Zobrazeno 1 - 10
of 14
pro vyhledávání: '"James W. Clendening"'
Autor:
Linda Z. Penn, P. Leif Bergsagel, A. Keith Stewart, Igor Jurisica, Fereshteh Khosravi, Christina Bros, Paul C. Boutros, Anna Martirosyan, James W. Clendening, W. Wei-Lynn Wong
Statins, commonly used to treat hypercholesterolemia, have been shown to trigger tumor-specific apoptosis in certain cancers, including multiple myeloma (MM), a plasma cell malignancy with poor prognosis. In this article, we show that of a panel of 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df62dbf76d9177299476b1da3f0f3b5
https://doi.org/10.1158/1535-7163.c.6532394.v1
https://doi.org/10.1158/1535-7163.c.6532394.v1
Autor:
Linda Z. Penn, P. Leif Bergsagel, A. Keith Stewart, Igor Jurisica, Fereshteh Khosravi, Christina Bros, Paul C. Boutros, Anna Martirosyan, James W. Clendening, W. Wei-Lynn Wong
PDF file - 84 KB, Differentially expressed cells in genes upon exposure to 20 muM lovastatin in resistant MM cell lines (LP1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407403ddd09966408605ef8da4f34bab
https://doi.org/10.1158/1535-7163.22486820
https://doi.org/10.1158/1535-7163.22486820
Autor:
Linda Z. Penn, Cheryl H. Arrowsmith, Igor Jurisica, Robert Kay, Daniel Y.L. Mao, Dalia Barsyte-Lovejoy, Grace A. Trentin, Yi Sheng, James W. Clendening, Paul C. Boutros, Lilia Kaustov, Mary Shago, Sam S. Kim
Using an expression cloning approach, we identify CUL7, a member of the cullin family, as a functional inhibitor of Myc-induced apoptosis. Deregulated expression of the Myc oncogene drives cellular proliferation yet also sensitizes cells to undergo p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ba3d485881e882a5a75bbe4570b6a1
https://doi.org/10.1158/0008-5472.c.6496401
https://doi.org/10.1158/0008-5472.c.6496401
Autor:
Linda Z. Penn, Cheryl H. Arrowsmith, Igor Jurisica, Robert Kay, Daniel Y.L. Mao, Dalia Barsyte-Lovejoy, Grace A. Trentin, Yi Sheng, James W. Clendening, Paul C. Boutros, Lilia Kaustov, Mary Shago, Sam S. Kim
Supplementary Figure Legends 1-5 from CUL7 Is a Novel Antiapoptotic Oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21cd9898416b52162a447acdccf48138
https://doi.org/10.1158/0008-5472.22370439
https://doi.org/10.1158/0008-5472.22370439
Autor:
Stefan Foser, C. Mascaux, Kieran Mace, James W. Clendening, Lisa I. Wang, Luis Paz-Ares, Lukas Bubendorf, Q. Zhang, Adam Gondos, Fabrice Barlesi
Publikováno v:
Journal of Clinical Oncology. 37:9076-9076
9076 Background: The number of targeted txs for NSCLC is increasing. By analyzing numerous molecular alterations, CGP may open more targeted tx options than single biomarker testing. Methods: We analyzed a database linking Flatiron Health electronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b2917a5a60a26800c201d46b001283b
https://doi.org/10.1200/jco.2019.37.15_suppl.9076
https://doi.org/10.1200/jco.2019.37.15_suppl.9076
Autor:
James W. Clendening, Linda Z. Penn
Publikováno v:
Oncogene. 31:4967-4978
The mevalonate pathway is a core biochemical process, crucial for the generation of cholesterol and other key metabolic end products. The rate-limiting enzyme of the mevalonate pathway, hydroxymethylglutaryl coenzyme A reductase (HMGCR), is safely an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30320718bdbbb11300977ab5590e62b
https://doi.org/10.1038/onc.2012.6
https://doi.org/10.1038/onc.2012.6
Autor:
Anna Martirosyan, Razqallah Hakem, Grace Trentin, Fereshteh Khosravi, James W. Clendening, Igor Jurisica, Samah El Ghamrasni, Linda Z. Penn, Aleks Pandyra, Paul C. Boutros, Anne Hakem
Publikováno v:
Proceedings of the National Academy of Sciences. 107:15051-15056
The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood. With a clear understanding of how metabolism contributes to tumorig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af6d34683cf15ad0b316c84fafdfd00
https://doi.org/10.1073/pnas.0910258107
https://doi.org/10.1073/pnas.0910258107
Autor:
Daniel Y.L. Mao, Cheryl H. Arrowsmith, James W. Clendening, Lilia Kaustov, Robert Kay, Paul C. Boutros, Dalia Barsyte-Lovejoy, Linda Z. Penn, Igor Jurisica, Grace Trentin, Mary Shago, Yi Sheng, Sam S. Kim
Publikováno v:
Cancer Research. 67:9616-9622
Using an expression cloning approach, we identify CUL7, a member of the cullin family, as a functional inhibitor of Myc-induced apoptosis. Deregulated expression of the Myc oncogene drives cellular proliferation yet also sensitizes cells to undergo p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcd9a2f477b1c43728783ec2b37ad48
https://doi.org/10.1158/0008-5472.can-07-0644
https://doi.org/10.1158/0008-5472.can-07-0644
Autor:
Linda Z. Penn, Anna Martirosyan, Paul C. Boutros, W. Wei-Lynn Wong, Christina Bros, James W. Clendening, P. Leif Bergsagel, Fereshteh Khosravi, Igor Jurisica, A. Keith Stewart
Publikováno v:
Molecular Cancer Therapeutics. 6:1886-1897
Statins, commonly used to treat hypercholesterolemia, have been shown to trigger tumor-specific apoptosis in certain cancers, including multiple myeloma (MM), a plasma cell malignancy with poor prognosis. In this article, we show that of a panel of 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92361ccee6e5739f1e3a784b802bd5a0
https://doi.org/10.1158/1535-7163.mct-06-0745
https://doi.org/10.1158/1535-7163.mct-06-0745
Autor:
Syed Haider, Linda Z. Penn, Amanda R. Wasylishen, Dorota H. Sendorek, James W. Clendening, Carolyn A. Goard, Paul C. Boutros, Peter J. Mullen, Ariel D. Quiroga, Michelle Chan-Seng-Yue, Richard Lehner
Statins, routinely used to treat hypercholesterolemia, selectively induce apoptosis in some tumor cells by inhibiting the mevalonate pathway. Recent clinical studies suggest that a subset of breast tumors is particularly susceptible to lipophilic sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304c3aa3aa7e69238961608402edf029
http://link.springer.com/article/10.1007/s10549-013-2800-y
http://link.springer.com/article/10.1007/s10549-013-2800-y