Zobrazeno 1 - 10
of 10
pro vyhledávání: '"James W. Darges"'
Autor:
John W. Lampe, Christopher T. Lowden, G. Erik Jagdmann, Frederick R. Hubbard, Hong Hu, Mary George Johnson, Michael Patrick Lynch, Lawrence Michael Ballas, Sean P. Hollinshead, Steven E. Hall, Julia Marie Heerding, Jean Marie Defauw, Jose S. Mendoza, Marcia M. Murphy, Christopher K. Biggers, Joseph W. Wilson, Kiyomi Carter, Robert J. Foglesong, Jefferson E. Davis, Philip F. Hughes, Yen-Shi Lai, Mark L. Stamper, James W. Darges
Publikováno v:
Journal of Medicinal Chemistry. 45:2624-2643
A series of analogues of the protein kinase C (PKC) inhibitory natural product balanol which bear modified benzophenone subunits are described. The analogues were designed with the goal of uncovering structure-activity features that could be used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b848f26ec9d5d2fbf8c1b1cafa0ef593
https://doi.org/10.1021/jm020018f
https://doi.org/10.1021/jm020018f
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1759-1764
Balanol ((−)-1) is a potent protein kinase inhibitory natural product isolated from the fungus Verticillium balanoides. The lack of cellular activity and protein kinase C selectivity in balanol has prompted a search for analogs that incorporate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6c3739ea696811a27a3432ce690c822
https://doi.org/10.1016/0960-894x(96)00311-3
https://doi.org/10.1016/0960-894x(96)00311-3
Autor:
F. R. Hubbard, Hong Hu, Steven E. Hall, James W. Darges, Heerding Jm, M. M. Murphy, J. W. Lampe, John Davis, Defauw Jean Marie, Heidi Crane, Sean P. Hollinshead, J. S. Mendoza, Jagdmann Ge, T. J. Mitchell
Publikováno v:
Journal of Medicinal Chemistry. 39:5215-5227
A series of balanol analogs in which the perhydroazepine ring and the p-hydroxybenzamide moiety were combined into an acyclic linked unit have been prepared and evaluated for their inhibitory properties against the serine/threonine kinase PKC. Severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c7e95bc85f37e145403c3dcb685b72
https://doi.org/10.1021/jm960581w
https://doi.org/10.1021/jm960581w
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2133-2138
As part of an effort to enhance the cellular activity of balanol analogs 2 and 3, we prepared a series of benzophenone ester analogs of varying steric size and hydrolytic stability. These were evaluated for protein kinase C inhibitory activity, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84b3b8ffe4fe9b7666ff10e3260cf2d8
https://doi.org/10.1016/0960-894x(95)00361-v
https://doi.org/10.1016/0960-894x(95)00361-v
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1839-1842
A variety of balanol analogs bearing carboxylic acid replacements (amides, sulfonamides and tetrazoles) were synthesized and evaluated for protein kinase C (PKC) inhibitory activity. In general, those compounds which bear an acidic proton (pKa ≤ 7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69311df84b48fc3b4457ed3ecb02fd6c
https://doi.org/10.1016/0960-894x(95)00303-b
https://doi.org/10.1016/0960-894x(95)00303-b
Autor:
William P. Janzen, Lawrence M. Ballas, James W. Darges, Chang-Qi Hu, Jack B. Jiang, Laurel M. Adams, Jan C. Seldin, Palaniappan Kulanthaivel, Divann J. Cofield
Publikováno v:
Planta Medica. 61:41-44
The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21b0fb74400dd7fba3f2ae91aecbabf2
https://doi.org/10.1055/s-2006-957996
https://doi.org/10.1055/s-2006-957996
Autor:
F. R. Hubbard, M. M. Murphy, John Davis, Steven E. Hall, Defauw Jean Marie, J. W. Lampe, Heidi Crane, Heerding Jm, T. J. Mitchell, J. S. Mendoza, James W. Darges, Sean P. Hollinshead, Hong Hu, G. E. Jun. Jagdmann
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e140433cce4896f4333b40c24351aba
https://doi.org/10.1002/chin.199716274
https://doi.org/10.1002/chin.199716274
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::587390a888a5a6500369a95041f2f4e9
https://doi.org/10.1002/chin.199649261
https://doi.org/10.1002/chin.199649261
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461374305
The sphingosine analog L-threo-dihydrosphingosine has been shown to inhibit protein kinase C (PKC) isoenzymes in mixed micelle and vesicle assays. This compound also inhibited the reactive oxygen intermediates (ROI) released from isolated neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d667b97eded60942379356177dc68f46
https://doi.org/10.1007/978-1-4615-5325-0_52
https://doi.org/10.1007/978-1-4615-5325-0_52
Publikováno v:
Molecular and cellular biochemistry. 141(2)
Transmission of extra cellular signals across biological membranes results in the generation of lipid metabolites which in turn influence specific cellular events such as cell growth or differentiation. Many of these lipid messengers can activate pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d63cd32b13edc44d7eec44d21fd9975
https://pubmed.ncbi.nlm.nih.gov/7891670
https://pubmed.ncbi.nlm.nih.gov/7891670