Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James W. Cessac"'
Autor:
Klaus Nickisch, Shao-Qing Shi, Robert E. Garfield, Olga Amelkina, Narkunan Kesavaram, Baishakhi Das, Walter Elger, Reinhard Meister, James W. Cessac
Publikováno v:
Steroids. 78:255-267
A series of antiprogestins have been synthesized by partially fluorinating the steroid molecule in positions relevant for receptor binding. By introducing fluorine at the exo-methylene of the 17 spirofuran ring, we obtained partial agonists (mesoprog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ed82369c8adcac5cbaee43c0622bfd
https://doi.org/10.1016/j.steroids.2012.09.010
https://doi.org/10.1016/j.steroids.2012.09.010
Publikováno v:
Steroids. 73:171-183
The syntheses and antimitotic activity of several novel analogs of 2-methoxyestradiol are described. Structural modifications include ring-D homologation, aromatization of the six-membered ring-D to a chrysine type molecule, and introduction of unsat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b3f4e3d5019800d1bb38c1927cf072
https://doi.org/10.1016/j.steroids.2007.10.016
https://doi.org/10.1016/j.steroids.2007.10.016
Publikováno v:
Steroids. 73:158-170
The syntheses and antimitotic activity of several novel 18a-homo-analogs of 2-methoxyestradiol are described. Structural modifications of the parent 2-methoxy-18a-homoestradiol include introduction of unsaturation in the D-ring and methylation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a55389b8a16bc6b9349d9b3ee241e74
https://doi.org/10.1016/j.steroids.2007.11.003
https://doi.org/10.1016/j.steroids.2007.11.003
Autor:
Pemmaraju N. Rao, C. K. Acosta, James W. Cessac, James E. Burdett, P A Morrison, M. L. Bahr, Hyun K. Kim
Publikováno v:
Steroids. 65:395-400
A new practical synthesis of 17alpha-acetoxy-11beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione (CDB-2914) is described. The synthesis gives easily isolable solids at all steps and is amenable to large-scale process.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6bcd8bbb9311ef158e2cdb1af23990
https://doi.org/10.1016/s0039-128x(00)00100-8
https://doi.org/10.1016/s0039-128x(00)00100-8
Publikováno v:
Steroids. 64:205-212
The syntheses of N-desmethyl derivatives of CDB-2914 and the mono-N-desmethyl derivative of Mifepristone are described. We also describe the use of the mono-desmethyl derivatives as substrates for the synthesis of N-tritomethyl derivatives of CDB-291
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d4ec0f1ef4bfa124429b1f27f87135
https://doi.org/10.1016/s0039-128x(98)00086-5
https://doi.org/10.1016/s0039-128x(98)00086-5
Publikováno v:
Steroids. 59:621-627
Two preparative chemical methods for aromatization of 19-nor-delta 4-3-oxosteroids are described. The first method consists of an oxidative aromatization of 19-nor-delta 4-3-oxosteroids with iodine-ceric ammonium nitrate in methanol to give a mixture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13dfba5661ac03b34d5254bef48af5b0
https://doi.org/10.1016/0039-128x(94)90017-5
https://doi.org/10.1016/0039-128x(94)90017-5
Autor:
Hyun K. Kim, Rodolfo A. Martinez, M. L. Bahr, C. K. Acosta, Pemmaraju N. Rao, James W. Cessac, J. E. Jun. Burdett
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4233426b11c79aec70e808bcdb50ea9c
https://doi.org/10.1002/chin.199133264
https://doi.org/10.1002/chin.199133264
Publikováno v:
ChemInform. 23
The antiviral/antitumor marine alkaloid dercitin was used as a lead compound to design analogues with anti-HIV and tumor inhibitory activities. Deletion of structural features contributing to cytotoxicity led to analogues with lowered T-lymphocyte to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::191ab2d423d5d26453213c9777c0be19
https://doi.org/10.1002/chin.199252199
https://doi.org/10.1002/chin.199252199
Publikováno v:
Steroids. 57:216-221
Synthesis of the 11α-hemiglutaryl derivative of 5α-androstane-3α,17β-diol 17-glucuronide (androstanediol-17G) starting from androsta-4, 9(11)-diene-3,17-dione through a 10-step sequence and the preparation of its bovine serum albumin conjugate is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d48a3867be09ead75a6f9ceb7c5f679d
https://doi.org/10.1016/0039-128x(92)90105-i
https://doi.org/10.1016/0039-128x(92)90105-i
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 28:1201-1212
The synthesis of trans-4-n-butyl-2,3-3H-cyclohexanecarboxylic acid is described. The title compound was synthesized by catalytic tritiation of 4-n-butylcyclohex-2-enecarboxylic acid, which was obtained from a “double” Birch reduction of 4-n-butyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edfd3477b7a30ae714b702b4c986f901
https://doi.org/10.1002/jlcr.2580281013
https://doi.org/10.1002/jlcr.2580281013