gardberg, Micah Ferrell, Lance Stewart
High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus “homolog-resc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a905313c0a3d901a44a835c7bee631e8
https://europepmc.org/articles/PMC4361283/
https://europepmc.org/articles/PMC4361283/
Autor:
Atashi Anupama, Kenneth Stuart, Thomas E. Edwards, Igor Cestari, Dhanasekaran Shanmugam, Douglas R. Davies, Sergio Schenkman, James W. Fairman, Nilmar Silvio Moretti, Peter J. Myler, Isabelle Phan
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 71(Pt 5)
Prior studies have highlighted the potential of superoxide dismutases as drug targets in eukaryotic pathogens. This report presents the structures of three iron-dependent superoxide dismutases (FeSODs) fromTrypanosoma cruzi,Leishmania majorandBabesia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3df7d3d76329ab2c4c4e1bb18873df
https://pubmed.ncbi.nlm.nih.gov/25961325
https://pubmed.ncbi.nlm.nih.gov/25961325
Autor:
Jennifer L. Kirkwood, Thomas E. Edwards, Amy C. Raymond, Bart L. Staker, Jan Abendroth, James W. Fairman, Spencer O. Moen, Greg Henkel, Robin Stacy, Ken McCormack, Darren W. Begley, Ruth Baydo, Vincent C. Tam, Jameson Bullen, Steve R. Barnes, Isabelle Phan, Don Lorimer, Peter J. Myler
Publikováno v:
Scientific Reports
Influenza A viruses cause the respiratory illness influenza, which can be mild to fatal depending on the strain and host immune response. The flu polymerase acidic (PA), polymerase basic 1 (PB1), and polymerase basic 2 (PB2) proteins comprise the RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd33fc2fe5a018e46acdaec5099c9bb
https://doi.org/10.1038/srep05944
https://doi.org/10.1038/srep05944