Dynamics of macrophage trogocytosis of rituximab-coated B cells.

Autor: Theodore Pham, Patricia Mero, James W Booth

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e14498 (2011)

Macrophages can remove antigen from the surface of antibody-coated cells by a process termed trogocytosis. Using live cell microscopy and flow cytometry, we investigated the dynamics of trogocytosis by RAW264.7 macrophages of Ramos B cells opsonized

Externí odkaz: https://doaj.org/article/fa63e5d4a1b74aee94a247108c60c056

Differential Recruitment of Activating and Inhibitory FcγRII during Phagocytosis

Autor: Patricia Mero, Theodore Pham, Sujata Syam, Pierre Bruhns, James W. Booth, Courtney A.L. McIntosh

Publikováno v: Journal of Immunology
Journal of Immunology, 2010, 184 (6), pp.2966-2973. ⟨10.4049/jimmunol.0900016⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 184 (6), pp.2966-2973. ⟨10.4049/jimmunol.0900016⟩

International audience; Human myeloid cells express both activating and inhibitory receptors of the FcgammaRII family. FcgammaRIIA mediates processes associated with cell activation, including phagocytosis of IgG-opsonized particles, whereas coengage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9299ca9e5efa0c085ea4967f19d59c7
https://doi.org/10.4049/jimmunol.0900016

Contrasting requirements for ubiquitylation during Fc receptor-mediated endocytosis and phagocytosis

Autor: James W. Booth, Alan D. Schreiber, Moo-Kyung Kim, Sergio Grinstein, Andrzej Jankowski

Publikováno v: The EMBO Journal. 21:251-258

Fc receptors on leukocytes mediate internalization of antibody-containing complexes. Soluble immune complexes are taken up by endocytosis, while large antibody-opsonized particles are internalized by phagocytosis. We investigated the role of ubiquity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b233f24dc4e4fb50b71e1ce9317fc36
https://doi.org/10.1093/emboj/21.3.251

Restricted Accumulation of Phosphatidylinositol 3-Kinase Products in a Plasmalemmal Subdomain during Fcγ Receptor-Mediated Phagocytosis

Autor: Alan D. Schreiber, John Marshall, Tobias Meyer, Tamas Balla, Vuk Stambolic, James W. Booth, Tak W. Mak, Sergio Grinstein

Publikováno v: The Journal of Cell Biology

Phagocytosis is a highly localized and rapid event, requiring the generation of spatially and temporally restricted signals. Because phosphatidylinositol 3-kinase (PI3K) plays an important role in the innate immune response, we studied the generation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2db9ba160694a87d32ef550fae8e789
http://europepmc.org/articles/PMC2150726

Differences in endocytosis mediated by FcγRIIA and FcγRIIB2

Autor: Christine Y. Zhang, James W. Booth

Publikováno v: Molecular immunology. 49(1-2)

An important function of Fcγ receptors is the removal of IgG-containing immune complexes from the circulation. The activating receptor FcγRIIA and inhibitory receptor FcγRIIB2 are both expressed on human myeloid cells, and are both capable of medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3831026d7bb0ec76ff8fc6271a81b1e
https://pubmed.ncbi.nlm.nih.gov/21945020